Zobrazeno 1 - 10
of 1 485
pro vyhledávání: '"Endothelial to Mesenchymal Transition"'
Autor:
Reyhaneh Niayesh-Mehr, Mojtaba Kalantar, Giulio Bontempi, Claudia Montaldo, Saeedeh Ebrahimi, Abdolamir Allameh, Ghader Babaei, Faezeh Seif, Raffaele Strippoli
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Despite the tremendous advancements in the knowledge of the pathophysiology and clinical aspects of SARS-CoV-2 infection, still many issues remain unanswered, especially in the long-term effects. Mounting evidence suggests that pulmonary fib
Externí odkaz:
https://doaj.org/article/eb2fbefc3d8f4831a55341f22cd70047
Autor:
Guizhen Zhao, Yang Zhao, Wenying Liang, Haocheng Lu, Hongyu Liu, Yongjie Deng, Tianqing Zhu, Yanhong Guo, Lin Chang, Minerva T. Garcia-Barrio, Y. Eugene Chen, Jifeng Zhang
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract Background Atherosclerotic cardiovascular diseases remain the leading cause of mortality in diabetic patients, with endothelial cell (EC) dysfunction serving as the initiating step of atherosclerosis, which is exacerbated in diabetes. Krüpp
Externí odkaz:
https://doaj.org/article/5ceec1f643e142d68958d73f93f18010
Autor:
Ruhao Wu, Ge Zhang, Mingzhou Guo, Yue Li, Lu Qin, Tianci Jiang, Pengfei Li, Yu Wang, Ke Wang, Yize Liu, Zhiqiu He, Zhe Cheng
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Pulmonary arterial hypertension (PAH) is a progressive and rapidly fatal disease with an intricate etiology. Identifying biomarkers for early PAH lesions based on the exploration of subtle biological processes is significant for timely diagn
Externí odkaz:
https://doaj.org/article/9a39d49464f742fa95c4fea841bd7cff
Publikováno v:
Cerebrovascular Diseases Extra, Vol 14, Iss 1, Pp 165-176 (2024)
Introduction: Our research aimed to investigate the potential role and mechanism of lysyl oxidase (LOX)-like 2 (LOXL2) in atherosclerosis (AS) by using the human umbilical vein endothelial cells (HUVECs) stimulated by oxidized low-density lipoprotein
Externí odkaz:
https://doaj.org/article/ddf64441ac0b4a83b1b67dfe8c4c8874
Autor:
Chenting Zhang, Yue Xing, Xuefen Wu, Qian Jiang, Xiaoyun Luo, Wei He, Shiyun Liu, Wenju Lu, Jian Wang
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background As a subtype of pulmonary hypertension (PH), pulmonary veno-occlusive disease (PVOD) is devastating and life-threatening disease without effective therapy. Hydrogen has been reported to exhibits antioxidant and anti-inflammatory e
Externí odkaz:
https://doaj.org/article/bcb4ec9e23ed4b9090c87538a4569548
Autor:
Xin Yu, Jiabing Huang, Xu Liu, Juan Li, Miao Yu, Minghui Li, Yuliang Xie, Ye Li, Junyu Qiu, Zhou Xu, Tiantian Zhu, Weifang Zhang
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Hypoxic pulmonary hypertension (HPH) is a challenging lung arterial disorder with remarkably high incidence and mortality rates, and the efficiency of current HPH treatment strategies is unsatisfactory. Endothelial-to-mesenchymal
Externí odkaz:
https://doaj.org/article/fdd37253054f4882a9007b15ee26ef07
Autor:
Mengdie Dong, Yunjia Zhang, Minghong Chen, Yongkang Tan, Jiao Min, Xian He, Fuhao Liu, Jiaming Gu, Hong Jiang, Longbin Zheng, Jiajing Chen, Quanwen Yin, Xuesong Li, Xiang Chen, Yongfeng Shao, Yong Ji, Hongshan Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3027-3048 (2024)
Endothelial-to-mesenchymal transition (EndMT) is a key driver of atherosclerosis. Aerobic glycolysis is increased in the endothelium of atheroprone areas, accompanied by elevated lactate levels. Histone lactylation, mediated by lactate, can regulate
Externí odkaz:
https://doaj.org/article/d3ba451a29bb44e98b710d533a1ad252
Autor:
Jinyan Yu, Shanchao Hong, Lingjia Yang, Shugao Ye, Zhen Yu, Zheming Zhang, Ziteng Wang, Shulun Huang, Yuan Chen, Tao Bian, Yan Wu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 23 (2024)
Background Hypoxia‐induced pulmonary hypertension (HPH) is a severe vascular disorder that is characterized by the involvement of endothelial‐to‐mesenchymal transition (EndMT) in its pathogenesis. Our previous research has suggested that the ge
Externí odkaz:
https://doaj.org/article/1c3fd786d0ae4f5997c7362798e1d55d
Autor:
William Y. Yang, Mohammed Ben Issa, Fatma Saaoud, Keman Xu, Ying Shao, Yifan Lu, Waleska Dornas, Ramon Cueto, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Pathological transdifferentiation, where differentiated cells aberrantly transform into other cell types that exacerbate disease rather than promote healing, represents a novel and significant concept. This perspective discusses its role and potentia
Externí odkaz:
https://doaj.org/article/6c44708d21ae49d1a2be22238d6b67b6
Publikováno v:
Materials Today Bio, Vol 28, Iss , Pp 101174- (2024)
Articular cartilage regeneration is a major challenge in orthopedic medicine. Endothelial progenitor cells (EPCs) are a promising cell source for regenerative medicine applications. However, their roles and functions in cartilage regeneration are not
Externí odkaz:
https://doaj.org/article/2be8b16d485244eab4bbf8db89dc3093