Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Emmi, Kokki"'
Publikováno v:
Frontiers in Drug Delivery, Vol 3 (2023)
Introduction: The eye is an excellent target for gene therapy because of its anatomical features. Gene therapy to treat ocular disorders relies on efficient gene delivery and transgene expression in the target cells. The aim of this study was to comp
Externí odkaz:
https://doaj.org/article/1dc344c761d7463193491f7f70b3ca99
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 219 (2021)
Pathological vessel growth harms vision and may finally lead to vision loss. Anti-angiogenic gene therapy with viral vectors for ocular neovascularization has shown great promise in preclinical studies. Most of the studies have been conducted with di
Externí odkaz:
https://doaj.org/article/9fcb385b4ed746a3adc7fe558447ba58
Autor:
Jooseppi, Puranen, Sanna, Koponen, Tiina, Nieminen, Iiris, Kanerva, Emmi, Kokki, Pyry, Toivanen, Arto, Urtti, Seppo, Ylä-Herttuala, Marika, Ruponen
Pathological angiogenesis related to neovascularization in the eye is mediated through vascular endothelial growth factors (VEGFs) and their receptors. Ocular neovascular-related diseases are mainly treated with anti-VEGF agents. In this study we eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe228f364b41fb63a4fb7b48c3599cf7
http://hdl.handle.net/10138/350462
http://hdl.handle.net/10138/350462
Pathological vessel growth harms vision and may finally lead to vision loss. Anti-angiogenic gene therapy with viral vectors for ocular neovascularization has shown great promise in preclinical studies. Most of the studies have been conducted with di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d45617553e8d508bed0176ddb78722
https://doi.org/10.20944/preprints202012.0602.v1
https://doi.org/10.20944/preprints202012.0602.v1
Autor:
Guido R.Y. De Meyer, Sanna Kettunen, Emmi Kokki, Tommi Karttunen, Seppo Ylä-Herttuala, Kati Kinnunen
Publikováno v:
Current trends in ophthalmology
Aim: Transgenic mice with an elastic fiber mutation (C1039G+/-) in the fibrillin-1 gene and apolipoprotein E deficiency express vulnerable atherosclerotic plaque formation in the aorta and coronary and carotid arteries. The fibrillin-1 gene mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbf1f13a64ee2883607fec36ce8ea00
https://doi.org/10.18314/ctoy.v1i1.1265
https://doi.org/10.18314/ctoy.v1i1.1265
Publikováno v:
Genes
Vascular endothelial growth factor (VEGF) expression induces age-related macular degeneration (AMD), which is a common vision-threatening disease due to choroidal neovascularization and a fibrovascular membrane. We describe a mouse model of neovascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0d7aac1aea876ebc97733ad5838d0d6
https://pubmed.ncbi.nlm.nih.gov/30200369
https://pubmed.ncbi.nlm.nih.gov/30200369
Autor:
Kari J. Airenne, Hannu Uusitalo, Hanna P. Lesch, Laura Alasaarela, Kati Kinnunen, T. Tuulos, Emmi Kokki, Giedrius Kalesnykas, Seppo Ylä-Herttuala
Publikováno v:
Current Gene Therapy. 17
Background The eye possesses unique anatomical features that make it a valuable target for gene therapy applications. Objective The aim of the current study was to compare transduction efficiency, safety and biodistribution of four viral vectors foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb4be93a06d4494a1ad6d38d45d011b
https://doi.org/10.2174/1566523217666171003170348
https://doi.org/10.2174/1566523217666171003170348
Publikováno v:
Genes
Volume 9
Issue 9
Genes, Vol 9, Iss 9, p 438 (2018)
Volume 9
Issue 9
Genes, Vol 9, Iss 9, p 438 (2018)
Vascular endothelial growth factor (VEGF) expression induces age-related macular degeneration (AMD), which is a common vision-threatening disease due to choroidal neovascularization and a fibrovascular membrane. We describe a mouse model of neovascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e13598643b56b554e177fd77587b5a
https://doi.org/10.3390/genes9090438
https://doi.org/10.3390/genes9090438
Autor:
Jonna K. Koponen, Hanna Sallinen, Seppo Ylä-Herttuala, Maarit Anttila, Kirsi Hämäläinen, Kari Alitalo, Seppo Heinonen, Pyry I. Toivanen, Veli-Matti Kosma, Laura Tuppurainen, Emmi Kokki, Kati Pulkkinen, Tommi Heikura
Publikováno v:
Human gene therapy. Clinical development. 24(1)
Antiangiogenic and antilymphangiogenic gene therapy with soluble vascular endothelial growth factor receptor-2 (VEGFR-2) and soluble VEGFR-3 in combination with chemotherapy is a potential new treatment for ovarian carcinoma. We evaluated the safety,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2588fb98d82a8e284785266496cecfc4
https://pubmed.ncbi.nlm.nih.gov/23692381
https://pubmed.ncbi.nlm.nih.gov/23692381