De novo Fatty Acid Biosynthesis Contributes Significantly to Establishment of a Bioenergetically Favorable Environment for Vaccinia Virus Infection

Autor: Paula Traktman, Matthew D. Greseth

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 10, Iss 3, p e1004021 (2014)

The poxvirus life cycle, although physically autonomous from the host nucleus, is nevertheless dependent upon cellular functions. A requirement for de novo fatty acid biosynthesis was implied by our previous demonstration that cerulenin, a fatty acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d318e674faec6085e5a0d1bddc964d

Metabolic effects of acute thiamine depletion are reversed by rapamycin in breast and leukemia cells

Autor: Mignon A. Keaton, Jeffrey A. Moscow, Sumitra Miriyala, Craig T. Jordan, Daret K. St. Clair, Christina M. Wiedl, Shuqian Liu

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85702 (2014)
PLoS ONE

Thiamine-dependent enzymes (TDEs) control metabolic pathways that are frequently altered in cancer and therefore present cancer-relevant targets. We have previously shown that the recombinant enzyme thiaminase cleaves and depletes intracellular thiam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9424ca9e4082e6c05747fcdf5599e5c
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24454921/?tool=EBI

Real-time measurements of the redox states of c-type cytochromes in electroactive biofilms: a confocal resonance Raman microscopy study

Autor: Damien J. Batstone, Bogdan C. Donose, Diego Millo, Bernardino Virdis

Publikováno v: PLoS ONE, 2014(9). Public Library of Science
PLoS ONE, Vol 9, Iss 2, p e89918 (2014)
Virdis, B, Millo, D, Donose, B C & Batstone, D J 2014, ' Real-time measurements of the redox states of c-type cytochromes in electroactive biofilms: a confocal resonance Raman microscopy study ', PLoS ONE, vol. 2014, no. 9, pp. e89918 . https://doi.org/10.1371/journal.pone.0089918
PLoS ONE

Confocal Resonance Raman Microscopy (CRRM) was used to probe variations of redox state of c-type cytochromes embedded in living mixed-culture electroactive biofilms exposed to different electrode polarizations, under potentiostatic and potentiodynami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c1e059388e2fc6e3e1372b5a665ccc
https://research.vu.nl/en/publications/7bfe27a0-a223-4cb6-b9cc-b1c4913669a0

Imaging mitochondrial flux in single cells with a FRET sensor for pyruvate

Autor: Karin Alegría, Felipe Baeza-Lehnert, Yasna Contreras-Baeza, Rocío Valdebenito, Sebastián Ceballo, Rodrigo Lerchundi, L. Felipe Barros, Alejandro San Martín

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85780 (2014)
PLoS ONE
Plos One
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Mitochondrial flux is currently accessible at low resolution. Here we introduce a genetically-encoded FRET sensor for pyruvate, and methods for quantitative measurement of pyruvate transport, pyruvate production and mitochondrial pyruvate consumption

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384ebf56cefc28b49690a4b00a8d743a
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465702/?tool=EBI

Transcriptomic analysis of carboxylic acid challenge in Escherichia coli: beyond membrane damage

Autor: Laura R. Jarboe, Ping Liu, Julie A. Dickerson, Erin E. Boggess, Yao Fu, Liam A. Royce, Jacqueline V. Shanks

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e89580 (2014)

Carboxylic acids are an attractive biorenewable chemical. Enormous progress has been made in engineering microbes for production of these compounds though titers remain lower than desired. Here we used transcriptome analysis of Escherichia coli durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc92cc71a6150b0926e57e6cd312f43
https://pubmed.ncbi.nlm.nih.gov/24586888