A novel piperine analogue exerts in vivo antitumor effect by inducing oxidative, antiangiogenic and immunomodulatory actions

Autor: Rafael Carlos Ferreira, Tatianne Mota Batista, Sâmia Sousa Duarte, Daiana Karla Frade Silva, Thaís Mangeon Honorato Lisboa, Raquel Fragoso Pereira Cavalcanti, Fagner Carvalho Leite, Vivianne Mendes Mangueira, Tatyanna Kélvia Gomes de Sousa, Renata Albuquerque de Abrantes, Emmely Oliveira da Trindade, Petrônio Filgueiras de Athayde-Filho, Maria Cláudia Rodrigues Brandão, Karina Carla de Paula Medeiros, Davi Felipe Farias, Marianna Vieira Sobral

Publikováno v: Biomedicine & Pharmacotherapy, Vol 128, Iss , Pp 110247- (2020)

Structural diversity characterizes natural products as prototypes for design of lead compounds. The aim of this study was to synthetize, and to evaluate the toxicity and antitumor action of a new piperine analogue, the butyl 4-(4-nitrobenzoate)-piper

Externí odkaz: https://doaj.org/article/99e05efa6cdc4eb3b28a4e1491bbd39c

Synthesis, Spectroscopic Characterization, DFT Calculations and Preliminary Antifungal Activity of New Piperine Derivatives

Autor: Edeltrudes de Oliveira Lima, José Maria Barbosa-Filho, Laísa Vilar Cordeiro, Evandro Paulo Soares Martins, Rafael F. de Oliveira, Gerd B. Rocha, Emmely Oliveira Da Trindade, Joselito S. Souza Jr., Helivaldo Diógenes da Silva Souza, Francinara Da Silva Alves, Bruno F. Lira, Petrônio Filgueiras de Athayde-Filho

Publikováno v: Journal of the Brazilian Chemical Society v.32 n.3 2021
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 32, Issue: 3, Pages: 490-502, Published: 01 MAR 2021

Four new piperine derivatives, PC1-PC4, were synthesized, and their structures were fully characterized by infrared (IR) and 1H and 13C nuclear magnetic resonance (NMR) spectroscopies. Quantum chemical calculations were performed using density functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e87ee792514c2e88f9b16d2ddbad78
https://doi.org/10.21577/0103-5053.20200203

Lignocellulosic Residues from the Brazilian Juice Processing Industry as Novel Sustainable Sources for Bioenergy Production: Preliminary Assessment Using Physicochemical Characteristics

Autor: Guilherme Davi Mumbach, Rennio Felix de Sena, Jean Constantino Gomes da Silva, Emmely Oliveira Da Trindade, José Luiz Francisco Alves, Petrônio Filgueiras de Athayde-Filho, Ricardo Francisco Alves, José Maria Barbosa Filho

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 31, Issue: 9, Pages: 1939-1948, Published: 19 AUG 2020
Journal of the Brazilian Chemical Society v.31 n.9 2020
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

This work aims to investigate the energy-related characteristics of apple bagasse, orange bagasse and cashew-apple bagasse to identify their potential as bioenergy feedstocks. For this, a detailed characterization was performed, including proximate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4722cca4b9b497ce88653de11ef701
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000901939&lng=en&tlng=en

Synthesis, in silico Study and Antimicrobial Activity of New Piperine Derivatives Containing Substituted δ-Esters

Autor: José Maria Barbosa-Filho, Thalisson Firmo Dutra, Bruno F. Lira, Hermes Diniz Neto, Emmely Oliveira Da Trindade, Edeltrudes de Oliveira Lima, Maria Cláudia Rodrigues Brandão, Petrônio Filgueiras de Athayde-Filho

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 31, Issue: 12, Pages: 2590-2602, Published: 14 DEC 2020
Journal of the Brazilian Chemical Society v.31 n.12 2020
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

A series of fifteen new piperine-derived diesters was synthesized through the substitution reaction between the salt of piperic acid, obtained through piperine basic hydrolysis, with the δ-chloro-esters, obtained through the cleavage of tetrahydrofu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d058a2835ae1d3e5b4d564ce4ea2e9b0
https://doi.org/10.21577/0103-5053.20200140

A novel piperine analogue exerts in vivo antitumor effect by inducing oxidative, antiangiogenic and immunomodulatory actions

Autor: Renata Albuquerque de Abrantes, Sâmia Sousa Duarte, Raquel Fragoso Pereira Cavalcanti, Fagner Carvalho Leite, Thaís Lisboa, Daiana Karla Frade Silva, Rafael Carlos Ferreira, Petrônio Filgueiras de Athayde-Filho, Tatianne Mota Batista, Marianna Vieira Sobral, Emmely Oliveira Da Trindade, Vivianne Mendes Mangueira, Karina Carla de Paula Medeiros, Tatyanna Kelvia Gomes de Sousa, Maria Cláudia Rodrigues Brandão, Davi Felipe Farias

Publikováno v: Biomedicine & Pharmacotherapy, Vol 128, Iss, Pp 110247-(2020)

Structural diversity characterizes natural products as prototypes for design of lead compounds. The aim of this study was to synthetize, and to evaluate the toxicity and antitumor action of a new piperine analogue, the butyl 4-(4-nitrobenzoate)-piper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfaec3f723f8d4e198b031cad8ab578c
https://doi.org/10.1016/j.biopha.2020.110247