Zobrazeno 1 - 10
of 385
pro vyhledávání: '"En‐min Li"'
Autor:
Yueyuan Zheng, Benjamin Ziman, Allen S. Ho, Uttam K. Sinha, Li-Yan Xu, En-Min Li, H Phillip Koeffler, Benjamin P. Berman, De-Chen Lin
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-31 (2023)
Abstract Background As one of the most common malignancies, esophageal cancer has two subtypes, squamous cell carcinoma and adenocarcinoma, arising from distinct cells-of-origin. Distinguishing cell-type-specific molecular features from cancer-specif
Externí odkaz:
https://doaj.org/article/6b59f1cedad94224a5e59061095d1407
Autor:
Jian-Zhong He, Yang Chen, Fa-Min Zeng, Qing-Feng Huang, Hai-Feng Zhang, Shao-Hong Wang, Shuai-Xia Yu, Xiao-Xiao Pang, Ye Liu, Xiu-E Xu, Jian-Yi Wu, Wen-Jun Shen, Zhan-Yu Li, En-Min Li, Li-Yan Xu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-18 (2023)
Abstract Background Increasing evidence indicates that the tumor microenvironment (TME) is a crucial determinant of cancer progression. However, the clinical and pathobiological significance of stromal signatures in the TME, as a complex dynamic enti
Externí odkaz:
https://doaj.org/article/792d8f46a03f4688a39abb48e3a16a13
Publikováno v:
Cancer Communications, Vol 42, Iss 7, Pp 668-672 (2022)
Externí odkaz:
https://doaj.org/article/611209c56867453ea3a3075f3fa461d1
Autor:
Zhen-Yuan Zheng, Man-Yu Chu, Wan Lin, Ya-Qi Zheng, Xiu-E Xu, Yang Chen, Lian-Di Liao, Zhi-Yong Wu, Shao-Hong Wang, En-Min Li, Li-Yan Xu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-14 (2022)
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the world’s leading causes of death, and its primary clinical therapy relies on surgical resection, chemotherapy, radiotherapy, and chemoradiotherapy. Although the genomic features and cl
Externí odkaz:
https://doaj.org/article/a58d23d2d0ee4563aac4fb99ebbcad7a
Autor:
Huy Q. Dinh, Feng Pan, Geng Wang, Qing-Feng Huang, Claire E. Olingy, Zhi-Yong Wu, Shao-Hong Wang, Xin Xu, Xiu-E Xu, Jian-Zhong He, Qian Yang, Sandra Orsulic, Marcela Haro, Li-Yan Li, Guo-Wei Huang, Joshua J. Breunig, H. Phillip Koeffler, Catherine C. Hedrick, Li-Yan Xu, De-Chen Lin, En-Min Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The microenvironment of oesophageal squamous cell carcinomas (ESCC) is heterogeneous and can strongly impact response to treatment. Here, the authors characterize the ESCC tumour microenvironment with single-cell RNA-seq, finding CST1 + myofibroblast
Externí odkaz:
https://doaj.org/article/2e80dc52b5e14a5c9cab19a0f4a82e35
Autor:
Yin‐Wei Cheng, Fa‐Min Zeng, Da‐Jia Li, Shao‐Hong Wang, Jian‐Zhong He, Zhen‐Chang Guo, Ping‐Juan Nie, Zhi‐Yong Wu, Wen‐Qi Shi, Bing Wen, Xiu‐E Xu, Lian‐Di Liao, Zhi‐Mao Li, Jian‐Yi Wu, Jun Zhan, Hong‐Quan Zhang, Zhi‐Jie Chang, Kai Zhang, Li‐Yan Xu, En‐Min Li
Publikováno v:
Cancer Communications, Vol 41, Iss 12, Pp 1398-1416 (2021)
Abstract Background Fascin is crucial for cancer cell filopodium formation and tumor metastasis, and is functionally regulated by post‐translational modifications. However, whether and how Fascin is regulated by acetylation remains unclear. This st
Externí odkaz:
https://doaj.org/article/396cbf9cf8724588809cbca5a4d2628a
Autor:
Ji-Wei Jiao, Xiu-Hui Zhan, Juan-Juan Wang, Li-Xia He, Zhen-Chang Guo, Xiu-E Xu, Lian-Di Liao, Xin Huang, Bing Wen, Yi-Wei Xu, Hai Hu, Gera Neufeld, Zhi-Jie Chang, Kai Zhang, Li-Yan Xu, En-Min Li
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102496- (2022)
Lysyl-oxidase like-2 (LOXL2) regulates extracellular matrix remodeling and promotes tumor invasion and metastasis. Altered metabolism is a core hallmark of cancer, however, it remains unclear whether and how LOXL2 contributes to tumor metabolism. Her
Externí odkaz:
https://doaj.org/article/4845795eb09b42b2917759efefea0337
Autor:
Wei Liu, Lei Xie, Yao-Hui He, Zhi-Yong Wu, Lu-Xin Liu, Xue-Feng Bai, Dan-Xia Deng, Xiu-E Xu, Lian-Di Liao, Wan Lin, Jing-Hua Heng, Xin Xu, Liu Peng, Qing-Feng Huang, Cheng-Yu Li, Zhi-Da Zhang, Wei Wang, Guo-Rui Zhang, Xiang Gao, Shao-Hong Wang, Chun-Quan Li, Li-Yan Xu, Wen Liu, En-Min Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Proteomics can aid in the identification of molecular subtypes in cancers. Here, the authors perform proteomic profiling of 124 paired oesophageal cancer and adjacent non-tumour tissues and identify two subtypes that are associated with patient survi
Externí odkaz:
https://doaj.org/article/9d695a233ef54642ace9e04ed24b5883
Autor:
Yang Chen, Li-Xia He, Jin-Ling Chen, Xin Xu, Juan-Juan Wang, Xiu-Hui Zhan, Ji-Wei Jiao, Geng Dong, En-Min Li, Li-Yan Xu
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104894- (2022)
Summary: Obesity is primarily characterized by the dysregulation of lipid metabolism and gut microbiota. Here, we found that the body weight of transgenic mice overexpressing L2Δ13, a selectively spliced isoform of lysyl oxidase-like 2 (LOXL2), was
Externí odkaz:
https://doaj.org/article/c0027bf9be554e089add50ea38bfc0b3
Autor:
Li-Yan Li, Qian Yang, Yan-Yi Jiang, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guo-Wei Huang, Xiu-E Xu, Sigal Gery, Ying Zhang, Ling-Wen Ding, Allen S. Ho, Zachary S. Zumsteg, Ming-Rong Wang, Melissa J. Fullwood, Stephen J. Freedland, Stephen J. Meltzer, Li-Yan Xu, En-Min Li, H. Phillip Koeffler, De-Chen Lin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The relevance and underlying molecular mechanisms of epigenetic regulation in squamous cell carcinomas (SCC) await further characterization. Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenes
Externí odkaz:
https://doaj.org/article/bb5f76c06e2f4727bd8409644acda48f