Zobrazeno 1 - 10
of 180
pro vyhledávání: '"En-Yin Lai"'
Autor:
Chengxian Xu, Lingxiao Tong, Jia Rao, Qing Ye, Yuxia Chen, Yingying Zhang, Jie Xu, Xiaoting Mao, Feilong Meng, Huijun Shen, Zhihong Lu, Xiaohui Cang, Haidong Fu, Shugang Wang, Weiyue Gu, En-Yin Lai, Min-Xin Guan, Pingping Jiang, Jianhua Mao
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
Inherited kidney diseases are the fifth most common cause of end-stage renal disease (ESRD). Mitochondrial dysfunction plays a vital role in the progression of inherited kidney diseases, while mitochondrial-transfer RNA (mt-tRNA) variants and their p
Externí odkaz:
https://doaj.org/article/286b853126764869b70ca5a635131c91
Autor:
Lu Lu, Lin Yang, Ya-Ping Lu, Qin Jiang, Cui-Rong Wang, Cui-Qing Liu, Nan Xu, Shan Jiang, Gang Zhang, En-Yin Lai, Feng Han, Ying-Mei Lu
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 219, Iss , Pp 112314- (2021)
PM2.5 infiltrates into circulation and increases the risk of systemic vascular dysfunction. As the first-line barrier against external stimuli, the molecular mechanism of the biological response of vascular endothelial cells to PM2.5 exposure remains
Externí odkaz:
https://doaj.org/article/5ae088b7c41742deacf9c36e0df73f4a
Autor:
Yan Wu, Junjun Luan, Congcong Jiao, Shiwen Zhang, Cong Ma, Yixiao Zhang, Jingqi Fu, En Yin Lai, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Renal tubulointerstitial fibrosis is a common pathological feature of progressive chronic kidney disease (CKD), and current treatment has limited efficacy. The circular RNA circHIPK3 is reported to participate in the pathogenesis of various human dis
Externí odkaz:
https://doaj.org/article/bc2d42004d6b4b9e9c1fdbbe4e09e81e
Autor:
Nan Xu, Qin Wang, Shan Jiang, Qijing Wang, Weipeng Hu, Suhan Zhou, Liang Zhao, Lanyu Xie, Jianghua Chen, Anton Wellstein, En Yin Lai
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 87-97 (2019)
Fenofibrate, a peroxisome proliferator-activated receptors α (PPARα) agonist, reduces vascular complications of diabetic patients but its protective mechanisms are not fully understood. Here we tested the hypothesis that fenofibrate improves vascul
Externí odkaz:
https://doaj.org/article/5d125c188c514ccaa789d895ea25fdca
Autor:
Gensheng Zhang, Qin Wang, Wenwen Wang, Minghua Yu, Suping Zhang, Nan Xu, Suhan Zhou, Xiaoyun Cao, Xiaodong Fu, Zufu Ma, Ruisheng Liu, Jianhua Mao, En Yin Lai
Publikováno v:
Kidney & Blood Pressure Research, Vol 43, Iss 3, Pp 904-913 (2018)
Background/Aims: Free radical scavenger tempol is a protective antioxidant against ischemic injury. Tubular epithelial apoptosis is one of the main changes in the renal ischemia/reperfusion (I/R) injury. Meanwhile some proteins related with apoptosis
Externí odkaz:
https://doaj.org/article/126411d06f46443199b951ac738f0d53
Autor:
Suping Zhang, Qian Huang, Qiaoling Wang, Qin Wang, Xiaoyun Cao, Liang Zhao, Nan Xu, Zhengbing Zhuge, Jianhua Mao, Xiaodong Fu, Ruisheng Liu, Christopher S. Wilcox, Andreas Patzak, Lingli Li, En Yin Lai
Publikováno v:
Kidney & Blood Pressure Research, Vol 43, Iss 3, Pp 860-871 (2018)
Background/Aims: Canonical Wnt signaling is involved in oxidative stress, vasculopathy and diabetes mellitus but its role in diabetic renal microvascular dysfunction is unclear. We tested the hypothesis that enhanced canonical Wnt signaling in renal
Externí odkaz:
https://doaj.org/article/8cafebed68a0479c8e90ab929e0b3677
Autor:
Ting Li, Ying Bao, Yu Xia, Hanyan Meng, Chao Zhou, Limin Huang, Xiaowen Wang, En Yin Lai, Pingping Jiang, Jianhua Mao
Publikováno v:
International Journal of Biological Sciences; 2024, Vol. 20 Issue 3, p937-952, 16p
Autor:
Lingxia Zhang, Shugang Wang, Ruoque Mao, Haidong Fu, Jingjing Wang, Huijun Shen, Zhihong Lu, Junyi Chen, Yu Bao, Chunyue Feng, En Yin Lai, Qing Ye, Jianhua Mao
Publikováno v:
Genetics Research. 2022:1-10
Background. Both Lowe syndrome and Dent-2 disease are caused by variants in the OCRL gene. However, the reason why patients with similar OCRL gene mutations presented with different phenotypes remains uncertain. Methods. Children with hemizygous path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cd4e0c2e8f15a2ea087c50395a5481
https://doi.org/10.1155/2022/1473260
https://doi.org/10.1155/2022/1473260
Autor:
Xiaofei Zhou, Yuanqing Jiang, Yuewen Wang, Linge Fan, Yunhui Zhu, Yefeng Chen, Yiran Wang, Yingyi Zhu, Hongkun Wang, Zihang Pan, Zhoubin Li, Xiaolong Zhu, Ruizhe Ren, Zhen Ge, Dongwu Lai, En Yin Lai, Ting Chen, Kai Wang, Ping Liang, Lingfeng Qin
Publikováno v:
Circulation Research; Sep2023, Vol. 133 Issue 6, p508-531, 24p
Targeting Dynamin 2 as a Novel Pathway to Inhibit Cardiomyocyte Apoptosis Following Oxidative Stress
Publikováno v:
Cellular Physiology and Biochemistry, Vol 39, Iss 6, Pp 2121-2134 (2016)
Background/Aims: Inhibition of Drp-1-mediated mitochondrial fission limits reactive oxygen species (ROS) production and apoptosis in cardiomyocytes subjected to ischemia/reperfusion injury. It remains unknown if Dynamin 2 inhibition results in simila
Externí odkaz:
https://doaj.org/article/6025739a61fb41ae8d527c499e57c266