Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Emptoz-Bonneton A"'
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Akademický článek
In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts
Autor: Ghina Alameh, Agnès Emptoz-Bonneton, Marc Rolland de Ravel, Eva L. Matera, Elisabeth Mappus, Patrick Balaguer, Luc Rocheblave, Thierry Lomberget, Charles Dumontet, Marc Le Borgne, Michel Pugeat, Catherine Grenot, Claude Y. Cuilleron
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 684-691 (2019)
Synthetic progesterone and 5α/β-pregnane-3,20-dione derivatives were evaluated as in vitro and in vivo modulators of multidrug-resistance (MDR) using two P-gp-expressing human cell lines, the non-steroidogenic K562/R7 erythroleukaemia cells and the
Externí odkaz: https://doaj.org/article/55b0290ee7904a11adb07838554e6862
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2
Akademický článek
In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts.
Autor: Alameh, Ghina1 (AUTHOR), Emptoz-Bonneton, Agnès1,2 (AUTHOR), Rolland de Ravel, Marc1,3 (AUTHOR), Matera, Eva L.3 (AUTHOR), Mappus, Elisabeth1 (AUTHOR), Balaguer, Patrick4 (AUTHOR), Rocheblave, Luc1,5 (AUTHOR), Lomberget, Thierry1,5 (AUTHOR), Dumontet, Charles3 (AUTHOR), Le Borgne, Marc5 (AUTHOR) marc.le-borgne@univ-lyon1.fr, Pugeat, Michel1,2 (AUTHOR), Grenot, Catherine1 (AUTHOR), Cuilleron, Claude Y.1 (AUTHOR) yves.cuilleron@inserm.fr
Publikováno v: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2019, Vol. 34 Issue 1, p684-691. 8p.
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3
In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts
Autor: Luc Rocheblave, Thierry Lomberget, Patrick Balaguer, Charles Dumontet, Eva Laure Matera, Catherine Grenot, Claude Y Cuilleron, Ghina Alameh, E Mappus, Agnès Emptoz-Bonneton, Michel Pugeat, Marc Rolland de Ravel, Marc Le Borgne
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2019, 34 (1), pp.684-691. ⟨10.1080/14756366.2019.1575825⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.684-691. ⟨10.1080/14756366.2019.1575825⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 684-691 (2019)
International audience; Synthetic progesterone and 5α/β-pregnane-3,20-dione derivatives were evaluated as in vitro and in vivo modulators of multidrug-resistance (MDR) using two P-gp-expressing human cell lines, the non-steroidogenic K562/R7 erythr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f99c031fa0528de7af7dd78aa823532
https://hal.archives-ouvertes.fr/hal-02077612/document
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4
Synthesis of new steroidal inhibitors of P-glycoprotein-mediated multidrug resistance and biological evaluation on K562/R7 erythroleukemia cells
Autor: Sonia Beltran, Nadia Walchshofer, Marc Le Borgne, Roland Barret, Agnès Emptoz-Bonneton, Charles Dumontet, Michel Pugeat, Catherine Grenot, Zahia Mahiout, Maxime Melikian, Eva-Laure Matera, Lucienne El Jawad, Ghina Alameh, Elisabeth Mappus, Luc Rocheblave, Marc Rolland de Ravel, Claude Yves Cuilleron, Thierry Lomberget
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (4), pp.1832-1845. ⟨10.1021/jm501676v⟩
A simple route for improving the potency of progesterone as a modulator of P-gp-mediated multidrug resistance was established by esterification or etherification of hydroxylated 5α/β-pregnane-3,20-dione or 5β-cholan-3-one precursors. X-ray crystal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195f7e504ec6642dbda35ee91f446dd4
https://pubmed.ncbi.nlm.nih.gov/25634041
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5
Corticosteroid Binding Globulin: A New Target for Cortisol-Driven Obesity
Autor: Nathalie Iannuccelli, Patrick Chardon, Denis Milan, Olga Ousova, Pierre Mormède, Martine Yerle, Véronique Guyonnet-Dupérat, Jean Pierre Bidanel, Marie-Pierre Moisan, Agnès Emptoz-Bonneton, C Genêt, Bastien Llamas, Joël Gellin, Michel Pugeat
Publikováno v: Molecular Endocrinology 7 (18), 1687-1696. (2004)
Molecular Endocrinology-Baltimore
Molecular Endocrinology-Baltimore-, Endocrine Society, In press, 18 (7), pp.1687-1696
HAL
Molecular Endocrinology-Baltimore-, 2004, 18 (7), pp.1687-1696. ⟨10.1210/me.2004-0005⟩
We present data suggesting that corticosteroid-binding globulin (CBG) may be the causal gene of a previously identified quantitative trait locus (QTL) associated with cortisol levels, fat, and muscle content in a pig intercross. Because Cbg in human
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2aeebf7bdad1282f744eb9d44ec0f2e
https://doi.org/10.1210/me.2004-0005
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6
Influence ofSHBGGene Pentanucleotide TAAAA Repeat and D327N Polymorphism on Serum Sex Hormone-Binding Globulin Concentration in Hirsute Women
Autor: Hervé Lejeune, Patrice Cousin, Gérald Raverot, Laurence Calemard-Michel, Agnès Emptoz-Bonneton, Nadia Yessaad, Yves Morel, Michel Pugeat
Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 89:917-924
SHBG is the specific plasma transport protein for sex steroid hormones in humans. Plasma SHBG concentration follows a gender dimorphism but varies with nutritional and hormonal status in both sexes. In addition, a genetic influence on SHBG in humans
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fd88f2105881627def7d3e0ebfa7e1
https://doi.org/10.1210/jc.2002-021553
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7
Novel Human Corticosteroid-Binding Globulin Variant with Low Cortisol-Binding Affinity1
Autor: Chantal Bully, Patrice Cousin, George V. Avvakumov, Koji Seguchi, Geoffrey L. Hammond, Agnès Emptoz-Bonneton, Michel Pugeat
Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 85:361-367
Corticosteroid-binding globulin (CBG) is the plasma transport protein that regulates the access of glucocorticoid hormones to target cells. Genetic deficiencies of CBG are rare, and only a single human CBG variant (Trancortin Leuven) has been related
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::326e7254c4586d7c4f37b51a53490079
https://doi.org/10.1210/jcem.85.1.6315
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8
Decreased corticosteroid-binding globulin in burn patients
Autor: Dominique R. Garrel, Nathalie Jobin, Michel Pugeat, Agnès Emptoz-Bonneton, Jacques Bernier
Publikováno v: Critical Care Medicine. 26:452-460
To analyze the effect of low-fat nutritional solutions, with or without fish oil, on serum interleukin (IL)-6, and to explore the relationships between IL-6, corticosteroid-binding globulin (CBG; the main cortisol carrier in plasma), and protein meta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f0bcf41dc026957583b28b6cb39938
https://doi.org/10.1097/00003246-199803000-00014
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10
Improved Clinical Status and Length of Care With Low-Fat Nutrition Support in Burn Patients
Autor: François Larivière, Agnès Emptoz-Bonneton, Nazem Naman, Nathalte Jobin, Michel Pugeat, Mohammad Razi, Dominique R. Garrel
Publikováno v: Journal of Parenteral and Enteral Nutrition. 19:482-491
The optimal amount and type of fat in the nutrition support of burned patients have not been determined. The aim of this study was to test low-fat nutritional solutions, with or without fish oil, on protein metabolism, morbidity, and length of care i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5bb447ee754132d672cd05fe228e0f
https://doi.org/10.1177/0148607195019006482
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