Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Endothelium, Vascular/cytology/drug effects"'
Autor:
Camila B. Almeida, Jung Eun Jang, Nicola Conran, Christoph Scheiermann, Colette Prophete, Fernando Ferreira Costa, Paul S. Frenette
Publikováno v:
Blood, Vol. 120, No 14 (2012) pp. 2879-2888
Inhibition of leukocyte adhesion to the vascular endothelium represents a novel and important approach for decreasing sickle cell disease (SCD) vaso-occlusion. Using a humanized SCD–mouse-model of tumor necrosis factor-α–induced acute vaso-occlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83c94f5bdde182f2aafd109e4471a9b
https://doi.org/10.1182/blood-2012-02-409524
https://doi.org/10.1182/blood-2012-02-409524
Autor:
Pal Pacher, Lucas Liaudet, György Haskó, Grzegorz Godlewski, Mohanraj Rajesh, Sandor Batkai, Partha Mukhopadhyay
Publikováno v:
Biochemical and Biophysical Research Communications, vol. 350, no. 2, pp. 352-7
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which plays an important role in regulating cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP are being considered as treatment for cancer both in monotherapy as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e8b6acb3664c82f4d6e0b9bc15d153
https://doi.org/10.1016/j.bbrc.2006.09.049
https://doi.org/10.1016/j.bbrc.2006.09.049
Autor:
Theodore Fotsis, Werner Lutz, Elissavet Hatzi, Stephen Breit, Lothar Schweigerer, Manfred Schwab, Jochen Rössler
Publikováno v:
European Journal of Biochemistry. 263:757-764
Recent evidence indicates that the genetic alterations of the multistage process of malignant transformation appear to activate tumor neovascularization by altering the balance between stimulators and inhibitors of angiogenesis. In the present study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ece1b8d685b04d3dc5764b92308b5d4
https://doi.org/10.1046/j.1432-1327.1999.00575.x
https://doi.org/10.1046/j.1432-1327.1999.00575.x
Autor:
Susanne Alban, Ralf Ludwig, Wolf-Henning Boehncke, Roland Kaufmann, Juliane Fritzsche, Michael P. Schön, Gertie J. Oostingh, Heinfried H. Radeke, Josef Pfeilschifter, Gerd Bendas
Publikováno v:
Journal of Investigative Dermatology, Vol. 129, No 5 (2009) pp. 1192-1202
Leukocyte extravasation is initiated by an interaction of selectin adhesion molecules and appropriate carbohydrate ligands. Targeting those interactions seems a promising approach to treat chronic inflammation. We developed a beta-1, 3-glucan sulfate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4c2ff76ae24f935c8cb74cf0b45aad
https://pubmed.ncbi.nlm.nih.gov/19052560
https://pubmed.ncbi.nlm.nih.gov/19052560
Publikováno v:
The Journal of Cell Biology
The Journal of Cell Biology, Vol. 111, No 2 (1990) pp. 743-755
The Journal of Cell Biology, Vol. 111, No 2 (1990) pp. 743-755
Tightly controlled proteolytic degradation of the extracellular matrix by invading microvascular endothelial cells is believed to be a necessary component of the angiogenic process. We have previously demonstrated the induction of plasminogen activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda180667cdb7f8481da7f684e851a0a
https://doi.org/10.1083/jcb.111.2.743
https://doi.org/10.1083/jcb.111.2.743
Autor:
Susanne Alban, Gabriele Schumacher, Simone A. Rubant, Juliane Fritzsche, Ralf Ludwig, Gerd Bendas, Wolf-Henning Boehncke
Publikováno v:
Biochemical Pharmacology, Vol. 72, No 4 (2006) pp. 474-485
Selectin-mediated leukocyte rolling along the endothelium is of key importance for maintaining the cellular immune response. The anti-inflammatory activities of heparin have partly been related to inhibition of P-selectin binding. Heparin, however, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d35682e9a0b5985bfb6218c35344ff
https://pubmed.ncbi.nlm.nih.gov/16780802
https://pubmed.ncbi.nlm.nih.gov/16780802
Autor:
André Haeberli, Katja Matozan, Thomas Laumonier, Paul Mohacsi, Alexander J. Walpen, Elena Korchagina, Robert Rieben, Nicolai V. Bovin
Publikováno v:
Xenotransplantation, Vol. 11, No 3 (2004) pp. 262-8
BACKGROUND: Activation of endothelial cells (EC) in xenotransplantation is mostly induced through binding of antibodies (Ab) and activation of the complement system. Activated EC lose their heparan sulfate proteoglycan (HSPG) layer and exhibit a proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b7f9a24fa18a6da223d845311b947b
https://archive-ouverte.unige.ch/unige:40455
https://archive-ouverte.unige.ch/unige:40455
The adherens junction is a multiprotein complex consisting of the transmembrane vascular endothelial cadherin (VEC) and cytoplasmic catenins (p120, beta-catenin, plakoglobin, alpha-catenin) responsible for the maintenance of endothelial barrier funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10561::498b8fbdffe070962151a3c0ffa76750
http://olympias.lib.uoi.gr/jspui/handle/123456789/18955
http://olympias.lib.uoi.gr/jspui/handle/123456789/18955
Autor:
Christine F. Maurus, Thomas Laumonier, Jorg Dieter Seebach, Bernard Vanhove, Paul Mohacsi, Nicolai V. Bovin, Elena Korchagina, Robert Rieben, Alexander J. Walpen, Katja Matozan
Publikováno v:
Transplantation, Vol. 76, No 5 (2003) pp. 838-43
Background. The innate immune system, including complement and natural killer (NK) cells, plays a critical role in activation and damage of endothelial cells (ECs) during xenograft rejection. The semisynthetic proteoglycan analog dextran sulfate (DXS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096d9773ce6c896cce18ae16efe4efb0
https://archive-ouverte.unige.ch/unige:40448
https://archive-ouverte.unige.ch/unige:40448
Autor:
Roberto Montesano, Theodore Fotsis, Youming Zhang, Peter P. Nawroth, Michael S. Pepper, Herman Adlercreutz, Lothar Schweigerer
Publikováno v:
Nature. 368:237-239
The formation of new blood vessels (angiogenesis) is critical for the growth of tumours and is a dominant feature in various angiogenic diseases such as diabetic retinopathy, arthritis, haemangiomas and psoriasis. Recognition of the potential therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556a0a02a416b09828de805e52ae96e1
https://doi.org/10.1038/368237a0
https://doi.org/10.1038/368237a0