Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Emmi Helle"'
Autor:
Martin Broberg, Minna Ampuja, Samuel Jones, Tiina Ojala, Otto Rahkonen, Riikka Kivelä, James Priest, FinnGen, Aarno Palotie, Hanna M. Ollila, Emmi Helle
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Congenital heart defects (CHD) are structural defects of the heart affecting approximately 1% of newborns. They exhibit low penetrance and non-Mendelian patterns of inheritance as varied and complex traits. While genetic factors a
Externí odkaz:
https://doaj.org/article/c8b8a945cab44e5eba3e205c0ac94c08
Autor:
Elizabeth E. Blue, Janson J. White, Michael K. Dush, William W. Gordon, Brent H. Wyatt, Peter White, Colby T. Marvin, Emmi Helle, Tiina Ojala, James R. Priest, Mary M. Jenkins, Lynn M. Almli, Jennita Reefhuis, Faith Pangilinan, Lawrence C. Brody, Kim L. McBride, Vidu Garg, Gary M. Shaw, Paul A. Romitti, Wendy N. Nembhard, Marilyn L. Browne, Martha M. Werler, Denise M. Kay, Seema Mital, Jessica X. Chong, Nanette M. Nascone-Yoder, Michael J. Bamshad
Publikováno v:
HGG Advances, Vol 4, Iss 4, Pp 100232- (2023)
Summary: Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect (CHD) characterized by hypoplasia of the left ventricle and aorta along with stenosis or atresia of the aortic and mitral valves. HLHS represents only ∼4%–8% of a
Externí odkaz:
https://doaj.org/article/02c4caf366fb4060935dbf5c314b1e69
Autor:
Maria Hurskainen, Ivana Mižíková, David P. Cook, Noora Andersson, Chanèle Cyr-Depauw, Flore Lesage, Emmi Helle, Laurent Renesme, Robert P. Jankov, Markku Heikinheimo, Barbara C. Vanderhyden, Bernard Thébaud
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially
Externí odkaz:
https://doaj.org/article/f32cc8aebe874074a51d470766b32ce0
Autor:
Emmi Helle, Minna Ampuja, Alexandra Dainis, Laura Antola, Elina Temmes, Erik Tolvanen, Eero Mervaala, Riikka Kivelä
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cell-cell interactions are crucial for organ development and function. In the heart, endothelial cells engage in bidirectional communication with cardiomyocytes regulating cardiac development and growth. We aimed to elucidate the organotypic developm
Externí odkaz:
https://doaj.org/article/3791680514c546ae8bc919751bd05982
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The vascular system is essential for the development and function of all organs and tissues in our body. The molecular signature and phenotype of endothelial cells (EC) are greatly affected by blood flow-induced shear stress, which is a vital compone
Externí odkaz:
https://doaj.org/article/90b8434cca9b43128ab997ad4395bbe9
Autor:
Emmi Helle, Jaana Pihkala, Riitta Turunen, Hanna Ruotsalainen, Sari Tuupanen, Juha Koskenvuo, Tiina Ojala
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
Myocardial dysfunction is a known risk factor for morbidity and mortality in hypoplastic left heart syndrome (HLHS). Variants in some transcription factor and contractility genes, which are known to cause cardiomyopathy, have previously been associat
Externí odkaz:
https://doaj.org/article/52358e81a3284a9cb44689f66c7d40ee
Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring
Autor:
Emmi Helle, James R. Priest
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 8 (2020)
Abstract Congenital heart disease (CHD) is the most common anatomical malformation occurring live‐born infants and an increasing cause of morbidity and mortality across the lifespan and throughout the world. Population‐based observations have lon
Externí odkaz:
https://doaj.org/article/52b5f76263c94b539c8e767233206365
Publikováno v:
Genes, Vol 12, Iss 6, p 921 (2021)
Congenital heart defects (CHD) are developmental malformations affecting the heart and the great vessels. Early heart development requires temporally regulated crosstalk between multiple cell types, signaling pathways, and mechanical forces of early
Externí odkaz:
https://doaj.org/article/b61650c055444b15b1c9379b398158f7
Autor:
Anu Kaskinen, Emmi Helle
Publikováno v:
European Heart Journal. 44:1293-1295
Autor:
Johanna Huida, Tiina Ojala, Johanna Ilvesvuo, Heljä‐Marja Surcel, James R. Priest, Emmi Helle
Background: Higher maternal body mass index (BMI) and abnormal glucose metabolism during early pregnancy are associated with congenital heart defects in the offspring, but the exact mechanisms are unknown.Methods: We evaluated the association between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c1f894522617a7daaae6e7bc920af2
http://hdl.handle.net/10138/355667
http://hdl.handle.net/10138/355667