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of 27
pro vyhledávání: '"Emmert DE"'
Publikováno v:
Repositório Institucional do FGVFundação Getulio VargasFGV.
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Externí odkaz:
http://hdl.handle.net/10438/11538
Publikováno v:
Journal of Medicinal Chemistry. 24:341-346
Derivatives of 4-aryl-4-(dimethylamino)cyclohexan-1-ones substituted by m-hydroxy groups were obtained by using as a key reaction the displacement of cyanide from the alpha-aminonitrile of 1,4-cyclohexanedione ketal, with the THP ether of m-hydroxyph
Publikováno v:
Journal of Medicinal Chemistry. 12:881-885
This paper describes preparation of several potent estrogen antagonists. The sequence preparation was: 1) formylating alpha-substituted beta-hydroxyacrylophenones (at alpha-C a phenyl or cyclopentyl group; at benzene; C-4 a hydroxy or methoxy group);
Publikováno v:
Journal of medicinal chemistry. 24(4)
The effect on potency of modification of the carbonyl function of analgesics derived from 4-(dimethylamino)-4-arylcyclohexan-1-one was studied by reduction and by addition of nucleophiles. The resulting amino alcohols were separated and assigned stru
Publikováno v:
Journal of medicinal chemistry. 23(4)
Investigation of central nervous system activity of phenylcyclohexylamines was continued by preparation of "reversed" analogues. Following the unexpected finding of analgesic activity with 1-(dimethylamino)-1-phenylcyclohexylamine, the SAR of the ser
Publikováno v:
Journal of medicinal chemistry. 9(1)
Publikováno v:
Journal of medicinal chemistry. 10(6)
Autor:
Hester JB; Department of Structural, Analytical & Medicinal Chemistry, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA. jackson.b.hester@pharmacia.com, Gibson JK, Buchanan LV, Cimini MG, Clark MA, Emmert DE, Glavanovich MA, Imbordino RJ, LeMay RJ, McMillan MW, Perricone SC, Squires DM, Walters RR
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2001 Mar 29; Vol. 44 (7), pp. 1099-115.
Autor:
Genin MJ; Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA. michael.j.genin@am.pnu.com, Allwine DA, Anderson DJ, Barbachyn MR, Emmert DE, Garmon SA, Graber DR, Grega KC, Hester JB, Hutchinson DK, Morris J, Reischer RJ, Ford CW, Zurenko GE, Hamel JC, Schaadt RD, Stapert D, Yagi BH
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2000 Mar 09; Vol. 43 (5), pp. 953-70.
Autor:
Genin MJ; Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA., Hutchinson DK, Allwine DA, Hester JB, Emmert DE, Garmon SA, Ford CW, Zurenko GE, Hamel JC, Schaadt RD, Stapert D, Yagi BH, Friis JM, Shobe EM, Adams WJ
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 1998 Dec 17; Vol. 41 (26), pp. 5144-7.