Molecular mechanisms of Dicer: endonuclease and enzymatic activity

Autor: Min-Sun Song, John J. Rossi

Publikováno v: Biochemical Journal

The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small interfering RNA, as well as a growing number of additional small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6d8e6406828f1a3f2d29b7c88493ec
http://europepmc.org/articles/PMC5415849

Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus

Autor: Michele Caraglia, Francesco Trepiccione, Anna Iervolino, Sabina Jelen, Mariavittoria D'Acierno, Robert A. Fenton, Lei Cheng, Giovambattista Capasso, Qi Wu, Fulvio D'Angelo, Vincenzo Costanzo, Maria Cristina Mazzarella, Alfonso De Falco, Michele Ceccarelli, Federica Petrillo, Ilaria Guerriero, Tiziana Angrisano

Publikováno v: J Am Soc Nephrol
Petrillo, F, Iervolino, A, Angrisano, T, Jelen, S, Costanzo, V, D’Acierno, M, Cheng, L, Wu, Q, Guerriero, I, Mazzarella, M C, De Falco, A, D’Angelo, F, Ceccarelli, M, Caraglia, M, Capasso, G, Fenton, R A & Trepiccione, F 2021, ' Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus ', Journal of the American Society of Nephrology, vol. 32, no. 6, pp. 1339-1354 . https://doi.org/10.1681/ASN.2020010031
Anna Iervolino, Tiziana Angrisano, Sabina Jelen, Vincenzo Costanzo, Mariavittoria D'Acierno, Lei Cheng, Qi Wu, Ilaria Guerriero, Maria Cristina Mazzarella, Alfonso De Falco, Fulvio D'Angelo, Michele Ceccarelli, Michele Caraglia, Giovambattista Capasso, Robert A Fenton & Francesco Trepiccione 2021, ' Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus ', Journal of the American Society of Nephrology : JASN . https://doi.org/10.1681/ASN.2020010031

Water reabsorption along the collecting duct is dependent on the function of aquaporin 2 (AQP2). Currently, information on microRNA (miRNA)-mediated, post-transcriptional regulation of AQP2, which may influence water reabsorption, is limited. In mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e9c6e26ba5abd3832bb1c626cb8bc7
https://pubmed.ncbi.nlm.nih.gov/33727367

Up-regulation of selenoprotein P and HIP/PAP mRNAs in hepatocytes by intermittent hypoxia via down-regulation of miR-203

Autor: Ryogo Shobatake, Shin Takasawa, Sumiyo Sakuramoto-Tsuchida, Tomoko Uchiyama, Mai Makino, Maiko Takeda, Asako Itaya-Hironaka, Chiho Ohbayashi, Hiroyo Ota, Hiroshi Kimura, Akiyo Yamauchi

Publikováno v: Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 130-137 (2017)
Biochemistry and Biophysics Reports

Sleep apnea syndrome is characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]) and is a risk factor for insulin resistance/type 2 diabetes. However, the mechanisms linking IH stress and insulin resist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80684ec0ff89d039608bf09e63678a22
http://www.sciencedirect.com/science/article/pii/S2405580817301139

Dicer1 is required for pigment cell and craniofacial development in zebrafish

Autor: Elisabeth M. Busch-Nentwich, Andrea M.J. Weiner, Tomás J. Steeman, Robert N. Kelsh, Christopher M. Dooley, Nadia L. Scampoli, Nora B. Calcaterra

Publikováno v: Weiner, A, Scampoli, N, Steeman, T, Dooley, C M, Busch-Nentwich, E, Kelsh, R N & Calcaterra, N 2019, ' Dicer1 is required for pigment cell and craniofacial development in zebrafish ', Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, vol. 1862, no. 4, pp. 472-485 . https://doi.org/10.1016/j.bbagrm.2019.02.005

The multidomain RNase III endoribonuclease DICER is required for the generation of most functional microRNAs (miRNAs). Loss of Dicer affects developmental processes at different levels. Here, we characterized the zebrafish Dicer1 mutant, dicer1sa9205

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd00f679cc62f220a34e3e7b2e068ca
https://purehost.bath.ac.uk/ws/files/190015254/1_s2.0_S1874939918305121_main.pdf

Dynamics of MicroRNA Biogenesis

Autor: Mohamed Fareh

Publikováno v: Biophysics of RNA-Protein Interactions ISBN: 9781493997244

MicroRNAs (miRNAs) are a class of short non-coding RNAs (~22 nt) that play important gene-regulatory functions in nearly all biological processes in eukaryotic organisms. Mature miRNAs are loaded into an Argonaute (Ago) protein effector and guide the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab4bbc2e8c014403d7168f7ec5e1eafa
https://doi.org/10.1007/978-1-4939-9726-8_10