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Akademický článek

Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

Autor: Raffaello Verardi, Lisa C. Lindesmith, Yaroslav Tsybovsky, Jason Gorman, Gwo-Yu Chuang, Caitlin E. Edwards, Paul D. Brewer-Jensen, Michael L. Mallory, Li Ou, Arne Schön, Wei Shi, Ena S. Tully, George Georgiou, Ralph S. Baric, Peter D. Kwong

Publikováno v: npj Vaccines, Vol 5, Iss 1, Pp 1-10 (2020)

Abstract Human noroviruses are non-enveloped, single-strand RNA viruses that cause pandemic outbreaks of acute gastroenteritis. A bivalent vaccine containing GI.1 and GII.4 virus-like particles (VLPs) has been shown to be safe and highly immunogenic,

Externí odkaz: https://doaj.org/article/291f486fe191490c902890335db78af5

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Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

Autor: George Georgiou, Raffaello Verardi, Caitlin E. Edwards, Ena S Tully, Peter D. Kwong, Jason Gorman, Gwo-Yu Chuang, Ralph S. Baric, Michael L. Mallory, Yaroslav Tsybovsky, Paul D. Brewer-Jensen, Li Ou, Arne Schön, Wei Shi, Lisa C. Lindesmith

Publikováno v: npj Vaccines, Vol 5, Iss 1, Pp 1-10 (2020)
NPJ Vaccines

Human noroviruses are non-enveloped, single-strand RNA viruses that cause pandemic outbreaks of acute gastroenteritis. A bivalent vaccine containing GI.1 and GII.4 virus-like particles (VLPs) has been shown to be safe and highly immunogenic, but its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d494a39543761a9936397d349dcf51e6
https://doi.org/10.1038/s41541-020-00260-w

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Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential

Autor: J. Silvio Gutkind, Brittany A. Tang, Sheng Li, Brenna L. Barton, Nadia Arang, Sumit J. Bandekar, Ena S. Tully, John J.G. Tesmer

Publikováno v: Science signaling. 12(569)

The C-terminal guanine nucleotide exchange factor (GEF) module of Trio (TrioC) transfers signals from the Gα(q/11) subfamily of heterotrimeric G proteins to the small guanosine triphosphatase (GTPase) RhoA, enabling Gα(q/11)-coupled G protein–cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12876aa8d0ebaa52089cd109bfb3c8e0
https://pubmed.ncbi.nlm.nih.gov/30783010

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