Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Emna Harigua‐Souiai"'
Autor:
Emna Harigua-Souiai, Ons Masmoudi, Samer Makni, Rafeh Oualha, Yosser Z. Abdelkrim, Sara Hamdi, Oussama Souiai, Ikram Guizani
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Computer-aided drug discovery (CADD) is nurtured by late advances in big data analytics and Artificial Intelligence (AI) towards enhanced drug discovery (DD) outcomes. In this context, reliable datasets are of utmost importance. We herein pr
Externí odkaz:
https://doaj.org/article/9ff8ec457dbc46079f85d76fcbe61c77
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Drug repurposing is a promising approach towards the discovery of novel treatments against Neglected Tropical Diseases, such as Leishmaniases, presenting the advantage of reducing both costs and duration of the drug discovery process. In previous wor
Externí odkaz:
https://doaj.org/article/306d9dbeb6ee4b7ca8fd1aa212a7f481
Autor:
Oussema Souiai, Marwa Arbi, Mariem Hanachi, Ameny Sallami, Imen Larbi, Melek Chaouch, Emna Harigua-Souiai, Alia Benkahla
Publikováno v:
Evolutionary Bioinformatics, Vol 19 (2023)
Bluetongue virus (BTV) is an arbovirus considered as a major threat for the global livestock economy. Since 1999, Tunisia has experienced several incursions of BTV, during which numerous cases of infection and mortality have been reported. However, t
Externí odkaz:
https://doaj.org/article/d869bcfcb4a541ad8115bc510f3d4805
Autor:
Mariem Ben Rekaya, Feryel Ksontini, Linda Bel Haj Kacem, Farah Sassi, Emna Harigua‐Souiai, Ryma Boujneh, Ahmed H'mayada, Yosra Zaimi, Mouna Ayadi, Mediha Trabelsi, Ridha Mrad, Soumaya Rammeh
Publikováno v:
Clinical Case Reports, Vol 11, Iss 6, Pp n/a-n/a (2023)
Key clinical message We report the first case of pathologic complete response (pCR) to neoadjuvant imatinib in a gastric stromal tumor harboring KIT mutations in both exons 11 and 9. The significance of this co‐occurrence is unknown and might incre
Externí odkaz:
https://doaj.org/article/348465859f9f47bca3a3dbc9997dbcd1
Publikováno v:
Bioinformatics and Biology Insights, Vol 16 (2022)
Drug discovery (DD) research is a complex field with a high attrition rate. Machine learning (ML) approaches combined to chemoinformatics are of valuable input to this field. We, herein, focused on implementing multiple ML algorithms that shall learn
Externí odkaz:
https://doaj.org/article/eed0f3c2eb6e478fa3a9e40485d10519
Autor:
Mariem Hanachi, Olfa Maghrebi, Haifa Bichiou, Ferdaous Trabelsi, Najla Maha Bouyahia, Fethi Zhioua, Meriam Belghith, Emna Harigua-Souiai, Meriem Baouendi, Lamia Guizani-Tabbane, Alia Benkahla, Oussema Souiai
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Microbiota colonization is a dynamic process that impacts the health status during an individual's lifetime. The composition of the gut microbiota of newborns is conditioned by multiple factors, including the delivery mode (DM). Nonetheless, the DM's
Externí odkaz:
https://doaj.org/article/45dfb4d4e037435aa777190ddad13d3f
Autor:
Emna Harigua-Souiai, Mohamed Mahmoud Heinhane, Yosser Zina Abdelkrim, Oussama Souiai, Ines Abdeljaoued-Tej, Ikram Guizani
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Drug discovery and repurposing against COVID-19 is a highly relevant topic with huge efforts dedicated to delivering novel therapeutics targeting SARS-CoV-2. In this context, computer-aided drug discovery is of interest in orienting the early high th
Externí odkaz:
https://doaj.org/article/7bc2c5a443dc4da8b6177a50cec908ee
Autor:
Insaf Bel Hadj Ali, Hamed Chouaieb, Yusr Saadi Ben Aoun, Emna Harigua-Souiai, Hejer Souguir, Alia Yaacoub, Oussaïma El Dbouni, Zoubir Harrat, Maowia M Mukhtar, Moncef Ben Said, Nabil Haddad, Akila Fathallah-Mili, Ikram Guizani
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009530 (2021)
BackgroundDipeptidyl peptidase III (DPPIII) member of M49 peptidase family is a zinc-dependent metallopeptidase that cleaves dipeptides sequentially from the N-terminus of its substrates. In Leishmania, DPPIII, was reported with other peptidases to p
Externí odkaz:
https://doaj.org/article/3f51e8a49a2c4c47bbf6a839aaee125f
Autor:
Yosser Zina Abdelkrim, Emna Harigua-Souiai, Imen Bassoumi-Jamoussi, Mourad Barhoumi, Josette Banroques, Khadija Essafi-Benkhadir, Michael Nilges, Arnaud Blondel, N. Kyle Tanner, Ikram Guizani
Publikováno v:
Molecules, Vol 27, Iss 18, p 5890 (2022)
Previous investigations of the Leishmania infantum eIF4A-like protein (LieIF4A) as a potential drug target delivered cholestanol derivatives inhibitors. Here, we investigated the mode of action of cholesterol derivatives as a novel scaffold structure
Externí odkaz:
https://doaj.org/article/dd3b2dc394d34a8a8f9fc27de5aab333
Autor:
Mariem Hanachi, Anmol Kiran, Jennifer Cornick, Emna Harigua-Souiai, Dean Everett, Alia Benkahla, Oussama Souiai
Publikováno v:
Bioinformatics and Biology Insights, Vol 14 (2020)
Streptococcus pneumoniae serotype 1 is a common cause of global invasive pneumococcal disease. In New Caledonia, serotype 1 is the most prevalent serotype and led to two major outbreaks reported in the 2000s. The pneumococcal conjugate vaccine 13 (PC
Externí odkaz:
https://doaj.org/article/1718fbc8a69f4c5ba2f680108c76eb4e