Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Endralazine"'
Autor:
Ruben Vardanyan
This chapter describes methods of synthesis, pharmacological properties and the use of derivatives of piperidine-based fused biheterocycles represented on the pharmaceutical market as thienopyridine-derivatives such as ticlopidine, clopidogrel, and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c16e9f1cce1c8a8071542b3415ae39a
https://doi.org/10.1016/b978-0-12-805157-3.00008-9
https://doi.org/10.1016/b978-0-12-805157-3.00008-9
Publikováno v:
DMW - Deutsche Medizinische Wochenschrift. 106:1176-1181
In 16 fo 20 patients with treatment-resistant hypertension endralazine, combined with beta-receptor blockers and diuretics, significantly lowered mean arterial blood pressure from 198/112 mmHg to 148/88 mmHg. The initial dose of endralazine was 2.5 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15ad6cdd370ccb581a4ac8e883cd134f
https://doi.org/10.1055/s-2008-1070477
https://doi.org/10.1055/s-2008-1070477
Autor:
Ingrid Hunz, Wolfgang Hanefeld
Publikováno v:
Archiv der Pharmazie. 325:621-622
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68637ffdd6cb532333949ad4e7ab52bb
https://doi.org/10.1002/ardp.19923250919
https://doi.org/10.1002/ardp.19923250919
Publikováno v:
Journal of Cardiovascular Pharmacology. 4:562-566
In a randomized cross-over trial in 23 patients with essential hypertension, a new peripheral vasodilator, endralazine, in a dose of 10-20 mg t.i.d. was compared with dihydralazine in a dose of 25-50 mg t.i.d. All patients also received pindolol (a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2adb80e081fcd52ca760fd8542f1c189
https://doi.org/10.1097/00005344-198207000-00006
https://doi.org/10.1097/00005344-198207000-00006
Publikováno v:
European Journal of Clinical Pharmacology. 27:159-163
The influence of renal impairment on the pharmacokinetics of endralazine was studied in 12 patients; 4 patients on regular haemodialysis therapy (creatinine clearance less than 5 ml/min) and 8 patients with varying degrees of renal impairment (creati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e5b1c4692d9fa9c2609ffcac1e6da5
https://doi.org/10.1007/bf00544039
https://doi.org/10.1007/bf00544039
Publikováno v:
European Journal of Clinical Pharmacology. 23:523-527
Five and 10 mg single oral doses of a new vasodilator antihypertensive, endralazine (E) were given on separate occasions to 17 normal male volunteers (8 slow, 7 heterozygous fast and 2 homozygous fast acetylators). The homozygous fast acetylators wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b6d347d4efabb3a95432983a493a2f
https://doi.org/10.1007/bf00637500
https://doi.org/10.1007/bf00637500
Publikováno v:
European Journal of Pharmacology. 95:151-159
The hemodynamic effects of the vasodilators hydralazine, dihydralazine and endralazine were studied in conscious, unrestrained spontaneously hypertensive rats (SHR) equipped for chronic hemodynamic measurements. The arteriolar vasodilators hydralazin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2132365affb208449e3b35f3250e5c9c
https://doi.org/10.1016/0014-2999(83)90629-5
https://doi.org/10.1016/0014-2999(83)90629-5
Publikováno v:
British Journal of Clinical Pharmacology. 16:39-44
The effects of endralazine, administered intravenously, on blood pressure, heart rate, forearm blood flow, plasma renin activity, aldosterone, adrenaline and noradrenaline were studied in five patients with essential hypertension. Endralazine reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcbe51ccdeb72dbc1557b71f89bf69f
https://doi.org/10.1111/j.1365-2125.1983.tb02141.x
https://doi.org/10.1111/j.1365-2125.1983.tb02141.x
Publikováno v:
European Journal of Clinical Pharmacology. 30:553-557
Endralazine, a novel vasodilator related to hydralazine, exhibits a longer half-life and is only minimally influenced by acetylator status. The antihypertensive action of once daily endralazine has been studied in 17 patients previously controlled wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f67e9665690a3d16d51ef084ecfdaa
https://doi.org/10.1007/bf00542414
https://doi.org/10.1007/bf00542414
Publikováno v:
British Journal of Clinical Pharmacology. 16:27-32
The direct-acting vasodilator, endralazine, in combination with a beta-adrenoceptor blocker significantly reduced the blood pressures of normotensive volunteers and of patients with essential hypertension. The mean terminal elimination half-life for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1f1824f73c1ed6040d2756e891799b
https://doi.org/10.1111/j.1365-2125.1983.tb02139.x
https://doi.org/10.1111/j.1365-2125.1983.tb02139.x