Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Enas Abu Shah"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The five-year survival rates for pancreatic ductal adenocarcinoma (PDAC) have scarcely improved over the last half-century. It is inherently resistant to FDA-approved immunotherapies, which have transformed the outlook for patients with other advance
Externí odkaz:
https://doaj.org/article/a3cd39fb9db74630b3238d3f5e118703
Autor:
Johannes Pettmann, Anna Huhn, Enas Abu Shah, Mikhail A Kutuzov, Daniel B Wilson, Michael L Dustin, Simon J Davis, P Anton van der Merwe, Omer Dushek
Publikováno v:
eLife, Vol 10 (2021)
T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and higher-affinity non-self peptides presented on major histocompatibility complex (pMHC) antigens. Although the discriminatory power of the TCR is widely believed
Externí odkaz:
https://doaj.org/article/bcd2f1d193024b08b393a17283f277a4
Autor:
Niv Ierushalmi, Maya Malik-Garbi, Angelika Manhart, Enas Abu Shah, Bruce L Goode, Alex Mogilner, Kinneret Keren
Publikováno v:
eLife, Vol 9 (2020)
Centering and decentering of cellular components is essential for internal organization of cells and their ability to perform basic cellular functions such as division and motility. How cells achieve proper localization of their organelles is still n
Externí odkaz:
https://doaj.org/article/fe062294b29646aa939cb012c89993c5
Autor:
Viveka Mayya, Edward Judokusumo, Enas Abu Shah, Christopher G. Peel, Willie Neiswanger, David Depoil, David A. Blair, Chris H. Wiggins, Lance C. Kam, Michael L. Dustin
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 340-349 (2018)
Summary: T cells engage in two modes of interaction with antigen-presenting surfaces: stable synapses and motile kinapses. Although it is surmised that durable interactions of T cells with antigen-presenting cells involve synapses, in situ 3D imaging
Externí odkaz:
https://doaj.org/article/dd677668e2df4a0db8e025ca66ed90b4
Autor:
Enas Abu Shah, Kinneret Keren
Publikováno v:
eLife, Vol 3 (2014)
The actin cortex plays a pivotal role in cell division, in generating and maintaining cell polarity and in motility. In all these contexts, the cortical network has to break symmetry to generate polar cytoskeletal dynamics. Despite extensive research
Externí odkaz:
https://doaj.org/article/a12a4b13e4894475944289153fd73044
Autor:
Ashwin Jainarayanan, Nithishwer Mouroug-Anand, Edward H. Arbe-Barnes, Adam J. Bush, Rachael Bashford-Rogers, Adam Frampton, Lara Heij, Mark Middleton, Michael L. Dustin, Enas Abu-Shah, Shivan Sivakumar
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106324- (2023)
Summary: Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer and has a 5-year survival of less than 8% owing to its complex biology. As PDAC is refractory to immunotherapy, we need to understand the functional dynamics of T
Externí odkaz:
https://doaj.org/article/492684cf49384aa1af081d9b639c1b81
Autor:
Arbel Artzy-Schnirman, Enas Abu-Shah, Rona Chandrawati, Efrat Altman, Norkhairin Yusuf, Shih-Ting Wang, Jose Ramos, Catherine S. Hansel, Maya Haus-Cohen, Rony Dahan, Sefina Arif, Michael L. Dustin, Mark Peakman, Yoram Reiter, Molly M. Stevens
Autoimmune diseases and in particular type 1 diabetes rely heavily on treatments that target the symptoms rather than prevent the underlying disease. One of the barriers to better therapeutic strategies is the inability to detect and efficiently targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668376355fb823a7a98113d810f80d10
http://hdl.handle.net/10044/1/96838
http://hdl.handle.net/10044/1/96838
Autor:
Tariq E. Khoyratty, Bin Xie, Gabriela Pirgova, Tal I. Arnon, Enas Abu-Shah, Andrew J. MacLean, Michael L. Dustin, Zhiyuan Hu, Pablo F. Céspedes, Ahmed Ashour Ahmed, Irina A. Udalova
Publikováno v:
The Journal of Immunology Author Choice
Key Points The Zinc finger protein, Zbtb18, is downregulated during PC differentiation. Enhanced expression of Zbtb18 leads to impaired PC development. Zbtb18 directly binds and inhibits expression of PI3K subunits.
The PI3K pathway plays a key
The PI3K pathway plays a key
Autor:
Johannes Pettmann, John Nguyen, Mikhail A Kutuzov, Philipp Kruger, Omer Dushek, Nicola Trendel, Enas Abu-Shah
Publikováno v:
The Journal of Immunology Author Choice
Key Points CD8+ T cells produce TNF-α, IL-2, and IFN-γ with similar Ag thresholds. Costimulation decreases Ag thresholds similarly for different cytokines. A common rate-limiting switch downstream of the TCR can explain these findings.
Visual
Visual
Autor:
Silvia Jansen, Enas Abu-Shah, Alex Mogilner, Bruce L. Goode, Kinneret Keren, Maya Malik-Garbi, Niv Ierushalmi
Publikováno v:
Nature physics
Contractile actomyosin network flows are crucial for many cellular processes including cell division and motility, morphogenesis and transport. How local remodelling of actin architecture tunes stress production and dissipation and regulates large-sc