Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Emme C.K. Lin"'
Autor:
Allister Fraser, Kevin R. Shreder, Junichi Ishiyama, John W. Kozarich, Yi Hu, Yasushi Kohno, Heidi E. Brown, Lingling Du, Eric Okerberg, Christopher M. Amantea, Julia Cajica, Emme C.K. Lin, Lan M. Pham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1553-1556
AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid, was identified as a Zn2+-dependent, 27 nM inhibitor of human plasma Lp-PLA2. Structure–activity relationship studies focused on the AX10479 2-phenylamide gro
Autor:
Helge Weissig, Shyama Sidique, John W. Kozarich, Emme C.K. Lin, Tyzoon K. Nomanbhoy, Jonathan S. Rosenblum, Junichi Ishiyama, Yi Hu, Bei Li, Christopher M. Amantea
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is embryonic lethal, and tissue-restricted dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa0e539b27866c3e1d8419d25b4f8e3
https://europepmc.org/articles/PMC5081620/
https://europepmc.org/articles/PMC5081620/
Autor:
Helge Weissig, Bei Li, Junichi Ishiyama, Yi Hu, Shyama Sidique, Tyzoon K. Nomanbhoy, Jonathan S. Rosenblum, Emme C.K. Lin, Christopher A. Amantea, John W. Kozarich
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is embryonic lethal and tissue-restricted delet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb49cdb1aa5edb36cb53312a114b6d1f
https://doi.org/10.1101/038513
https://doi.org/10.1101/038513
Autor:
Eric Okerberg, Julia Cajica, Kevin R. Shreder, Yasushi Kohno, Lan M. Pham, Heidi E. Brown, Junichi Ishiyama, Yi Hu, John W. Kozarich, Allister Fraser, Lingling Du, Emme C.K. Lin, Christopher M. Amantea
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:868-871
AX10185, the phenyl amide of xanthurenic acid, was found to be a sub-100 nM inhibitor of Lp-PLA2. However, in the presence of EDTA the inhibitory activity of AX10185 was extinguished while the enzymatic activity of Lp-PLA2 did not change. Subsequent
Autor:
Emme C.K. Lin, Jami Mandelin, Dana D. Hu, E. Helene Sage, Renata Pasqualini, Jeffrey W. Smith, Kim Anh Do, Wadih Arap, Susan K. Knowles, Xuemei Wang
Publikováno v:
Cancer. 115:1753-1764
BACKGROUND: Osteopontin affects several steps of the metastatic cascade. Despite direct correlation with metastasis in experimental systems and in patient studies, the extracellular and intracellular basis for these observations remains unsolved. In
Autor:
Melissa C. Zhang, Min Wu, Melissa Wong, Kevin Shreder, Sergio Corral, Yi Hu, Lisa Morera, Lifu Ma, Emme C.K. Lin, John W. Kozarich, Doris Pik-Yiu Chun
Publikováno v:
Letters in Drug Design & Discovery. 5:340-345
Publikováno v:
International Journal of Cancer. 107:528-534
Mammary carcinoma frequently metastasizes to specific organs, including the regional lymph nodes, the lung and bone marrow. The mechanisms that guide organ-specific metastasis and the molecular players that are involved remain to be established. To g
Publikováno v:
Cell Adhesion and Communication. 6:451-464
The alpha v beta 3 integrin plays a critical role in bone resorption, angiogenesis, and tumor cell invasion. A blockade of this receptor has therapeutic potential in osteoporosis, vascular restenosis, and cancer. In this report, we characterize the m
Autor:
Emme C.K. Lin, Barbara M. Mueller, Peter G. Ruminski, Jeffrey W. Smith, Vito Quaranta, Nanette C. Wong, Carlos F. Barbas
Publikováno v:
Clinical and Experimental Metastasis. 16:50-61
Integrins with the αv subunit are involved in cell adhesion and cellular signaling. Some αv integrins have been associated with tumor progression and dissemination. The objective of this study was to assess the contribution of αv integrins to the
Publikováno v:
Journal of Biological Chemistry. 270:26232-26238
Osteopontin (OPN) is an extracellular matrix protein that binds to integrin αvβ3. Here we demonstrate that two other integrins, αvβ1 and αvβ5, are also receptors for OPN. Human embryonic kidney 293 cells adhere to human recombinant osteopontin