Manifold effects of palmitoylcarnitine on endoplasmic reticulum metabolism: 11β-hydroxysteroid dehydrogenase 1, flux through hexose-6-phosphate dehydrogenase and NADPH concentration

Autor: Edmund Maser, Gail J. Mick, Kenneth McCormick, Xudong Wang

Publikováno v: The Biochemical journal. 437(1)

With the exception of the oxidation of G6P (glucose 6-phosphate) by H6PDH (hexose-6-phosphate dehydrogenase), scant information is available about other endogenous substrates affecting the redox state or the regulation of key enzymes which govern the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefe695f8d602cf90e1e689e8f147bfb
https://pubmed.ncbi.nlm.nih.gov/21492096

Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy

Autor: Hector Foronda, Yangxue Fu, Adriana Covarrubias-Pinto, Hartmut T. Bocker, Alexis González, Eric Seemann, Patricia Franzka, Andrea Bock, Ramachandra M. Bhaskara, Lutz Liebmann, Marina E. Hoffmann, Istvan Katona, Nicole Koch, Joachim Weis, Ingo Kurth, Joseph G. Gleeson, Fulvio Reggiori, Gerhard Hummer, Michael M. Kessels, Britta Qualmann, Muriel Mari, Ivan Dikić, Christian A. Hübner

Publikováno v: Nature
Foronda, H, Fu, Y, Covarrubias-Pinto, A, Bocker, H T, González, A, Seemann, E, Franzka, P, Bock, A, Bhaskara, R M, Liebmann, L, Hoffmann, M E, Katona, I, Koch, N, Weis, J, Kurth, I, Gleeson, J G, Reggiori, F, Hummer, G, Kessels, M M, Qualmann, B, Mari, M, Dikić, I & Hübner, C A 2023, ' Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy ', Nature, vol. 618, no. 7964, pp. 402-410 . https://doi.org/10.1038/s41586-023-06090-9

Membrane-shaping proteins characterized by reticulon homology domains play an important part in the dynamic remodelling of the endoplasmic reticulum (ER). An example of such a protein is FAM134B, which can bind LC3 proteins and mediate the degradatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587ec4f4d78e10eb10e252a8fb732491
https://doi.org/10.1038/s41586-023-06090-9

ER Membrane Contact Sites support endosomal small GTPase conversion for exosome secretion

Autor: Verweij, Frederik, Bebelman, Maarten P, George, Anna, Couty, Mickael, Bécot, Anaïs, Palmulli, Roberta, Heiligenstein, Xavier, Sires-Campos, Julia, Raposo, Graca, Pegtel, Dirk Michiel, Van Niel, Guillaume, Sub Cell Biology, Celbiologie

Publikováno v: The Journal of cell biology, 221(12):e202112032, 1-18. Rockefeller University Press
Verweij, F J, Bebelman, M P, George, A E, Couty, M, Bécot, A, Palmulli, R, Heiligenstein, X, Sirés-Campos, J, Raposo, G, Pegtel, D M & van Niel, G 2022, ' ER membrane contact sites support endosomal small GTPase conversion for exosome secretion ', Journal of Cell Biology, vol. 221, no. 12, e202112032 . https://doi.org/10.1083/jcb.202112032
Verweij, F J, Bebelman, M P, George, A E, Couty, M, Bécot, A, Palmulli, R, Heiligenstein, X, Sirés-Campos, J, Raposo, G, Pegtel, D M & van Niel, G 2022, ' ER membrane contact sites support endosomal small GTPase conversion for exosome secretion ', The Journal of cell biology, vol. 221, no. 12, e202112032, pp. 1-18 . https://doi.org/10.1083/jcb.202112032
Journal of Cell Biology, 221(12):e202112032. Rockefeller University Press
Journal of Cell Biology, 221(12), 1. Rockefeller University Press

Exosomes are endosome-derived extracellular vesicles involved in intercellular communication. They are generated as intraluminal vesicles within endosomal compartments that fuse with the plasma membrane (PM). The molecular events that generate secret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46e5d5a4c72e6d8647731eb57dd3dee
https://hdl.handle.net/1874/424418

Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum

Autor: Wouters, Rosanne, Michiels, Christine, Sannerud, Ragna, Kleizen, Bertrand, Dillen, Katleen, Vermeire, Wendy, Ayala, Abril, Demedts, David, Annaert, Wim, SCHEKMAN, Randy W

Publikováno v: The Journal of Cell Biology, vol 220, iss 9

γ-Secretase affects many physiological processes through targeting >100 substrates; malfunctioning links γ-secretase to cancer and Alzheimers disease. The spatiotemporal regulation of its stoichiometric assembly remains unresolved. Fractionation, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f2ae0199a715d64c89f2a0ccb4aace5c
https://dspace.library.uu.nl/handle/1874/414000

A Review of Mouse Models of Monogenic Diabetes and ER Stress Signaling

Autor: Salpea, Paraskevi, Cosentino, Cristina, Igoillo Esteve, Mariana

Publikováno v: Methods in molecular biology, 2128

Diabetes is a major public health problem: it is estimated that 420 million people are affected globally. Monogenic forms of diabetes are less common, but variants in monogenic diabetes genes have been shown to contribute to type 2 diabetes risk. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2101::4bc2c2ed6eba9b9fa8087714a0573669
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/326378