Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling

Autor: Josephine Elia, Grace Ungal, Charlly Kao, Alexander Ambrosini, Nilsa De Jesus-Rosario, Lene Larsen, Rosetta Chiavacci, Tiancheng Wang, Christine Kurian, Kanani Titchen, Brian Sykes, Sharon Hwang, Bhumi Kumar, Jacqueline Potts, Joshua Davis, Jeffrey Malatack, Emma Slattery, Ganesh Moorthy, Athena Zuppa, Andrew Weller, Enda Byrne, Yun R. Li, Walter K. Kraft, Hakon Hakonarson

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

Stimulant drugs are most commonly used to treat ADHD. Here, the authors demonstrate that in adolescents with ADHD who also have genetic variation in genes impacting metabotropic glutamate signaling, the non-stimulant mGluR activator fasoracetam is we

Externí odkaz: https://doaj.org/article/f704f752c78842ffbb277c912a01949b

Mitochondrial and Autosomal Genetic Analyses in the Australian Population

Autor: Enda Byrne

The central goal of human genetics is to understand genetic differences both within and between populations and how these differences contribute to phenotypic variation. Recent advances in genotyping technologies and statistical methodology mean that

Externí odkaz: http://espace.library.uq.edu.au/view/UQ:212831

8. EXPLORING GENETIC HETEROGENEITY OF DEPRESSION: SCALAR AND NON-SCALAR SNP EFFECTS IN THE GENETICS OF MILD VERSUS SEVERE DEPRESSION

Autor: Nick Martin, Brittany Mitchell, Sarah Medland, Enda Byrne, Naomi Wray, David Whiteman, Catherine Olsen, Ian Hickie

Publikováno v: European Neuropsychopharmacology. 63:e48

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b969ad8c96eec59f52517aae6e36348
https://doi.org/10.1016/j.euroneuro.2022.07.099

Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits

Autor: Joanna Martin, Ekaterina A. Khramtsova, Slavina B. Goleva, Gabriëlla A.M. Blokland, Michela Traglia, Raymond K. Walters, Christopher Hübel, Jonathan R.I. Coleman, Gerome Breen, Anders D. Børglum, Ditte Demontis, Jakob Grove, Thomas Werge, Janita Bralten, Cynthia M. Bulik, Phil H. Lee, Carol A. Mathews, Roseann E. Peterson, Stacey J. Winham, Naomi Wray, Howard J. Edenberg, Wei Guo, Yin Yao, Benjamin M. Neale, Stephen V. Faraone, Tracey L. Petryshen, Lauren A. Weiss, Laramie E. Duncan, Jill M. Goldstein, Jordan W. Smoller, Barbara E. Stranger, Lea K. Davis, Martin Alda, Marco Bortolato, Christie L. Burton, Enda Byrne, Caitlin E. Carey, Lauren Erdman, Laura M. Huckins, Manuel Mattheisen, Elise Robinson, Eli Stahl

Publikováno v: Martin, J, Khramtsova, E A, Goleva, S B, Blokland, G A M, Traglia, M, Walters, R K, Hübel, C, Coleman, J R I, Breen, G, Børglum, A D, Demontis, D, Grove, J, Werge, T, Bralten, J, Bulik, C M, Lee, P H, Mathews, C A, Peterson, R E, Winham, S J, Wray, N, Edenberg, H J, Guo, W, Yao, Y, Neale, B M, Faraone, S V, Petryshen, T L, Weiss, L A, Duncan, L E, Goldstein, J M, Smoller, J W, Stranger, B E, Davis, L K & Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium 2021, ' Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits ', Biological Psychiatry, vol. 89, no. 12, pp. 1127-1137 . https://doi.org/10.1016/j.biopsych.2020.12.024
Biological Psychiatry, 89, 1127-1137
Biological Psychiatry, 89, 12, pp. 1127-1137
Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium 2021, ' Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits ', Biological Psychiatry . https://doi.org/10.1016/j.biopsych.2020.12.024
Biological psychiatry, vol 89, iss 12
Biological Psychiatry, 89(12), 1127-1137. Elsevier Science
Biological Psychiatry

BackgroundThe origin of sex differences in prevalence and presentation of neuropsychiatric and behavioral traits is largely unknown. Given established genetic contributions and correlations across these traits, we tested for a sex-differentiated gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb7b1b8ccbc9ff843178132c7f83f9a
https://pure.au.dk/ws/files/277440930/1_s2.0_S0006322321000330_main.pdf

Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling

Autor: Nilsa De Jesus-Rosario, Andrew Weller, Joshua Davis, Emma Slattery, Tiancheng Wang, Lene Larsen, Sharon Hwang, Brian Sykes, Hakon Hakonarson, Jacqueline Potts, Enda Byrne, Rosetta M. Chiavacci, J. Jeffrey Malatack, Josephine Elia, Bhumi Kumar, Kanani Titchen, Athena F. Zuppa, Charlly Kao, Yun Li, Christine Kurian, Grace Ungal, Alexander Ambrosini, Walter K. Kraft, Ganesh S. Moorthy

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

The glutamatergic neurotransmitter system may play an important role in attention-deficit hyperactivity disorder (ADHD). This 5-week, open-label, single-blind, placebo-controlled study reports the safety, pharmacokinetics and responsiveness of the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57396efdedbded7a36a886713156cf75
http://europepmc.org/articles/PMC5770454