Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Emmett M. Leddin"'
Autor:
Maria Guillamot, Iannis Aifantis, Ann-Kathrin Eisfeld, Aristotelis Tsirigos, G. Andrés Cisneros, Rahul M. Kohli, Olga A. Guryanova, John C. Byrd, Richard M. Stone, Aaron D Viny, Omar Abdel-Wahab, Eric Wang, Daniel T Starczynowski, Varvara Paraskevopoulou, Kate Corrigan, Jingjing Wang, Deedra Nicolet, Hedieh Torabifard, Christian E. Loo, Emmett M. Leddin, Igor Dolgalev, Sanam Loghavi, Geraldine Cayanan, Anna Yeaton
Supplementary Figure from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05afc7f9aecb6daf84e01d275ffa047f
https://doi.org/10.1158/2159-8290.22541788
https://doi.org/10.1158/2159-8290.22541788
Autor:
Maria Guillamot, Iannis Aifantis, Ann-Kathrin Eisfeld, Aristotelis Tsirigos, G. Andrés Cisneros, Rahul M. Kohli, Olga A. Guryanova, John C. Byrd, Richard M. Stone, Aaron D Viny, Omar Abdel-Wahab, Eric Wang, Daniel T Starczynowski, Varvara Paraskevopoulou, Kate Corrigan, Jingjing Wang, Deedra Nicolet, Hedieh Torabifard, Christian E. Loo, Emmett M. Leddin, Igor Dolgalev, Sanam Loghavi, Geraldine Cayanan, Anna Yeaton
Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of mutated preleukemic cells. Individuals with CH are at an increased risk of developing hematopoietic malignancies. Here, we describe a novel animal mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111d96e591346027bae11a73a9d2677e
https://doi.org/10.1158/2159-8290.c.6549742.v1
https://doi.org/10.1158/2159-8290.c.6549742.v1
Autor:
Maria Guillamot, Iannis Aifantis, Ann-Kathrin Eisfeld, Aristotelis Tsirigos, G. Andrés Cisneros, Rahul M. Kohli, Olga A. Guryanova, John C. Byrd, Richard M. Stone, Aaron D Viny, Omar Abdel-Wahab, Eric Wang, Daniel T Starczynowski, Varvara Paraskevopoulou, Kate Corrigan, Jingjing Wang, Deedra Nicolet, Hedieh Torabifard, Christian E. Loo, Emmett M. Leddin, Igor Dolgalev, Sanam Loghavi, Geraldine Cayanan, Anna Yeaton
Supplementary Data from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093378146ee920511199c20be1d29d73
https://doi.org/10.1158/2159-8290.22541791
https://doi.org/10.1158/2159-8290.22541791
Publikováno v:
J Chem Theory Comput
Selection of residues and other molecular fragments for inclusion in the quantum mechanics (QM) region for QM/molecular mechanics (MM) simulations is an important step for these calculations. Here, we present an approach that combines protein sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f565746d7eef3d54630d8a0ed0fe466
https://doi.org/10.1021/acs.jctc.1c00313
https://doi.org/10.1021/acs.jctc.1c00313
Autor:
Irving, Simonin-Wilmer, Raul, Ossio, Emmett M, Leddin, Mark, Harland, Karen A, Pooley, Mauricio Gerardo, Martil de la Garza, Sofia, Obolenski, James, Hewinson, Chi C, Wong, Vivek, Iyer, John C, Taylor, Julia A, Newton-Bishop, D Timothy, Bishop, Gerardo Andrés, Cisneros, Mark M, Iles, David J, Adams, Carla Daniela, Robles-Espinoza
Publikováno v:
Journal of medical genetics.
Pathogenic germline variants in the protection of telomeres 1 gene (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64c3cf9fc9ad536181698f23c89b8e0c
https://pubmed.ncbi.nlm.nih.gov/36539277
https://pubmed.ncbi.nlm.nih.gov/36539277
Publikováno v:
J Chem Inf Model
Remdesivir was the first antiviral drug that received emergency use authorization from the United States Food and Drug Administration and is now formally approved to treat COVID-19. Remdesivir is a nucleotide analogue that targets the RNA-dependent R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6834b6124eb69bdded5c588f2715cd
https://doi.org/10.26434/chemrxiv-2022-4s2c7-v2
https://doi.org/10.26434/chemrxiv-2022-4s2c7-v2
Publikováno v:
Biophysical journal. 121(19)
The prediction of protein mutations that affect function may be exploited for multiple uses. In the context of disease variants, the prediction of compensatory mutations that reestablish functional phenotypes could aid in the development of genetic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e78100436f1301f38dd38cf1cafe65
https://pubmed.ncbi.nlm.nih.gov/35642254
https://pubmed.ncbi.nlm.nih.gov/35642254
Autor:
Irving Simonin-Wilmer, Raul Ossio, Emmett M Leddin, Mark Harland, Karen A Pooley, Mauricio Gerardo Martil de la Garza, Sofia Obolenski, James Hewinson, Chi C Wong, Vivek Iyer, John C Taylor, Julia A Newton-Bishop, D Timothy Bishop, Gerardo Andrés Cisneros, Mark M Iles, David J Adams, Carla Daniela Robles-Espinoza
Publikováno v:
Journal of Medical Genetics. :jmg-2022
Pathogenic germline variants in the protection of telomeres 1 gene (POT1) have been associated with predisposition to a range of tumour types, including melanoma, glioma, leukaemia and cardiac angiosarcoma. We sequenced all coding exons of thePOT1gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14fd9afb66194c20848f9ab259928db7
https://doi.org/10.1136/jmg-2022-108776
https://doi.org/10.1136/jmg-2022-108776
Autor:
Anna Yeaton, Geraldine Cayanan, Sanam Loghavi, Igor Dolgalev, Emmett M. Leddin, Christian E. Loo, Hedieh Torabifard, Deedra Nicolet, Jingjing Wang, Kate Corrigan, Varvara Paraskevopoulou, Daniel T Starczynowski, Eric Wang, Omar Abdel-Wahab, Aaron D Viny, Richard M. Stone, John C. Byrd, Olga A. Guryanova, Rahul M. Kohli, G. Andrés Cisneros, Aristotelis Tsirigos, Ann-Kathrin Eisfeld, Iannis Aifantis, Maria Guillamot
Publikováno v:
Cancer discovery. 12(10)
Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of mutated preleukemic cells. Individuals with CH are at an increased risk of developing hematopoietic malignancies. Here, we describe a novel animal mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5060b7189b2696b2c864bcd8c5b666b3
https://pubmed.ncbi.nlm.nih.gov/36196576
https://pubmed.ncbi.nlm.nih.gov/36196576
We present an approach that combines protein sequence/structure evolution and electron localization function (ELF) analyses. The combination of these two analysis allows the determination of whether a residue needs to be included in the QM subsystem,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588ca9006b8085a2a1f01701d0c49123
https://doi.org/10.26434/chemrxiv.14343137.v1
https://doi.org/10.26434/chemrxiv.14343137.v1