Transdermal Delivery of a Hydrogen Sulphide Donor, ADT-OH Using Aqueous Gel Formulations for the Treatment of Impaired Vascular Function:an Ex Vivo Study

Autor: Mandeep Marwah, Hala Shokr, Lissette Sanchez-Aranguren, Shakil Ahmad, Raj Badhan, Keqing Wang

Publikováno v: Marwah, M K, Shokr, H, Sanchez-Aranguren, L, Badhan, R K S, Wang, K & Ahmad, S 2022, ' Transdermal Delivery of a Hydrogen Sulphide Donor, ADT-OH Using Aqueous Gel Formulations for the Treatment of Impaired Vascular Function : an Ex Vivo Study ', Pharmaceutical Research, vol. 39, no. 2, pp. 341-352 . https://doi.org/10.1007/s11095-021-03164-z

Purpose Hydrogen sulphide (H2S) is an important signalling molecule involved in the regulation of several physiological and pathophysiological processes. The objective of this study was to investigate the feasibility of transdermal delivery of ADT-OH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18579ddcfb98e9269edf2d5f93395c27
https://doi.org/10.1007/s11095-021-03164-z

The immunometabolic role of indoleamine 2,3-dioxygenase in atherosclerotic cardiovascular disease: immune homeostatic mechanisms in the artery wall

Autor: Daniel F. J. Ketelhuth

Publikováno v: Ketelhuth, D F J 2019, ' The immunometabolic role of indoleamine 2 3-dioxygenase in atherosclerotic cardiovascular disease : immune homeostatic mechanisms in the artery wall ', Cardiovascular Research, vol. 115, no. 9, pp. 1408-1415 . https://doi.org/10.1093/cvr/cvz067

Coronary heart disease and stroke, the two most common cardiovascular diseases worldwide, are triggered by complications of atherosclerosis. Atherosclerotic plaques are initiated by a maladaptive immune response triggered by accumulation of lipids in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754e76d35f41858a7875f9f81b073d6d
https://doi.org/10.1093/cvr/cvz067

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

Autor: Maren Lindner, Béatrice Pignolet, David Brassat, Petra Hundehege, Maria Eveslage, Melanie Eschborn, Johanna Breuer, Luisa Klotz, Karin Loser, Andreas Schulte-Mecklenbeck, Sven G. Meuth, Judith Austermann, Catharina C. Gross, Nicole Freise, Karin B. Busch, Nicholas Schwab, Giulia Nebel, Tilman Schneider-Hohendorf, Timothy J. Turner, Vilmos Posevitz, Heinz Wiendl, Marie Liebmann, Amit Bar-Or, Martin Herold, Shirin Glander, Belén Torres Garrido, Johannes Roth, Claudia Janoschka, Timo Wirth, Graham R. Campbell, Don J. Mahad, Monika Stoll

Publikováno v: Klotz, L, Eschborn, M, Lindner, M, Liebmann, M, Herold, M, Janoschka, C, Torres Garrido, B, Schulte-Mecklenbeck, A, Gross, C C, Breuer, J, Hundehege, P, Posevitz, V, Pignolet, B, Nebel, G, Glander, S, Freise, N, Austermann, J, Wirth, T, Campbell, G R, Schneider-Hohendorf, T, Eveslage, M, Brassat, D, Schwab, N, Loser, K, Roth, J, Busch, K B, Stoll, M, Mahad, D J, Meuth, S G, Turner, T, Bar-Or, A & Wiendl, H 2019, ' Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects ', Science Translational Medicine, vol. 11, no. 490, eaao5563 . https://doi.org/10.1126/scitranslmed.aao5563
Science Translational Medicine, 11(490):5563. American Association for the Advancement of Science
Science Translational Medicine
Science Translational Medicine, 2019, 11 (490), ⟨10.1126/scitranslmed.aao5563⟩

International audience; Interference with immune cell proliferation represents a successful treatment strategy in T cell-mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis (MS). One prominent example is pharmacological i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c6a6928d973af7c45bf548e65e0113
https://hdl.handle.net/20.500.11820/c76c0dcd-4614-4fdc-92e3-04332843a83f

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Autor: Maximilian Kleinert, Josefine Reber, Tim Gruber, Emmani B.M. Nascimento, Timo D. Müller, Stephan Sachs, Patrick Schrauwen, Martin Jastroch, Susanna M. Hofmann, Brian Finan, Vasilis Ntziachristos, Christoffer Clemmensen, Matthias H. Tschöp, Gerald Grandl, Annette Feuchtinger, Michael A. Cowley, Carmelo Quarta, Stephanie E. Simonds, Sigrid Jall, Angelos Karlas, Susanne Keipert, Daniela Loher, Eva Sanchez-Quant, Katrin Fischer

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Clemmensen, C, Jall, S, Kleinert, M, Quarta, C, Gruber, T, Reber, J, Sachs, S, Fischer, K, Feuchtinger, A, Karlas, A, Simonds, S E, Grandl, G, Loher, D, Sanchez-Quant, E, Keipert, S, Jastroch, M, Hofmann, S M, Nascimento, E B M, Schrauwen, P, Ntziachristos, V, Cowley, M A, Finan, B, Müller, T D & Tschöp, M H 2018, ' Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes ', Nature Communications, vol. 9, 4304 . https://doi.org/10.1038/s41467-018-06769-y
Nature Communications, 9:4304. Nature Publishing Group
Nat. Commun. 9:4304 (2018)

Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued as a viable anti-obesity strategy. Here, we report that pharmacological activation of the cold receptor transient re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101ff71e3282c5fe6bf40d3b607f7b73
https://mediatum.ub.tum.de/doc/1510435/document.pdf

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain

Autor: Karen Saritas-Brauers, Gert Schaart, Jacob J. Briedé, Jos C. S. Kleinjans, Jian Jiang, Anke Van Summeren, Theo M.C.M. de Kok, Danyel Jennen

Publikováno v: Toxicology Letters, 234(2), 139-150. Elsevier Ireland Ltd

Acetaminophen (APAP) overdosage results in hepatotoxicity, but the underlying molecular mechanisms are still not completely understood. In the current study, we focused on mitochondrial-specific oxidative liver injury induced by APAP exposure. Owning

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0188ba8d1047d26ca6fa0b7bc9eea683
https://doi.org/10.1016/j.toxlet.2015.02.012