Loss of DJ-1 protein stability and cytoprotective function by Parkinson's disease-associated proline-158 deletion

Autor: Karina Fog, Emmy Helena Rannikko, Philipp J. Kahle, Stephanie Weber, Louise Buur Vesterager, Poul Henning Jensen, Jafar H. A. Shaik, Elena M. Cornejo Castro

Publikováno v: Journal of neurochemistry 125(2), 314-327 (2013). doi:10.1111/jnc.12126
Journal of Neurochemistry; Vol 125
Rainnikko, E H, Vesterager, L B, Shaik, J H A, Stephanie S., W, Cornejo Castro, E M, Fog, K, Jensen, P H & Kahle, P J 2013, ' Loss of DJ-1 protein stability and cytoprotective function by Parkinson’s disease-associated proline-158 deletion ', Journal of Neurochemistry, vol. 10.1111 . https://doi.org/10.1111/jnc.12126
Journal of Neurochemistry

DJ-1 is a ubiquitous protein regulating cellular viability. Recessive mutations in the PARK7/DJ-1 gene are linked to Parkinson's disease (PD). Although the most dramatic L166P point mutation practically eliminates DJ-1 protein and function, the effec

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https://pub.dzne.de/record/136869