Frequently used bioinformatics tools overestimate the damaging effect of allelic variants

Autor: Trine H. Mogensen, Line Lykke Andersen, Veit Hornung, Nanna Mørk, Rune Hartmann, Klara Höning, Carsten Scavenius, Jan J. Enghild, Ewa Terczyńska-Dyla, Mette Christiansen

Publikováno v: Andersen, L L, Terczyńska-Dyla, E, Mørk, N, Scavenius, C, Enghild, J J, Höning, K, Hornung, V, Christiansen, M, Mogensen, T H & Hartmann, R 2019, ' Frequently used bioinformatics tools overestimate the damaging effect of allelic variants ', Genes and Immunity, vol. 20, no. 1, pp. 10-22 . https://doi.org/10.1038/s41435-017-0002-z

We selected two sets of naturally occurring human missense allelic variants within innate immune genes. The first set represented eleven non-synonymous variants in six different genes involved in interferon (IFN) induction, present in a cohort of pat

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https://doi.org/10.1038/s41435-017-0002-z