Encapsulation of (E)-N’-(1-(7-(diethylamino)-2-oxo-2H-chromen-3 yl)ethylidene)benzohydrazide (7-diEAHC) in β-cyclodextrins: Optimized synthesis of 7-diEACH and in silico ADME profiling, physical stability, antioxidant properties of encapsulated 7-diEAHC and bioavailability in rats

Autor: Emna Khdhiri, Souhir Abid, Khaled Athmouni, Majdi Abid, Habib Ayadi, Houcine Ammar, Ludovic Paquin, Jean-Pierre Bazureau

Publikováno v: Results in Chemistry, Vol 5, Iss , Pp 100681- (2023)

The β-cyclodextrins (β-CD) as supramolecular have extremely attractive pharmaceutical applications. This study focused on the effects of macrocyclic systems complexation on stability, antioxidant activities, and bioavailability of the optimized syn

Externí odkaz: https://doaj.org/article/ac55971b31874eb4b860d1788a2c75c1

(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

Autor: Raouf Hajji, Souhir Abid, Afoua Elmufti, Emna Khdhiri, Houcine Ammar, Lakhdar Ghazouani, Noureddine Allouche, Nizar Tlili, Meriam Tir, Anouar Feriani, Kais Mnafgui

Publikováno v: Oxidative Medicine and Cellular Longevity. 2020:1-15

The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7c06469c87a78d9f1ae4c450a9146f5
https://doi.org/10.1155/2020/2432918

Cardioprotective effects of (E)-4-hydroxy-N′-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide: a newly synthesized coumarin hydrazone against isoproterenol-induced myocardial infarction in a rat model

Autor: Souhir Abid, Kais Mnafgui, Raouf Hajji, Houcine Ammar, Emna Khdhiri, Anouar Feriani, Meriam Tir, Intissar Baaziz, Afoua Elmufti, Hedi Ben Mansour, Lakhdar Ghazouani

Publikováno v: Canadian Journal of Physiology and Pharmacology. 97:989-998

The current study was carried out to evaluate the effect of pretreatment and co-treatment with a newly synthesized coumarin hydrazone, (E)-4-hydroxy-N′-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide (hereinafter EK6), against isoproter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c5af3c3997fc69b0609e0babc05b43e
https://doi.org/10.1139/cjpp-2019-0085

Cardiopreventive capacity of a novel (E)-N'-(1-(7-methoxy-2-oxo-2H-chromen-3-yl) ethylidene)-4-methylbenzenesulfonohydrazide against isoproterenol-induced myocardial infarction by moderating biochemical, oxidative stress, and histological parameters

Autor: Houcine Ammar, Kamel Jamoussi, Majdi Abid, Raouf Hajji, Emna Khdhiri, Noureddine Allouche, Anouar Feriani, Lakhdar Ghazouani, Marwa Ncir, Kais Mnafgui, Dana Jallouli, Souhir Abid

Publikováno v: Journal of biochemical and molecular toxicologyREFERENCES. 35(6)

This study is carried out to assess the cardiopreventive effect of (E)-N'-(1-(7-methoxy-2-oxo-2H-chromen-3-yl) ethylidene)-4-methylbenzenesulfonohydrazide or SHC, a novel synthesized coumarin, against myocardial infarction induced by isoproterenol (I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17350c31901393e57d33ca706d9bbec
https://pubmed.ncbi.nlm.nih.gov/33624406

(E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide protecting rat heart tissues from isoproterenol toxicity: Evidence from in vitro and in vivo tests

Autor: Emna Khdhiri, Jean Pierre Bazureau, Lakhdar Ghazouani, Noureddine Allouche, Souhir Abid, Houcine Ammar, Raouf Hajji, Walid Bouzanna, Anouar Feriani, Kais Mnafgui

Publikováno v: European Journal of Pharmacology
European Journal of Pharmacology, Elsevier, 2020, 881, pp.173137. ⟨10.1016/j.ejphar.2020.173137⟩
European Journal of Pharmacology, 2020, 881, pp.173137. ⟨10.1016/j.ejphar.2020.173137⟩

International audience; The current study was aimed to assess the protective effect of a new molecule (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c, against cardiac remodeling process in isoproterenol (Isop) induced m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df5f471699877dd072485317b09faf3
https://pubmed.ncbi.nlm.nih.gov/32380016