Reversible Chemical Modification of Antibody Effector Function Mitigates Unwanted Systemic Immune Activation.

Autor: Moquist PN; ADC Chemistry, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United states., Zhang X; ADC Antibody Engineering, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Leiske CI; ADC Antibody Engineering, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Eng-Duncan NM; ADC Chemistry, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United states., Zeng W; ADC In Vivo Pharmacology, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Bindman NA; ADC Antibody Engineering, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Wo SW; ADC Antibody Engineering, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Wong A; ADC Translational Sciences, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Henderson CM; ADC Translational Sciences, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Crowder K; Non-Clinical Sciences, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Lyon R; ADC Antibody Engineering, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Doronina SO; ADC Chemistry, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United states., Senter PD; ADC Chemistry, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United states., Neff-LaFord HD; Non-Clinical Sciences, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Sussman D; ADC Antibody Engineering, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Gardai SJ; Immunology, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States., Levengood MR; ADC Antibody Engineering, Pfizer, Inc., 21823 30th Dr. SE, Bothell, Washington 98021, United States.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2024 Jun 19; Vol. 35 (6), pp. 855-866. Date of Electronic Publication: 2024 May 24.