Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eneida Pardo"'
Autor:
Andrew R Conery, Richard C Centore, Adrianne Neiss, Patricia J Keller, Shivangi Joshi, Kerry L Spillane, Peter Sandy, Charlie Hatton, Eneida Pardo, Laura Zawadzke, Archana Bommi-Reddy, Karen E Gascoigne, Barbara M Bryant, Jennifer A Mertz, Robert J Sims III
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/0ea297e6ae5f467d80133d7259ae7025
Autor:
Andrew R Conery, Richard C Centore, Adrianne Neiss, Patricia J Keller, Shivangi Joshi, Kerry L Spillane, Peter Sandy, Charlie Hatton, Eneida Pardo, Laura Zawadzke, Archana Bommi-Reddy, Karen E Gascoigne, Barbara M Bryant, Jennifer A Mertz, Robert J Sims III
Publikováno v:
eLife, Vol 5 (2016)
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective attenuation of gene expression. Here, we demonstrate that CBP/EP300 bromodomain inhibition pref
Externí odkaz:
https://doaj.org/article/d331aee4f7f14c128cc3a9998e1d79c4
Autor:
Maureen Caligiuri, Grace L. Williams, Jennifer Castro, Linda Battalagine, Erik Wilker, Lili Yao, Shawn Schiller, Angela Toms, Ping Li, Eneida Pardo, Bradford Graves, Joey Azofeifa, Agustin Chicas, Torsten Herbertz, Maria Lai, Joel Basken, Kenneth W. Wood, Qunli Xu, Sylvie M. Guichard
Publikováno v:
Targeted Oncology. 18:269-285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b83a4b5ffa700d6591f630c62f30ad00
https://doi.org/10.1007/s11523-023-00949-7
https://doi.org/10.1007/s11523-023-00949-7
Autor:
G. Joseph Franklin, David R. Lancia, Christopher S. Kollmann, Kelly A. McCarthy, Eneida Pardo, Jonathan C. O’Connell, Martin Olbrot
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(5)
DNA-encoded library (DEL) technology has become a prominent screening platform in drug discovery owing to the capacity to screen billions or trillions of compounds in a single experiment. Although numerous successes with DEL technology have been repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca5d3eb46e4e5dae3c2de3deba4fe6f
https://pubmed.ncbi.nlm.nih.gov/32107961
https://pubmed.ncbi.nlm.nih.gov/32107961
Autor:
Shumei Wang, Peter Sandy, Christopher G. Nasveschuk, Terry Crawford, Brian K. Albrecht, Andrea G. Cochran, Steffan Vartanian, Hon-Ren Huang, Vickie Tsui, David Stokoe, Steve Bellon, Yong Tang, E. Megan Flynn, Jian Wang, James R. Kiefer, Jeremy Murray, F. Anthony Romero, Laura Zawadzke, Michael C. Hewitt, Martin Duplessis, Alexander M. Taylor, Eneida Pardo, Alexandre Côté, Steven Magnuson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3534-3541
Bromodomain-containing protein 9 (BRD9), an epigenetic "reader" of acetylated lysines on post-translationally modified histone proteins, is upregulated in multiple cancer cell lines. To assess the functional role of BRD9 in cancer cell lines, we iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8525424a9e42e8118660fc4dcf374c9
https://doi.org/10.1016/j.bmcl.2017.05.063
https://doi.org/10.1016/j.bmcl.2017.05.063
Autor:
Arianne Neiss, Martin Duplessis, Hariharan Jayaram, Shumei Wang, F. Anthony Romero, Christopher G. Nasveschuk, Daniel J. Burdick, James E. Audia, Terry Crawford, Steve Bellon, Hon-Ren Huang, Zhaowu Xu, Yongyun Wang, Ying Jiang, Michael C. Hewitt, Jeremy Murray, Andrea G. Cochran, Peter Sandy, Yong Tang, Brian K. Albrecht, E. Megan Flynn, James R. Kiefer, Archana Bommi-Reddy, Jian Wang, Laura Zawadzke, Shivangi Joshi, Vickie Tsui, Xiaoqin Zhu, Alexander M. Taylor, Robert J. Sims, Eneida Pardo, Alexandre Côté, Steven Magnuson, Richard T. Cummings
Publikováno v:
ACS Medicinal Chemistry Letters. 8:737-741
