Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Emmett, Fitzpatrick"'
Autor:
Thomas Clark, Vidya Subramanian, Akila Jayaraman, Emmett Fitzpatrick, Ranjani Gopal, Niharika Pentakota, Troy Rurak, Shweta Anand, Alexander Viglione, Rahul Raman, Kannan Tharakaraman, Ram Sasisekharan
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract The application of machine learning (ML) models to optimize antibody affinity to an antigen is gaining prominence. Unfortunately, the small and biased nature of the publicly available antibody-antigen interaction datasets makes it challengin
Externí odkaz:
https://doaj.org/article/1dbbc8d07dad4d94bd9af58c95b39d1f
Autor:
Ranjani Gopal, Emmett Fitzpatrick, Niharika Pentakota, Akila Jayaraman, Kannan Tharakaraman, Ishan Capila
Publikováno v:
Viruses, Vol 14, Iss 12, p 2694 (2022)
The computational methods used for engineering antibodies for clinical development have undergone a transformation from three-dimensional structure-guided approaches to artificial-intelligence- and machine-learning-based approaches that leverage the
Externí odkaz:
https://doaj.org/article/785e6697f17a4990ad754227df2dff8c
Autor:
Estibaliz Castillero, Emmett Fitzpatrick, Samuel J. Keeney, Alex M. D’Angelo, Benjamin B. Pressly, Michael T. Simpson, Mangesh Kurade, W. Clinton Erwin, Vivian Moreno, Chiara Camillo, Halley J. Shukla, Vaishali V. Inamdar, Arbi Aghali, Juan B. Grau, Elisa Salvati, Itzhak Nissim, Lubica Rauova, Mark A. Oyama, Stanley J. Stachelek, Chase Brown, Abba M. Krieger, Robert J. Levy, Giovanni Ferrari
Publikováno v:
Sci Transl Med
Degenerative mitral valve (MV) regurgitation (MR) is a highly prevalent heart disease that requires surgery in severe cases. Here, we show that a decrease in the activity of the serotonin transporter (SERT) accelerates MV remodeling and progression t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b905f7779efd561ae31c4dfab90771f
https://europepmc.org/articles/PMC9896655/
https://europepmc.org/articles/PMC9896655/
Autor:
Vaishali Inamdar, Menekhem Zviman, George Bratinov, Emmett Fitzpatrick, Kristin Gardiner, Robert Levy, Stanley J Stachelek, Ilia Fishbein
Publikováno v:
Circulation. 144
Background: Inflammatory mechanisms, which can be affected by altered metabolic profiles such as hypercholesterolemia (HC), contribute to the pathophysiology of in-stent restenosis (ISR). CD47 is a transmembrane protein that is known to inhibit immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7176b33e84616d5b96be9ff208836ed4
https://doi.org/10.1161/circ.144.suppl_1.11439
https://doi.org/10.1161/circ.144.suppl_1.11439
Autor:
Robert J. Levy, Ivan S. Alferiev, Emmett Fitzpatrick, Stanley J. Stachelek, Vaishali V. Inamdar, Ilia Fishbein
Publikováno v:
J Vis Exp
The key complications associated with bare metal stents and drug eluting stents are in-stent restenosis and late stent thrombosis, respectively. Thus, improving the biocompatibility of metal stents remains a significant challenge. The goal of this pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2252fb9dd5505df392d93aab2ef36d
https://doi.org/10.3791/61545
https://doi.org/10.3791/61545
Autor:
Elisa Salvati, Samuel Keeney, Itzhak Nissim, Emmett Fitzpatrick, Giovanni Ferrari, Arbi E Aghali, Halley J Shukla, Robert C. Gorman, Robert J. Levy, Lubica Rauova, Abba M. Krieger, Vaishali V. Inamdar, Juan B. Grau, Estibaliz Castillero, Stanley J. Stachelek, Chase R. Brown, Nancy Rioux
AimsHeart valve disease attributed to serotonin (5HT) has been observed with 5HT-secreting carcinoid tumors and in association with medications, such as the diet drug, Dexfenfluoramine, a serotonin transporter (SLC6A4) inhibitor and 5HT receptor (HTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723286e0335d5712cdfc3c74d1e7bcf0
https://doi.org/10.1101/2020.03.10.985382
https://doi.org/10.1101/2020.03.10.985382
Autor:
George Bratinov, Lynn A. Spruce, Emmett Fitzpatrick, Ilia Fishbein, Ivan S. Alferiev, Vaishali V. Inamdar, Robert J. Levy, Stanley J. Stachelek, Steven H. Seeholzer, Chandrasekaran Nagaswami, Hossein Fazelinia
Publikováno v:
Acta Biomater
In-stent restenosis (ISR) and late stent thrombosis are the major complications associated with the use of metal stents and drug eluting stents respectively. Our lab previously investigated the use of peptide CD47 in improving biocompatibility of bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8193cf9b59283437050733709b5237
https://pubmed.ncbi.nlm.nih.gov/31935523
https://pubmed.ncbi.nlm.nih.gov/31935523
Autor:
Emmett Fitzpatrick, Lynn Bengston, Elaine Murray, Audrey V. Carr, Nancy G. Forger, Todd H. Ahern, Geert J. De Vries, Jill McCutcheon, Stefanie Krug
Publikováno v:
Journal of Comparative Neurology. 521:2551-2569
Naturally occurring cell death is essential to the development of the mammalian nervous system. Although the importance of developmental cell death has been appreciated for decades, there is no comprehensive account of cell death across brain areas i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a9e2f9f56c6a225ad11e0d9a9c1e051
https://doi.org/10.1002/cne.23298
https://doi.org/10.1002/cne.23298
Autor:
Brian O'Nuallain, Stephan Schilling, Jens-Ulrich Rahfeld, Marcelo F. DiCarli, Jeffrey L. Frost, Emmett Fitzpatrick, Kevin X. Le, William Trigg, Barbara J. Caldarone, Vladimir Reiser, Mi-Ae Park, Martin Kleinschmidt, Bin Liu, Inge Lues, Cynthia A. Lemere, Helen Crehan
Publikováno v:
Neurobiology of Aging. 39:S12-S13
Pyroglutamate-3 Av (pGlu-3 Av) is a highly pathogenic Av species in Alzheimer's disease (AD) brain. The Av N-terminus is truncated and the 3rd residue (glu) cyclized by glutaminyl cyclase, leading to increased aggregation and neurotoxicity. Previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95cd1bfd62f53d9c16bd6fa20b7e81f
https://doi.org/10.1016/j.neurobiolaging.2016.01.062
https://doi.org/10.1016/j.neurobiolaging.2016.01.062
Autor:
Todd H, Ahern, Stefanie, Krug, Audrey V, Carr, Elaine K, Murray, Emmett, Fitzpatrick, Lynn, Bengston, Jill, McCutcheon, Geert J, De Vries, Nancy G, Forger
Publikováno v:
The Journal of comparative neurology. 521(11)
Naturally occurring cell death is essential to the development of the mammalian nervous system. Although the importance of developmental cell death has been appreciated for decades, there is no comprehensive account of cell death across brain areas i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::921d440631313b50e137570c3369b347
https://pubmed.ncbi.nlm.nih.gov/23296992
https://pubmed.ncbi.nlm.nih.gov/23296992