A blueprint of the topology and mechanics of the human ovary for next-generation bioengineering and diagnosis

Autor: Emna Ouni, Alexis Peaucelle, Kalina T. Haas, Olivier Van Kerk, Marie-Madeleine Dolmans, Timo Tuuri, Marjut Otala, Christiani A. Amorim

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Although the first dissection of the human ovary dates back to the 17th century, its characterization is still limited. Here, the authors have unraveled a unique biophysical and topological phenotype of reproductive-age tissue, bridging biophysics an

Externí odkaz: https://doaj.org/article/1d872d70b474417da0c4e6c53a12ff93

Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility

Autor: Emna Ouni, Valerie Nedbal, Marta Da Pian, Hangbao Cao, Kalina T. Haas, Alexis Peaucelle, Olivier Van Kerk, Gaetan Herinckx, Etienne Marbaix, Marie-Madeleine Dolmans, Timo Tuuri, Marjut Otala, Christiani A. Amorim, Didier Vertommen

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology, Vol. 109, no.-, p. 91-120 (2022)
Matrix biology : journal of the International Society for Matrix Biology, Vol. 109, p. 91-120 (2022)

Our modern era is witnessing an increasing infertility rate worldwide. Although some of the causes can be attributed to our modern lifestyle (e.g., persistent organic pollutants, late pregnancy), our knowledge of the human ovarian tissue has remained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3624e7e679a881758692492bc729333
https://hdl.handle.net/2078.1/268915

A Draft Map of the Human Ovarian Proteome for Tissue Engineering and Clinical Applications

Autor: Christiani Andrade Amorim, Didier Vertommen, Marie-Madeleine Dolmans, Emna Ouni, Maria Costanza Chiti

Publikováno v: Molecular and Cellular Proteomics, Vol. 18, no. S1, p. S159-S173 (2019)
Molecular & Cellular Proteomics : MCP
Molecular & cellular proteomics : MCP, Vol. 18, no.Suppl 1, p. S159-S173 (2019)

Fertility preservation research in women today is increasingly taking advantage of bioengineering techniques to develop new biomimetic materials and solutions to safeguard ovarian cell function and microenvironment in vitro, and in vivo,. However, av

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33aaa468f75b6ab99dd513a65ec513cb
https://doi.org/10.1074/mcp.ra117.000469

Divide-and-Conquer Matrisome Protein (DC-MaP) Strategy: An MS-Friendly Approach to Proteomic Matrisome Characterization

Autor: Christiani Andrade Amorim, Emna Ouni, Marie-Madeleine Dolmans, Sébastien Pyr dit Ruys, Gaëtan Herinckx, Didier Vertommen

Publikováno v: International Journal of Molecular Sciences, Vol. 21, no. 23, p. 9141 [1-23] (2020)
International Journal of Molecular Sciences
Volume 21
Issue 23
International Journal of Molecular Sciences, Vol 21, Iss 9141, p 9141 (2020)

Currently, the extracellular matrix (ECM) is considered a pivotal complex meshwork of macromolecules playing a plethora of biomolecular functions in health and disease beyond its commonly known mechanical role. Only by unraveling its composition can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca9d28961d08cae985248efc4321314
https://hdl.handle.net/2078.1/240812

The Human Ovary and Future of Fertility Assessment in the Post-Genome Era

Autor: Emna Ouni, Christiani Andrade Amorim, Didier Vertommen

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol. 20, no.17, p. 4209 (2019)
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4209 (2019)

Proteomics has opened up new avenues in the field of gynecology in the post-genome era, making it possible to meet patient needs more effectively and improve their care. This mini-review aims to reveal the scope of proteomic applications through an o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51599e10ea80df78f6b33996d8de6ee3
http://europepmc.org/articles/PMC6747278