Zobrazeno 1 - 10
of 24
pro vyhledávání: '"En-Ching Luo"'
Autor:
Corina E. Antal, Tae Gyu Oh, Stefan Aigner, En-Ching Luo, Brian A. Yee, Tania Campos, Hervé Tiriac, Katherine L. Rothamel, Zhang Cheng, Henry Jiao, Allen Wang, Nasun Hah, Elizabeth Lenkiewicz, Jan C. Lumibao, Morgan L. Truitt, Gabriela Estepa, Ester Banayo, Senada Bashi, Edgar Esparza, Ruben M. Munoz, Jolene K. Diedrich, Nicole M. Sodir, Jasmine R. Mueller, Cory R. Fraser, Erkut Borazanci, David Propper, Daniel D. Von Hoff, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Haiyong Han, Andrew M. Lowy, Michael T. Barrett, Dannielle D. Engle, Gerard I. Evan, Gene W. Yeo, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here we uncover a druggable SE
Externí odkaz:
https://doaj.org/article/57cc744cc0404cd39ed1bebee4e6eee7
Autor:
Michelle M. Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G. Fox, Ashley A. Adile, David Bakhshinyan, Kevin Brown, William D. Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam Fleming, Kristin Hope, John P. Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J. Wechsler-Reya, Gene W. Yeo, Sheila K. Singh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
MYC amplification is an independent prognostic factor for the most aggressive subgroup (Group 3) of pediatric medulloblastoma (G3 MB). Here, the authors highlight the role of the RNA-binding protein, Musashi-1 (MSI1) in G3 MB and identify MSI1-bound
Externí odkaz:
https://doaj.org/article/3eace71e4f774decb598d79c690ed3aa
Autor:
Michelle M. Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G. Fox, Ashley A. Adile, David Bakhshinyan, Kevin Brown, William D. Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam Fleming, Kristin Hope, John P. Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J. Wechsler-Reya, Gene W. Yeo, Sheila K. Singh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a3f8e3d5b4894e4aa4350454d71f0f4e
Autor:
Yi-Jyun Liu, Yu-Fen Lin, Yi-Fan Chen, En-Ching Luo, Yuh-Ping Sher, Mong-Hsun Tsai, Eric Y Chuang, Liang-Chuan Lai
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62383 (2013)
Lung cancer is the leading cause of cancer-related mortality worldwide. Radiotherapy is often applied for treating lung cancer, but it often fails because of the relative non-susceptibility of lung cancer cells to radiation. MicroRNAs (miRNAs) have b
Externí odkaz:
https://doaj.org/article/0048e603476d461c889e3492a83d956e
Autor:
Gene Yeo, Joy Xiang, Jasmine Mueller, En-Ching Luo, Brian Yee, Danielle Schafer, Jonathan Schmok, Frederick Tan, Katherine Rothamel, Rachael McVicar, Elizabeth Kwong, Ben Croker, Krysten Jones, Hsuan-Lin Her, Chun-Yuan Chen, Anthony Vu, Wenhao Jin, Samuel Park, Phuong Le, Kristopher Brennan, Eric Kofman, Yanhua Li, Alexandra Tankka, Kevin Dong, Yan Song, Alex Clark, Aaron Carlin, Eric Van Nostrand, Sandra Leibel
The COVID-19 pandemic is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The betacoronvirus has a positive sense RNA genome which encodes for several RNA binding proteins. Here, we use enhanced crosslinking and immunoprecipita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117a420792f31767c78616cc9348e34c
https://doi.org/10.21203/rs.3.rs-1394331/v1
https://doi.org/10.21203/rs.3.rs-1394331/v1
Autor:
Joy S. Xiang, Jasmine R. Mueller, En-Ching Luo, Brian A. Yee, Danielle Schafer, Jonathan C. Schmok, Frederick E. Tan, Katherine Rothamel, Rachael N. McVicar, Elizabeth M. Kwong, Krysten L. Jones, Hsuan-Lin Her, Chun-Yuan Chen, Anthony Q. Vu, Wenhao Jin, Samuel S. Park, Phuong Le, Kristopher W. Brannan, Eric R. Kofman, Yanhua Li, Alexandra T. Tankka, Kevin D. Dong, Yan Song, Aaron F. Carlin, Eric L. Van Nostrand, Sandra L. Leibel, Gene W. Yeo
Publikováno v:
bioRxiv : the preprint server for biology.
The COVID-19 pandemic is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The betacoronvirus has a positive sense RNA genome which encodes for several RNA binding proteins. Here, we use enhanced crosslinking and immunoprecipita
Autor:
Eric L. Van Nostrand, Jeanine L. Van Nostrand, En-Ching Luo, Kristina Hellberg, Jingting Yu, Yelena Dayn, Reuben J. Shaw, Alina Dayn, Gene W. Yeo, Maxim N. Shokhirev
Publikováno v:
Genes Dev
Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic bene
Autor:
En-Ching Luo, Anthony Q. Vu, Eric Kofman, Sandra L Leibel, Aaron F. Carlin, Eric L. Van Nostrand, Jonathan C. Schmok, Elizabeth M. Kwong, Danielle Schafer, Brian A. Yee, Gene W. Yeo, Jasmine R. Mueller, Frederick E. Tan, Joy Shengnan Xiang, Yan Song, Kristopher W. Brannan, Alexandra T. Tankka, Yanhua Li, Phuong Le, Kevin D. Dong, Hsuan-Lin Her, Samuel S. Park, Krysten Leigh Jones, Rachael N. McVicar, Chun-Yuan Chen, Wenhao Jin
Publikováno v:
SSRN Electronic Journal.
The COVID-19 pandemic was caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Here, we use enhanced crosslinking and immunoprecipitation to investigate SARS-CoV-2 protein interactions with viral and host RNAs. SARS-CoV-2 proteins,
Autor:
Sebastian Markmiller, Joshua L. Schwartz, David E. Hill, Gene W. Yeo, Archana Shankar, Jonathan C. Schmok, Gabriel A. Pratt, Duy B. Scaletta, Brian A. Yee, Stefan Aigner, Frederick E. Tan, Shashank Sathe, Jason L. Nathanson, Yuanchi Ha, En-Ching Luo
Publikováno v:
Nature structural & molecular biology, vol 27, iss 10
Nat Struct Mol Biol
Nat Struct Mol Biol
The molecular functions of the majority of RNA-binding proteins (RBPs) remain unclear, highlighting a major bottleneck to a full understanding of gene expression regulation. Here, we develop a plasmid resource of 690 human RBPs that we subject to luc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c24a6237dec4ffeb782ed4b0b5f261
https://escholarship.org/uc/item/5kd0v4kq
https://escholarship.org/uc/item/5kd0v4kq
Autor:
Nishani Rajakulendran, Gene W. Yeo, Stephane Angers, Nevraj S. Kejiou, Lena Ilan, Stefan Aigner, En-Ching Luo, Ines Rabano, Alexander F. Palazzo, Hamed S. Najafabadi
How human cells coordinate various metabolic processes, such as glycolysis and protein translation, remains unclear. One key insight is that various metabolic enzymes have been found to associate with mRNAs, however whether these enzymes regulate mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd60a268e230306a8eea30ac543cfeb
https://doi.org/10.1101/715086
https://doi.org/10.1101/715086