Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Emmie, de Wit"'
Autor:
Manmeet Singh, Kerry Goldin, Meaghan Flagg, Brandi N Williamson, Tessa Lutterman, Brian Smith, Emmie de Wit
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 10, p e0012635 (2024)
Nipah virus (NiV) is a highly pathogenic Paramyxovirus associated with outbreaks in Malaysia, Bangladesh, and India with high mortality rates. NiV infection causes fatal respiratory and neurological disease. The majority of survivors suffer from long
Externí odkaz:
https://doaj.org/article/c3716eecc7bb484c80dee558076243cd
Autor:
Meaghan Flagg, Kerry Goldin, Lizzette Pérez-Pérez, Manmeet Singh, Brandi N. Williamson, Nathanael Pruett, Chuong D. Hoang, Emmie de Wit
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
There is tremendous heterogeneity in the severity of COVID-19 disease in the human population, and the mechanisms governing the development of severe disease remain incompletely understood. The emergence of SARS-CoV-2 variants of concern (VOC) Delta
Externí odkaz:
https://doaj.org/article/ec540c177e954033983095d97fb37a3b
Autor:
Neeltje van Doremalen, Victoria A. Avanzato, Kerry Goldin, Friederike Feldmann, Jonathan E. Schulz, Elaine Haddock, Atsushi Okumura, Jamie Lovaglio, Patrick W. Hanley, Kathleen Cordova, Greg Saturday, Emmie de Wit, Teresa Lambe, Sarah C. Gilbert, Vincent J. Munster
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Nipah virus (NiV) is a highly pathogenic and re-emerging virus, which causes sporadic but severe infections in humans. Currently, no vaccines against NiV have been approved. We previously showed that ChAdOx1 NiV provides full protection agai
Externí odkaz:
https://doaj.org/article/83a42009c7d8459eafa1e723eb0e5001
Autor:
Emmie de Wit, Friederike Feldmann, Jacqueline Cronin, Kerry Goldin, Reinaldo Mercado-Hernandez, Brandi N. Williamson, Kimberly Meade-White, Atsushi Okumura, Julie Callison, Sarah Weatherman, Rebecca Rosenke, Victoria A. Avanzato, Jamie Lovaglio, Dana P. Scott, Andrea Marzi, Heinz Feldmann
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104405- (2023)
Summary: Background: Nipah virus (NiV) causes recurrent outbreaks of lethal respiratory and neurological disease in Southeast Asia. The World Health Organization considers the development of an effective vaccine against NiV a priority. Methods: We pr
Externí odkaz:
https://doaj.org/article/dfff7aaf39d542d6855906a23c3664cd
Autor:
Robert J. Fischer, Neeltje van Doremalen, Danielle R. Adney, Claude Kwe Yinda, Julia R. Port, Myndi G. Holbrook, Jonathan E. Schulz, Brandi N. Williamson, Tina Thomas, Kent Barbian, Sarah L. Anzick, Stacy Ricklefs, Brian J. Smith, Dan Long, Craig Martens, Greg Saturday, Emmie de Wit, Sarah C. Gilbert, Teresa Lambe, Vincent J. Munster
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Emerging SARS-CoV-2 variants raise concerns about vaccine effectiveness. Here, the authors show that the ChAdOx1 nCoV-19 (AZD1222) vaccine protects Syrian hamsters from pulmonary infection and disease after infection with SARS-CoV-2 B.1.351 or B.1.1.
Externí odkaz:
https://doaj.org/article/cd521c32186f4059b6298768dcc0d51a
Autor:
Claude Kwe Yinda, Julia R. Port, Trenton Bushmaker, Robert J. Fischer, Jonathan E. Schulz, Myndi G. Holbrook, Carl Shaia, Emmie de Wit, Neeltje van Doremalen, Vincent J. Munster
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1284-1292 (2021)
The circulation of SARS-CoV-2 has resulted in the emergence of variants of concern (VOCs). It is currently unclear whether the previous infection with SARS-CoV-2 provides protection against reinfection with VOCs. Here, we show that low dose aerosol e
Externí odkaz:
https://doaj.org/article/dcdd4e3a1c48432d81ca858457a3e490
Autor:
César Muñoz-Fontela, Lina Widerspick, Randy A Albrecht, Martin Beer, Miles W Carroll, Emmie de Wit, Michael S Diamond, William E Dowling, Simon G P Funnell, Adolfo García-Sastre, Nora M Gerhards, Rineke de Jong, Vincent J Munster, Johan Neyts, Stanley Perlman, Douglas S Reed, Juergen A Richt, Ximena Riveros-Balta, Chad J Roy, Francisco J Salguero, Michael Schotsaert, Lauren M Schwartz, Robert A Seder, Joaquim Segalés, Seshadri S Vasan, Ana María Henao-Restrepo, Dan H Barouch
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010161 (2022)
The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to
Externí odkaz:
https://doaj.org/article/2e0188b1403e45f2bd75009acab0b6c7
Autor:
Robert J. Fischer, Dylan H. Morris, Neeltje van Doremalen, Shanda Sarchette, M. Jeremiah Matson, Trenton Bushmaker, Claude Kwe Yinda, Stephanie N. Seifert, Amandine Gamble, Brandi N. Williamson, Seth D. Judson, Emmie de Wit, James O. Lloyd-Smith, Vincent J. Munster
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 9, Pp 2253-2255 (2020)
The coronavirus pandemic has created worldwide shortages of N95 respirators. We analyzed 4 decontamination methods for effectiveness in deactivating severe acute respiratory syndrome coronavirus 2 virus and effect on respirator function. Our results
Externí odkaz:
https://doaj.org/article/0f3a76f2a68942b09df6897d345cbc9c
Autor:
Claude Kwe Yinda, Julia R Port, Trenton Bushmaker, Irene Offei Owusu, Jyothi N Purushotham, Victoria A Avanzato, Robert J Fischer, Jonathan E Schulz, Myndi G Holbrook, Madison J Hebner, Rebecca Rosenke, Tina Thomas, Andrea Marzi, Sonja M Best, Emmie de Wit, Carl Shaia, Neeltje van Doremalen, Vincent J Munster
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009195 (2021)
SARS-CoV-2 emerged in late 2019 and resulted in the ongoing COVID-19 pandemic. Several animal models have been rapidly developed that recapitulate the asymptomatic to moderate disease spectrum. Now, there is a direct need for additional small animal
Externí odkaz:
https://doaj.org/article/798ae271b60d4475a045eac12954dcfe
Autor:
Kyle Rosenke, Michael A. Jarvis, Friederike Feldmann, Benjamin Schwarz, Atsushi Okumura, Jamie Lovaglio, Greg Saturday, Patrick W. Hanley, Kimberly Meade-White, Brandi N. Williamson, Frederick Hansen, Lizette Perez-Perez, Shanna Leventhal, Tsing-Lee Tang-Huau, Julie Callison, Elaine Haddock, Kaitlin A. Stromberg, Dana Scott, Graham Sewell, Catharine M. Bosio, David Hawman, Emmie de Wit, Heinz Feldmann
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human COVID-19 clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies to help guide decisions. Her
Externí odkaz:
https://doaj.org/article/28b738a56bae42afa6e041613cef0ac9