Výsledky vyhledávání - "Emmely E. Treffers"

Akademický článek

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.

Autor: Emmely E Treffers, Ali Tas, Florine E M Scholte, Arnoud H de Ru, Eric J Snijder, Peter A van Veelen, Martijn J van Hemert

Publikováno v: PLoS Pathogens, Vol 19, Iss 2, p e1011179 (2023)

Chikungunya virus (CHIKV) is a reemerging alphavirus. Since 2005, it has infected millions of people during outbreaks in Africa, Asia, and South/Central America. CHIKV replication depends on host cell factors at many levels and is expected to have a

Externí odkaz: https://doaj.org/article/aa1beee5baf04d92bb34ba28532c4197

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Molecular characterization of the RNA-protein complex directing -2/-1 programmed ribosomal frameshifting during arterivirus replicase expression

Autor: Trushar R. Patel, Markus Meier, Eric J. Snijder, Emmely E. Treffers, Brian L. Mark, Ankoor Patel, Jörg Stetefeld

Publikováno v: The Journal of Biological Chemistry
Journal of Biological Chemistry, 295(52), 17904-17921. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

Programmed ribosomal frameshifting (PRF) is a mechanism used by arteriviruses like porcine reproductive and respiratory syndrome virus (PRRSV) to generate multiple proteins from overlapping reading frames within its RNA genome. PRRSV employs -1 PRF d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85addb77d1ba8f3f6c2470f63222838
https://pubmed.ncbi.nlm.nih.gov/33127640

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A novel role for poly(C) binding proteins in programmed ribosomal frameshifting

Autor: Sawsan Napthine, Eric J. Snijder, Andrew E. Firth, Susanne Bell, Ian Brierley, Ian Goodfellow, Ying Fang, Emmely E. Treffers

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 44(12), 5491-5503. OXFORD UNIV PRESS

Translational control through programmed ribosomal frameshifting (PRF) is exploited widely by viruses and increasingly documented in cellular genes. Frameshifting is induced by mRNA secondary structures that compromise ribosome fidelity during decodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474a453c713e23b246517c20f49aff96

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Non-invasive prenatal diagnosis of beta-thalassemia and sickle-cell disease using pyrophosphorolysis-activated polymerization and melting curve analysis

Autor: Cornelis L. Harteveld, Warsha A. Kanhai, Supawadee Yamsri, Marion Phylipsen, Egbert Bakker, Diahann T. S. L. Jansen, Supan Fucharoen, Emmely E. Treffers, Piero C. Giordano, Elles M. J. Boon

Publikováno v: Prenatal Diagnosis. 32:578-587

Objective The aim of this study was to develop a pyrophosphorolysis-activated polymerization (PAP) assay for non-invasive prenatal diagnosis (NIPD) of β-thalassemia major and sickle-cell disease (SCD). PAP is able to detect mutations in free fetal D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e2cd573430569cad950c78b62f24580
https://doi.org/10.1002/pd.3864

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Transactivation of programmed ribosomal frameshifting by a viral protein

Autor: Ali Tas, Sawsan Napthine, Yanhua Li, Zhi Sun, Martijn J. van Hemert, Emmely E. Treffers, Brian L. Mark, Peter A. van Veelen, Eric J. Snijder, Ian Brierley, Longchao Zhu, Andrew E. Firth, Susanne Bell, Ying Fang

Publikováno v: Proceedings of the National Academy of Sciences, 111(21), E2172-E2181
Proceedings of the National Academy of Sciences

Programmed −1 ribosomal frameshifting (−1 PRF) is a widely used translational mechanism facilitating the expression of two polypeptides from a single mRNA. Commonly, the ribosome interacts with an mRNA secondary structure that promotes −1 frame

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912893bba649ad2a7a89efc731a7a415
http://hdl.handle.net/1887/102888

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Non-invasive prenatal diagnosis of beta-thalassemia and sickle-cell disease using pyrophosphorolysis-activated polymerization and melting curve analysis

Autor: Marion, Phylipsen, Supawadee, Yamsri, Emmely E, Treffers, Diahann T S L, Jansen, Warsha A, Kanhai, Elles M J, Boon, Piero C, Giordano, Supan, Fucharoen, Egbert, Bakker, Cornelis L, Harteveld

Publikováno v: Prenatal diagnosis. 32(6)

The aim of this study was to develop a pyrophosphorolysis-activated polymerization (PAP) assay for non-invasive prenatal diagnosis (NIPD) of β-thalassemia major and sickle-cell disease (SCD). PAP is able to detect mutations in free fetal DNA in a hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b4221b88e02405511ece9c9d7b0599a
https://pubmed.ncbi.nlm.nih.gov/22517437

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