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Akademický článek

Chemoenzymatic Synthesis of Asymmetrically Branched Human Milk Oligosaccharide Lacto-N-Hexaose

Autor: Kai-Eng Ooi, Xiu-Wen Zhang, Cheng-Yu Kuo, Ying-Jia Liu, Ching-Ching Yu

Publikováno v: Frontiers in Chemistry, Vol 10 (2022)

We herein reported the first chemoenzymatic synthesis of lacto-N-hexaose (LNH) by combining chemical carbohydrate synthesis with a selectively enzymatic glycosylation strategy. A tetrasaccharide core structure GlcNH2β1→3 (GlcNAcβ1→6) Galβ1→4

Externí odkaz: https://doaj.org/article/ad844c89a360424f88a27fff223555c5

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Akademický článek

First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background E7046 is a highly selective, small-molecule antagonist of the E-type prostanoid receptor 4 (EP4) for prostaglandin E2, an immunosuppressive mediator of the tumor immune microenvironment. This first-in-human phase 1 study assessed the safet

Externí odkaz: https://doaj.org/article/e224332c09c046d89e9e666fa3f6b4e3

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Managing Chronic otitis media with Effusion in Children with non-Syndromic Cleft Palate: Short-Term Ventilation Tubes Versus Surveillance

Autor: Grace Maina, Danielle Pollock, Craig Lockwood, Lachlan Cook, Eng Ooi

Publikováno v: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

Objective To compare the effectiveness of short-term ventilation tubes compared to surveillance on conductive hearing loss in children with non-syndromic orofacial clefting involving the muscular palate. Introduction Chronic otitis media with effusio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76681bc80864d9ee5981468d90f861d8
https://pubmed.ncbi.nlm.nih.gov/36600676

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Leaf transcriptomic signatures for somatic embryogenesis potential of Elaeis guineensis

Autor: Norashikin Sarpan, Chin-Ching Lim, Wei Chee Wong, Chin-Nee Choo, Choo-Kien Wong, Ishak Feshah, Azimi Nuraziyan, Foo-Hin Wong, Nabeel Ata, Siew-Eng Ooi, Meilina Ong-Abdullah

Publikováno v: Plant Cell Reports. 40:1141-1154

Potentially embryogenic oil palms can be identified through leaf transcriptomic signatures. Differential expression of genes involved in flowering time, and stress and light responses may associate with somatic embryogenesis potential. Clonal propaga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be39690134a18d03355dcdb2f1acc7b0
https://doi.org/10.1007/s00299-021-02698-1

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Small RNAs and Karma methylation in Elaeis guineensis mother palms are linked to high clonal mantling

Autor: Siew-Eng Ooi, Norashikin Sarpan, Elizaveta Taranenko, Ishak Feshah, Azimi Nuraziyan, Siti Habsah Roowi, Muhammad Nazmi Burhan, Nagappan Jayanthi, Abdul Rahman Siti Rahmah, Ooi-Kock Teh, Meilina Ong-Abdullah, Tatiana V. Tatarinova

Publikováno v: Plant molecular biology.

The mantled phenotype is an abnormal somaclonal variant arising from the oil palm cloning process and severe phenotypes lead to oil yield losses. Hypomethylation of the Karma retrotransposon within the B-type MADS-box EgDEF1 gene has been associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3323ff26639371b2b58753cf13ecc688
https://pubmed.ncbi.nlm.nih.gov/36609897

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