Zobrazeno 1 - 10
of 588
pro vyhledávání: '"Eng H Lo"'
Autor:
Wi-Sun Ryu, Keun-Sik Hong, Sang-Wuk Jeong, Jung E Park, Beom Joon Kim, Joon-Tae Kim, Kyung Bok Lee, Tai Hwan Park, Sang-Soon Park, Jong-Moo Park, Kyusik Kang, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Moon-Ku Han, Man Seok Park, Kang-Ho Choi, Juneyoung Lee, Jeffrey L Saver, Eng H Lo, Hee-Joon Bae, Dong-Eog Kim
Publikováno v:
PLoS Medicine, Vol 19, Iss 2, p e1003910 (2022)
BackgroundPreclinical data suggest circadian variation in ischemic stroke progression, with more active cell death and infarct growth in rodent models with inactive phase (daytime) than active phase (nighttime) stroke onset. We aimed to examine the a
Externí odkaz:
https://doaj.org/article/64f407d75f9a476f87087476284482d8
Publikováno v:
Brain Circulation, Vol 5, Iss 3, Pp 145-149 (2019)
Stroke is one of the world's leading causes of mortality and morbidity. Greater understanding is required of the underlying relationships in ischemic brains in order to prevent stroke or to develop effective treatment. This review highlights new find
Externí odkaz:
https://doaj.org/article/ea36bf0fcc104f9eb3ba6a4ac284618d
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0218965 (2019)
Lipocalin-2 (LCN2) is a stress protein, and can be hyper-produced by many kinds of cells after exposure to injury or disease conditions. In this study, we asked whether LCN2 may play a protective role in cerebral endothelium. After focal cerebral isc
Externí odkaz:
https://doaj.org/article/28df49fd836a45c9a27beda9235465ae
Autor:
Hidehiro Ishikawa, Shintaro Kimura, Hajime Takase, Maximillian Borlongan, Norito Fukuda, Tomonori Hoshino, Gen Hamanaka, Ji Hyun Park, Akihiro Shindo, Kyu-Won Kim, Irwin H. Gelman, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract A-kinase anchoring protein 12 (AKAP12) is a key scaffolding protein that regulates cellular signaling by anchoring protein kinase A (PKA) and other signaling molecules. While recent studies suggest an important role for AKAP12 in the brain,
Externí odkaz:
https://doaj.org/article/783e15139445421ea37939fd2508fa49
Autor:
Tomonori Hoshino, Hajime Takase, Gen Hamanaka, Shintaro Kimura, Norito Fukuda, Emiri T. Mandeville, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The corpus callosum, a major white matter tract in the brain, undergoes age-related functional changes. To extend our investigation of age-related gene expression dynamics in the mouse corpus callosum, we compared RNA-seq data from 2 week-ol
Externí odkaz:
https://doaj.org/article/12e7aa4247b14b01a7b23aaf731dc7e4
Publikováno v:
Brain Circulation, Vol 1, Iss 1, Pp 104-113 (2015)
Beyond reperfusion therapies, there are still no widely effective therapies for ischemic stroke. Although much progress has been made to define the molecular pathways involved, targeted neuroprotective strategies have often failed in clinical trials.
Externí odkaz:
https://doaj.org/article/17f31b58e28b4ef2ac339a85430269ee
Autor:
Yinghua eJiang, Xiang eFan, Zhanyang eYu, Zhengbu eLiao, Xiao-Shu eWang, Klaus evan leyen, Xiaochuan eSun, Eng H Lo, Xiaoying eWang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
Risk of hemorrhagic transformation, incomplete reperfusion, neurotoxicity and a short treatment time window comprise major challenges for tissue plasminogen activator (tPA) thrombolytic stroke therapy. Improving tPA therapy has become one of the high
Externí odkaz:
https://doaj.org/article/69bc8f1c899c484e9a81e2a7d6706c8a
Autor:
Su Jing Chan, Chou Chai, Tze Wei Lim, Mie Yamamoto, Eng H Lo, Mitchell Kim Peng Lai, Peter Tsun Hon Wong
Publikováno v:
ASN Neuro, Vol 7 (2015)
Hydrogen sulfide (H 2 S) has been reported to exacerbate stroke outcome in experimental models. Cystathionine β-synthase (CBS) has been implicated as the predominant H 2 S-producing enzyme in central nervous system. When SH-SY5Y cells were transfect
Externí odkaz:
https://doaj.org/article/1c8d9a7ff6ff46f29f481136e4d4463b
Autor:
Seong-Ho Koh, Anna C Liang, Yoko Takahashi, Takakuni Maki, Akihiro Shindo, Noriko Osumi, Jing Zhao, Hong Lin, Julie C Holder, Tsu Tshen Chuang, John D McNeish, Ken Arai, Eng H Lo
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138724 (2015)
Adult mammalian brain can be plastic after injury and disease. Therefore, boosting endogenous repair mechanisms would be a useful therapeutic approach for neurological disorders. Isoxazole-9 (Isx-9) has been reported to enhance neurogenesis from neur
Externí odkaz:
https://doaj.org/article/b9dd175d20b44bf8ae6c1950c4205930
Autor:
Ji Hae Seo, Takakuni Maki, Mitsuyo Maeda, Nobukazu Miyamoto, Anna C Liang, Kazuhide Hayakawa, Loc-Duyen D Pham, Fumihiko Suwa, Akihiko Taguchi, Tomohiro Matsuyama, Masafumi Ihara, Kyu-Won Kim, Eng H Lo, Ken Arai
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103174 (2014)
Trophic coupling between cerebral endothelium and their neighboring cells is required for the development and maintenance of blood-brain barrier (BBB) function. Here we report that oligodendrocyte precursor cells (OPCs) secrete soluble factor TGF-β1
Externí odkaz:
https://doaj.org/article/59584deb9ae34d6998fd58c2ac00f6c6