Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Encarna Matesanz"'
Autor:
Andrés A. Trabanco, Rosa M. Alvarez, Frans Eduard Janssens, Thomas Steckler, Inge Boeckx, Theo F. Meert, Laura Iturrino, Leenaerts Joseph Elisabeth, Antonio Gómez, Encarna Matesanz, Shirley Pullan, Ana Isabel de Lucas, Javier Fernández, J. Alonso, José Ignacio Andrés
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:146-149
A novel series of 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives has been prepared and their synthesis described herein. In vitro affinities for delta-, mu-, and kappa-opioid receptors, as well as the functional activity in the [(35)S]GTPgammaS
Autor:
J Ignacio Andrés, Jesús Alcázar, José M Alonso, Adolfo Dı́az, Javier Fernández, Pilar Gil, Laura Iturrino, Encarna Matesanz, Theo F Meert, Anton Megens, Victor K Sipido
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:249-253
Autor:
Javier Fernández, Nancy Aerts, Encarna Matesanz, Thomas Steckler, Andrés A. Trabanco, Shirley Pullan, Rosa M. Alvarez, Inge Boeckx, Antonio Gómez, Frans Eduard Janssens, José Ignacio Andrés, Ana Isabel de Lucas, Leenaerts Joseph Elisabeth
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(14)
Novel 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives have been prepared and their synthesis described herein. In vitro affinities for delta-, micro-, and kappa-opioid receptors are reported. Evaluation of some representative compounds from this
Autor:
Kristof Van Emelen, Jose M. Bartolomea, Jesús Alcázar, Marcel De Bruyn, J.Ignacio Andrés, Encarna Matesanz, Javier Fernández
Publikováno v:
ChemInform. 35
The synthesis of a series of novel analogues of the 3-substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridine core, modified in the non-aromatic ring, is described. Due to the presence of a versatile hydroxymethyl group in their structure, these novel sca
Autor:
J. Alonso, Anton Megens, José Ignacio Andrés, Encarna Matesanz, Pilar Gil, Victor K. Sipido, Laura Iturrino, Javier Fernández, Theo Meert, Andrés A. Trabanco, José María Cid
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(11)
Following the program started at Johnson & Johnson Pharmaceutical Research & Development searching for 5-HT2A/2C antagonists we now report on the synthesis of a series of substituted 2-(aminomethyl)-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]fu
Autor:
Didier de Chaffoy, Gustaaf Maria Boeckx, Gaston Stanislas Marcella Diels, Pedro Pardal Martínez, Davy Petrus Franciscus Maria Petit, Jean Pierre Frans Van Wauwe, Fred De Clerck, Marina Lucie Louise Cools, Anton Megens, José Manuel Alonso, Javier Fernández, Danielle Peeters, Adolfo Dı́az, Paul Stoppie, Laura Iturrino, Marijke Somers, F. Deroose, J. Ignacio Andres, Eddy Jean Edgard Freyne, Encarna Matesanz
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(4)
This communication describes the synthesis and in vitro PDE4 inhibitory activity of a novel series of imidazol-2-one and 2-cyanoiminoimidazole derivatives. The compounds described were also tested in in vivo models to evaluate their anti-inflammatory
Autor:
J Ignacio, Andrés, Jesús, Alcázar, José M, Alonso, Adolfo, Díaz, Javier, Fernández, Pilar, Gil, Laura, Iturrino, Encarna, Matesanz, Theo F, Meert, Anton, Megens, Victor K, Sipido
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(2)
Following the programme started at Janssen Research Foundation searching for 5-HT(2A/2C) antagonists, we now report on the synthesis of a series of substituted 2-(Dimethylaminomethyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives
Autor:
Encarna Matesanz, José Manuel Alonso, Jesús Alcázar, Pilar Gil, Laura Iturrino, J. Ignacio Andres, Javier Fernández, Victor Sipido, Theo F. Meert, Anton Megens, Adolfo Dı́az
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(2)
The synthesis of a series of novel 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives as well as their 5-HT(2A/2C) and H(1) receptor binding affinities are described. The in vivo activity as potential anxiolytics of the