Clustering of Alzheimer's and Parkinson's disease based on genetic burden of shared molecular mechanisms.

Autor: Emon MA; Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), 53754, Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, University of Bonn, Endenicher Allee 19c, 53115, Bonn, Germany., Heinson A; UCB Pharma (UCB Celltech Ltd.), 208 Bath Road, Slough, SL1 3WE, Berkshire, UK., Wu P; UCB Pharma (UCB Celltech Ltd.), 208 Bath Road, Slough, SL1 3WE, Berkshire, UK., Domingo-Fernández D; Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), 53754, Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, University of Bonn, Endenicher Allee 19c, 53115, Bonn, Germany., Sood M; Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), 53754, Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, University of Bonn, Endenicher Allee 19c, 53115, Bonn, Germany., Vrooman H; Department of Radiology and Nuclear Medicine, Department of Medical Informatics, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands., Corvol JC; ICM - Hôpital Pitié Salpêtrière, 47, bd de l'hôpital, 75013, Paris, France., Scordis P; UCB Pharma (UCB Celltech Ltd.), 208 Bath Road, Slough, SL1 3WE, Berkshire, UK., Hofmann-Apitius M; Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), 53754, Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, University of Bonn, Endenicher Allee 19c, 53115, Bonn, Germany., Fröhlich H; Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), 53754, Sankt Augustin, Germany. holger.froehlich@scai.fraunhofer.de.; Bonn-Aachen International Center for IT, University of Bonn, Endenicher Allee 19c, 53115, Bonn, Germany. holger.froehlich@scai.fraunhofer.de.; UCB Pharma (UCB Biosciences GmbH), Alfred-Nobel-Str. 10, 40789, Monheim, Germany. holger.froehlich@scai.fraunhofer.de.

Publikováno v: Scientific reports [Sci Rep] 2020 Nov 05; Vol. 10 (1), pp. 19097. Date of Electronic Publication: 2020 Nov 05.

Differences in cohort study data affect external validation of artificial intelligence models for predictive diagnostics of dementia - lessons for translation into clinical practice.

Autor: Birkenbihl C; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, 53757 Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, Rheinische Friedrich-Wilhelms-Universität Bonn, 53115 Bonn, Germany., Emon MA; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, 53757 Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, Rheinische Friedrich-Wilhelms-Universität Bonn, 53115 Bonn, Germany., Vrooman H; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, Netherlands.; Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, Netherlands., Westwood S; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK., Lovestone S; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK., Hofmann-Apitius M; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, 53757 Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, Rheinische Friedrich-Wilhelms-Universität Bonn, 53115 Bonn, Germany., Fröhlich H; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, 53757 Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, Rheinische Friedrich-Wilhelms-Universität Bonn, 53115 Bonn, Germany.; UCB Biosciences GmbH, Alfred-Nobel Str. 10, 40789 Monheim am Rhein, Germany.

Publikováno v: The EPMA journal [EPMA J] 2020 Jun 22; Vol. 11 (3), pp. 367-376. Date of Electronic Publication: 2020 Jun 22 (Print Publication: 2020).

Deep learning for clustering of multivariate clinical patient trajectories with missing values.

Autor: de Jong J; UCB Biosciences GmbH, Alfred-Nobel-Strasse 10, 40789 Monheim, Germany., Emon MA; Fraunhofer Institute for Algorithms and Scientific Computing, Schloss Birlinghoven, Konrad-Adenauer-Strasse, 53754 Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, University of Bonn, Konrad-Adenauer-Strasse, 53115 Bonn, Germany., Wu P; UCB Pharma, Bath Road 216, Slough SL1 3WE, UK., Karki R; Fraunhofer Institute for Algorithms and Scientific Computing, Schloss Birlinghoven, Konrad-Adenauer-Strasse, 53754 Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, University of Bonn, Konrad-Adenauer-Strasse, 53115 Bonn, Germany., Sood M; Fraunhofer Institute for Algorithms and Scientific Computing, Schloss Birlinghoven, Konrad-Adenauer-Strasse, 53754 Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, University of Bonn, Konrad-Adenauer-Strasse, 53115 Bonn, Germany., Godard P; UCB Pharma, Chemin du Foriest 1, 1420 Braine-l'Alleud, Belgium., Ahmad A; Bonn-Aachen International Center for IT, University of Bonn, Konrad-Adenauer-Strasse, 53115 Bonn, Germany., Vrooman H; Erasmus MC, University Medical Center Rotterdam, Department of Radiology, Doctor Molewaterplein 40, PO Box 2040, 3000 CA Rotterdam, Netherlands.; Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, Department of Medical Informatics, PO Box 2040, 3000 CA Rotterdam, Netherlands., Hofmann-Apitius M; Fraunhofer Institute for Algorithms and Scientific Computing, Schloss Birlinghoven, Konrad-Adenauer-Strasse, 53754 Sankt Augustin, Germany.; Bonn-Aachen International Center for IT, University of Bonn, Konrad-Adenauer-Strasse, 53115 Bonn, Germany., Fröhlich H; UCB Biosciences GmbH, Alfred-Nobel-Strasse 10, 40789 Monheim, Germany.; Bonn-Aachen International Center for IT, University of Bonn, Konrad-Adenauer-Strasse, 53115 Bonn, Germany.

Publikováno v: GigaScience [Gigascience] 2019 Nov 01; Vol. 8 (11).

Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment.

Autor: Domingo-Fernández D; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53754, Germany.; Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn-Aachen International Center for IT, Bonn 53113, Germany., Kodamullil AT; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53754, Germany.; Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn-Aachen International Center for IT, Bonn 53113, Germany., Iyappan A; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53754, Germany.; Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn-Aachen International Center for IT, Bonn 53113, Germany., Naz M; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53754, Germany.; Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn-Aachen International Center for IT, Bonn 53113, Germany., Emon MA; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53754, Germany.; Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn-Aachen International Center for IT, Bonn 53113, Germany., Raschka T; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53754, Germany.; Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn-Aachen International Center for IT, Bonn 53113, Germany., Karki R; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53754, Germany.; Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn-Aachen International Center for IT, Bonn 53113, Germany., Springstubbe S; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53754, Germany., Ebeling C; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53754, Germany., Hofmann-Apitius M; Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, Sankt Augustin 53754, Germany.; Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn-Aachen International Center for IT, Bonn 53113, Germany.

Publikováno v: Bioinformatics (Oxford, England) [Bioinformatics] 2017 Nov 15; Vol. 33 (22), pp. 3679-3681.