The biological function of bromodomains, epigenetic readers of acetylated lysine residues, remains largely unknown. Herein we report our efforts to discover a potent and selective inhibitor of the bromodomain of cat eye syndrome chromosome region can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34adc0dbe643caf51d004a4e038645f9
https://doi.org/10.1021/acsmedchemlett.7b00132
https://doi.org/10.1021/acsmedchemlett.7b00132
Autor:
Robert M. Campbell, Yves Leblanc, James E. Audia, Jennifer A. Mertz, Brian K. Albrecht, Michael R. Cooper, Jeffrey G. Supko, Emmanuel Normant, Florence Poy, Christopher G. Nasveschuk, Richard T. Cummings, Michael C. Hewitt, Adrianne Neiss, Victor S. Gehling, Louise Bergeron, Jean-Christophe Harmange, Peter Sandy, Michael O'Meara, Alexander M. Taylor, Robert J. Sims, Nico Cantone, Eneida Pardo, Alexandre Côté, Shivangi Joshi, Hariharan Jayaram, Rishi G. Vaswani, Steve Bellon
Publikováno v:
Journal of Medicinal Chemistry. 59:1330-1339
In recent years, inhibition of the interaction between the bromodomain and extra-terminal domain (BET) family of chromatin adaptors and acetyl-lysine residues on chromatin has emerged as a promising approach to regulate the expression of important di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9c61f62ece4a112dbbc1ba0de53887
https://doi.org/10.1021/acs.jmedchem.5b01882
https://doi.org/10.1021/acs.jmedchem.5b01882
Autor:
Linda Battalagine, Shawn Schiller, Angela V. Toms, Ping Li, Lili Yao, Maureen Caligiuri, Grace L. Williams, Jennifer Castro, Sylvie Guichard, Kristina R Muskiewicz, Erik Wilker, Eneida Pardo, Kenneth W. Wood, Bradford Graves
Publikováno v:
Cancer Research. 80:3079-3079
Triple negative breast cancer (TNBC) remains a high unmet medical need, commonly treated with chemotherapies. Biomarker-driven treatment strategies have led to the recent approvals of both PARP inhibitors and an immune checkpoint inhibitor for a subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3adb57729a88fc4485b22526b7e9c1
https://doi.org/10.1158/1538-7445.am2020-3079
https://doi.org/10.1158/1538-7445.am2020-3079
Autor:
Shumei Wang, Vickie Tsui, Terry D. Crawford, James E. Audia, Daniel J. Burdick, Maureen H. Beresini, Alexandre Côté, Richard Cummings, Martin Duplessis, E. Megan Flynn, Michael C. Hewitt, Hon-Ren Huang, Hariharan Jayaram, Ying Jiang, Shivangi Joshi, Jeremy Murray, Christopher G. Nasveschuk, Eneida Pardo, Florence Poy, F. Anthony Romero, Yong Tang, Alexander M. Taylor, Jian Wang, Zhaowu Xu, Laura E. Zawadzke, Xiaoyu Zhu, Brian K. Albrecht, Steven R. Magnuson, Steve Bellon, Andrea G. Cochran
Publikováno v:
Journal of medicinal chemistry. 61(20)
The biological functions of the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1(1,2)) remain unknown, although TAF1 has been identified as a potential target for oncology research. Here, we describe the discovery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608b00b850e4a2287fb36f7aa68c18f2
https://pubmed.ncbi.nlm.nih.gov/30289257
https://pubmed.ncbi.nlm.nih.gov/30289257
Autor:
Jennifer A. Mertz, Michael C. Hewitt, Hari Jayaram, Yves Leblanc, Richard T. Cummings, Robert J. Sims, Eneida Pardo, Alexandre Côté, Alex M. Taylor, Christopher G. Nasveschuk, Jeremy W. Setser, Brian K. Albrecht, Steve Bellon, Jean-Christophe Harmange, James E. Audia, Jose M. Lora, Florence Poy, Shivangi Joshi, Rishi G. Vaswani, Yong Tang, Peter Sandy, Victor S. Gehling, Adrianne Neiss
Publikováno v:
ACS Medicinal Chemistry Letters. 7:145-150
Inhibition of the bromodomains of the BET family, of which BRD4 is a member, has been shown to decrease myc and interleukin (IL) 6 in vivo, markers that are of therapeutic relevance to cancer and inflammatory disease, respectively. Herein we report s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d678aa93a9be92a8c569f477f58989
https://doi.org/10.1021/ml500411h
https://doi.org/10.1021/ml500411h