Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Endri, Karaj"'
Autor:
Riddhidev, Banerjee, Endri, Karaj, Sabitri, Lamichhane, Kotsull, Lauren, N., Nishanth, Kuganesan, Dragan, Isailovic, Mary Kay H, Pflum, James, Slama, William, Taylor, L. M. Viranga, Tillekeratne
Publikováno v:
In European Journal of Medicinal Chemistry 15 December 2022 244
Autor:
Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Radhika A. Koranne, Joseph R. Knoff, Antonisamy William James, Yu Fu, Lauren N. Kotsull, Mary Kay Pflum, Zahoor Shah, William R. Taylor, L. M. Viranga Tillekeratne
Publikováno v:
Journal of Medicinal Chemistry. 65:14764-14791
HDAC inhibitors are an attractive class of cytotoxic agents for the design of hybrid molecules. Several HDAC hybrids have emerged over the years, but none combines HDAC inhibition with ferroptosis, a combination which is being extensively studied bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4664fff8226159824204e3ba7728ff
https://doi.org/10.1021/acs.jmedchem.2c01276
https://doi.org/10.1021/acs.jmedchem.2c01276
Autor:
Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Lalith Perera, William Taylor, L. M. Viranga Tillekeratne
Publikováno v:
Journal of Medicinal Chemistry. 65:11788-11817
Once considered potential liabilities, the modern era witnesses a renaissance of interest in covalent inhibitors in drug discovery. The available toolbox of electrophilic warheads is limited by constraints on tuning reactivity and selectivity. Follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc21fb990e1b98b1e826d50ea07298c
https://doi.org/10.1021/acs.jmedchem.2c00909
https://doi.org/10.1021/acs.jmedchem.2c00909
Autor:
Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Lalith Perera, William Taylor, L. M. Viranga Tillekeratne
Covalent inhibitors have historically been considered potential liabilities in medicinal chemistry. The modern era witnesses a renaissance of interest in irreversible binders. The available toolbox of electrophilic warheads is limited with constraint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::119551cc470b4369e3445611d1ac4f33
https://doi.org/10.26434/chemrxiv-2022-h9t07
https://doi.org/10.26434/chemrxiv-2022-h9t07
Publikováno v:
Bioorganicmedicinal chemistry. 62
Small molecules remain an important category of therapeutic agents. Their binding to different proteins can lead to both desired and undesired biological effects. Identification of the proteins that a drug binds to has become an important step in dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67346b4e3297cc88deb7d26d91cabcdc
https://pubmed.ncbi.nlm.nih.gov/35358862
https://pubmed.ncbi.nlm.nih.gov/35358862
Autor:
Ronald V. Emmons, Endri Karaj, Erasmus Cudjoe, David S. Bell, L.M. Viranga Tillekeratne, Emanuela Gionfriddo
Publikováno v:
Journal of Chromatography A. 1685:463636
Effective quantitative analysis of BMAA (β-N-methylamino-L-alanine) and its isomers without the need for derivatization has always been an analytical challenge due to their poor retention and separation on various liquid chromatography stationary ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26eeb11dd5e57ffdf2992acd7bc23831
https://doi.org/10.1016/j.chroma.2022.463636
https://doi.org/10.1016/j.chroma.2022.463636
Autor:
Abdulateef Alqahtani, Ayad A. Al-Hamashi, Matthew Dunworth, Joseph R. Knoff, Robert A. Casero, Mary Kay H. Pflum, Lalith Perera, Endri Karaj, L. M. Viranga Tillekeratne, Radhika Koranne, Maisha S. Rashid, Samkeliso Dlamini, William R. Taylor
Publikováno v:
Bioorg Chem
Despite the advances in treatment strategies, cancer is still the second leading cause of death in the USA. A majority of the currently used cancer drugs have limitations in their clinical use due to poor selectivity, toxic side effects and multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fef0848d1028eade72991abcff704bb
https://pubmed.ncbi.nlm.nih.gov/34509798
https://pubmed.ncbi.nlm.nih.gov/34509798
Autor:
Endri, Karaj, Samkeliso, Dlamini, Radhika, Koranne, Shaimaa H, Sindi, Lalith, Perera, William R, Taylor, L M, Viranga Tillekeratne
Publikováno v:
Bioorganic Chemistry. 122:105700
We recently reported a new class of imidazole-based chalcones as potential antimitotic agents. In view of their promising cytotoxic activity, a comprehensive structure-activity relationship (SAR) of these compounds was undertaken focusing on four maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970fd5f8946371e5c16bbc321dca08ad
https://doi.org/10.1016/j.bioorg.2022.105700
https://doi.org/10.1016/j.bioorg.2022.105700
Autor:
Daniyah A. Almarghalani, Endri Karaj, Muhammed Alzweiri, Amsha S. Alsegiani, Yahia Tabaza, Zahoor A. Shah, L. M. Viranga Tillekeratne
Publikováno v:
Bioorg Med Chem Lett
Alzheimer’s disease (AD) is a neurodegenerative disorder, projected to be the second leading cause of mortality by 2040. AD is characterized by a progressive impairment of memory leading to dementia and loss of ability to carry out daily functions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81be21d0da36e09353ea6fc582c1dc63
https://doi.org/10.1016/j.bmcl.2021.128205
https://doi.org/10.1016/j.bmcl.2021.128205