Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Enas R. Abu-Zhayia"'
Autor:
Feras E. Machour, Enas R. Abu-Zhayia, Joyce Kamar, Alma Sophia Barisaac, Itamar Simon, Nabieh Ayoub
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The splicing factor RNA-binding motif protein 10 (RBM10) is frequently mutated in lung adenocarcinoma (LUAD) (9-25%). Most RBM10 cancer mutations are loss-of-function, correlating with increased tumorigenesis and limiting the efficacy of cur
Externí odkaz:
https://doaj.org/article/ae22363c12ae431e94e071bb14e3e944
Autor:
Enas R. Abu-Zhayia, Hanan Khoury-Haddad, Noga Guttmann-Raviv, Raphael Serruya, Nayef Jarrous, Nabieh Ayoub
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract DNA damage response (DDR) is needed to repair damaged DNA for genomic integrity preservation. Defective DDR causes accumulation of deleterious mutations and DNA lesions that can lead to genomic instabilities and carcinogenesis. Identifying n
Externí odkaz:
https://doaj.org/article/cc0874a55e194e5880efeaff330eb613
Autor:
Laila A. Bishara, Samah W. Awwad, Feras E. Machour, Tirza Bidany-Mizrahi, Nabieh Ayoub, Enas R Abu-Zhayia, Stefan Meinke, Rami I. Aqeilan, Florian Heyd
Publikováno v:
Nucleic Acids Research
Nucleic Acid Research
Nucleic Acid Research
RNA-binding proteins regulate mRNA processing and translation and are often aberrantly expressed in cancer. The RNA-binding motif protein 6, RBM6, is a known alternative splicing factor that harbors tumor suppressor activity and is frequently mutated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d4f7210d5bf18fb6d37867301f9247
http://europepmc.org/articles/PMC8599755
http://europepmc.org/articles/PMC8599755
SummaryPreviously, we showed that CDYL1 is recruited to DNA double-strand breaks (DSBs) to promote homology-directed repair (HDR) and foster transcriptional silencing. Yet, how CDYL1 elicits DSB-induced silencing is not fully understood. Here, we sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0516b43ff9194177d6dea4e23ac1c321
https://doi.org/10.1101/2021.05.31.446417
https://doi.org/10.1101/2021.05.31.446417
Autor:
Enas R, Abu-Zhayia, Laila A, Bishara, Feras E, Machour, Alma Sophia, Barisaac, Bella M, Ben-Oz, Nabieh, Ayoub
Publikováno v:
Molecular Cell. 82:1940-1955.e7
Previously, we showed that CDYL1 is recruited to DNA double-strand breaks (DSBs) to promote homologous recombination (HR) repair and foster transcriptional silencing. However, how CDYL1 elicits DSB-induced silencing is not fully understood. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3890b7e86b914340ea9f0c425f1868f3
https://doi.org/10.1016/j.molcel.2022.03.031
https://doi.org/10.1016/j.molcel.2022.03.031
Publikováno v:
Journal of Molecular Cell Biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e15a5b0cb579e4d393c741b4d53e12
https://doi.org/10.1093/jmcb/mjz019
https://doi.org/10.1093/jmcb/mjz019
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7a226bc02d5f5de3a4f367406c0386b
https://doi.org/10.1096/fasebj.2018.32.1_supplement.522.4
https://doi.org/10.1096/fasebj.2018.32.1_supplement.522.4
Publikováno v:
Journal of molecular cell biology. 10(4)
Cells have evolved DNA damage response (DDR) to repair DNA lesions and thus preserving genomic stability and impeding carcinogenesis. DNA damage induction is accompanied by transient transcription repression. Here, we describe a previously unrecogniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179b8f5fb4fa0793ea8c2bf002853041
https://pubmed.ncbi.nlm.nih.gov/29177481
https://pubmed.ncbi.nlm.nih.gov/29177481
Autor:
Nabieh Ayoub, Raphael Serruya, Noga Guttmann-Raviv, Hanan Khoury-Haddad, Nayef Jarrous, Enas R Abu-Zhayia
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
DNA damage response (DDR) is needed to repair damaged DNA for genomic integrity preservation. Defective DDR causes accumulation of deleterious mutations and DNA lesions that can lead to genomic instabilities and carcinogenesis. Identifying new player
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89e7c2f4b80a4d8daf82473d7b6e0f6
Double-strand breaks (DSBs) trigger rapid and transient transcription pause to prevent collisions between repair and transcription machineries at damage sites. Little is known about the mechanisms that ensure transcriptional block after DNA damage. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64f3220ea98920ceaa0b064a6e11f73
https://europepmc.org/articles/PMC5412775/
https://europepmc.org/articles/PMC5412775/