The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis.

Autor: Losa M; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland., Emmenegger M; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland., De Rossi P; Department of Quantitative Biomedicine, University of Zürich, Zurich, Switzerland., Schürch PM; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland., Serdiuk T; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland., Pengo N; Mabylon AG, Schlieren, Zurich, Switzerland., Capron D; Mabylon AG, Schlieren, Zurich, Switzerland., Bieli D; Mabylon AG, Schlieren, Zurich, Switzerland., Bargenda N; Department of Quantitative Biomedicine, University of Zürich, Zurich, Switzerland., Rupp NJ; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland., Carta MC; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland., Frontzek KJ; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland., Lysenko V; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland., Reimann RR; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland., Schwarz P; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland., Nuvolone M; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland.; Amyloidosis Research and Treatment Center, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, University of Pavia, Pavia, Italy., Westermark GT; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Nilsson KPR; Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden., Polymenidou M; Department of Quantitative Biomedicine, University of Zürich, Zurich, Switzerland., Theocharides AP; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland., Hornemann S; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland., Picotti P; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland., Aguzzi A; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland. adriano.aguzzi@usz.ch.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2024 Sep; Vol. 16 (9), pp. 2024-2042. Date of Electronic Publication: 2024 Jul 30.

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid.

Autor: Cervia-Hasler C; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Brüningk SC; Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., Hoch T; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Fan B; Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., Muzio G; Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., Thompson RC; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ceglarek L; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Meledin R; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Westermann P; Precision Proteomics Center, Swiss Institute of Allergy and Asthma Research, University of Zurich, 7265 Davos, Switzerland., Emmenegger M; Institute of Neuropathology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Taeschler P; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Zurbuchen Y; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Pons M; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Menges D; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, 8001 Zurich, Switzerland., Ballouz T; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, 8001 Zurich, Switzerland., Cervia-Hasler S; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Adamo S; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Merad M; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Charney AW; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Puhan M; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, 8001 Zurich, Switzerland., Brodin P; Unit for Clinical Pediatrics, Department of Women's and Children's Health, Karolinska Institute, 17165 Solna, Sweden.; Department of Immunology and Inflammation, Imperial College London, London W12 0NN, UK., Nilsson J; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Aguzzi A; Institute of Neuropathology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Raeber ME; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Messner CB; Precision Proteomics Center, Swiss Institute of Allergy and Asthma Research, University of Zurich, 7265 Davos, Switzerland., Beckmann ND; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Data Driven and Digital Medicine (D3M), Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Borgwardt K; Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., Boyman O; Department of Immunology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.; Faculty of Medicine and Faculty of Science, University of Zurich, 8006 Zurich, Switzerland.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Jan 19; Vol. 383 (6680), pp. eadg7942. Date of Electronic Publication: 2024 Jan 19.

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Protocol to determine antibody affinity and concentration in complex solutions using microfluidic antibody affinity profiling.

Autor: Emmenegger M; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland. Electronic address: marc.emmenegger@usz.ch., Worth R; Fluidic Analytics, Unit A, The Paddocks Business Centre, Cherry Hinton Road, Cambridge CB1 8DH, UK., Fiedler S; Fluidic Analytics, Unit A, The Paddocks Business Centre, Cherry Hinton Road, Cambridge CB1 8DH, UK., Devenish SRA; Fluidic Analytics, Unit A, The Paddocks Business Centre, Cherry Hinton Road, Cambridge CB1 8DH, UK., Knowles TPJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK; Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK., Aguzzi A; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland. Electronic address: adriano.aguzzi@usz.ch.

Publikováno v: STAR protocols [STAR Protoc] 2023 Mar 17; Vol. 4 (1), pp. 102095. Date of Electronic Publication: 2023 Feb 13.

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.

Autor: Emmenegger M; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., De Cecco E; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Lamparter D; Health2030 Genome Center, 9 Chemin des Mines, 1202 Geneva, Switzerland., Jacquat RPB; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.; Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK., Riou J; Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland., Menges D; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland., Ballouz T; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland., Ebner D; Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, England., Schneider MM; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Morales IC; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Doğançay B; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Guo J; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Wiedmer A; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Domange J; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Imeri M; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Moos R; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Zografou C; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Batkitar L; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Madrigal L; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Schneider D; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Trevisan C; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Gonzalez-Guerra A; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Carrella A; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Dubach IL; Division of Internal Medicine, University Hospital Zurich, 8091 Zurich, Switzerland., Xu CK; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Meisl G; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Kosmoliaptsis V; Department of Surgery, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK.; NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK., Malinauskas T; Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK., Burgess-Brown N; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK., Owens R; Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.; The Rosalind Franklin Institute, Harwell Campus, Oxford OX11 0FA, UK., Hatch S; Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, England., Mongkolsapaya J; Nuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Screaton GR; Nuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Schubert K; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland., Huck JD; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Liu F; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Pojer F; Protein Production and Structure Core Facility, EPFL SV PTECH PTPSP, 1015 Lausanne, Switzerland., Lau K; Protein Production and Structure Core Facility, EPFL SV PTECH PTPSP, 1015 Lausanne, Switzerland., Hacker D; Protein Production and Structure Core Facility, EPFL SV PTECH PTPSP, 1015 Lausanne, Switzerland., Probst-Müller E; Department of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland., Cervia C; Department of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland., Nilsson J; Department of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland., Boyman O; Department of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland.; Faculty of Medicine, University of Zurich, 8006 Zurich, Switzerland., Saleh L; Institute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland., Spanaus K; Institute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland., von Eckardstein A; Institute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland., Schaer DJ; Division of Internal Medicine, University Hospital Zurich, 8091 Zurich, Switzerland., Ban N; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland., Tsai CJ; Department of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, 5303 Villigen-PSI, Switzerland., Marino J; Department of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, 5303 Villigen-PSI, Switzerland., Schertler GFX; Department of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, 5303 Villigen-PSI, Switzerland.; Department of Biology, ETH Zürich, 8093 Zürich, Switzerland., Ebert N; Institute of Virology and Immunology, 3012 Bern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Thiel V; Institute of Virology and Immunology, 3012 Bern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Gottschalk J; Regional Blood Transfusion Service Zurich, Swiss Red Cross, 8952 Schlieren, Switzerland., Frey BM; Regional Blood Transfusion Service Zurich, Swiss Red Cross, 8952 Schlieren, Switzerland., Reimann RR; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Hornemann S; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Ring AM; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Knowles TPJ; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.; Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK., Puhan MA; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland., Althaus CL; Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland., Xenarios I; Health2030 Genome Center, 9 Chemin des Mines, 1202 Geneva, Switzerland.; Agora Center, University of Lausanne, 25 Avenue du Bugnon, 1005 Lausanne, Switzerland., Stuart DI; Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK., Aguzzi A; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.

Publikováno v: IScience [iScience] 2023 Feb 17; Vol. 26 (2), pp. 105928. Date of Electronic Publication: 2023 Jan 04.