Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Emmanuelle Supper"'
Autor:
Emmanuelle Supper, Saskia Rudat, Vivek Iyer, Alastair Droop, Kim Wong, Jean-François Spinella, Patrick Thomas, Guy Sauvageau, David J. Adams, Chi C. Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Cut-like homeobox 1 (CUX1) is a haploinsufficient tumor suppressor commonly inactivated in acute myeloid leukemia and high-risk myelodysplasia. Here, in a genetically modified murine model, the authors show that CUX1 deficiency impairs apoptosis lead
Externí odkaz:
https://doaj.org/article/dda81ff46bb244da8bbf4aca6a147a93
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Staphylococcal and streptococcal superantigens are virulence factors that cause toxic shock by hyperinducing inflammatory cytokines. Effective T-cell activation requires interaction between the principal costimulatory receptor CD28 and its two coliga
Externí odkaz:
https://doaj.org/article/6b2abfbc8a7b440e9f7c05f9b76cb134
Autor:
Gila Arad, Revital Levy, Iris Nasie, Dalia Hillman, Ziv Rotfogel, Uri Barash, Emmanuelle Supper, Tomer Shpilka, Adi Minis, Raymond Kaempfer
Publikováno v:
PLoS Biology, Vol 13, Iss 8, p e1002237 (2015)
Externí odkaz:
https://doaj.org/article/a3404a90428d4020b2cf09124f5e6d82
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134026 (2015)
Expression of the Bcr-Abl fusion gene in hematopoietic progenitor cells (HPCs) results in the development of chronic myelogenous leukemia (CML), for which hematopoietic microenvironment plays an important role. We investigated the specific effects of
Externí odkaz:
https://doaj.org/article/79d8104fb5d248ccb07380c1d0d9ebd8
Autor:
Gila Arad, Revital Levy, Iris Nasie, Dalia Hillman, Ziv Rotfogel, Uri Barash, Emmanuelle Supper, Tomer Shpilka, Adi Minis, Raymond Kaempfer
Publikováno v:
PLoS Biology, Vol 9, Iss 9, p e1001149 (2011)
Bacterial superantigens, a diverse family of toxins, induce an inflammatory cytokine storm that can lead to lethal shock. CD28 is a homodimer expressed on T cells that functions as the principal costimulatory ligand in the immune response through an
Externí odkaz:
https://doaj.org/article/2c5298f26ef74f0fa8ebd46414d22eec
Autor:
Patrick Thomas, David J. Adams, Chi C. Wong, Emmanuelle Supper, Saskia S. Rudat, Vivek Iyer, Alastair Droop, Jean-François Spinella, Guy Sauvageau, Kim Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
While oncogenes promote tumorigenesis, they also induce deleterious cellular stresses, such as apoptosis, that cancer cells must combat by coopting adaptive responses. Whether tumor suppressor gene haploinsufficiency leads to such phenomena and their
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Staphylococcal and streptococcal superantigens are virulence factors that cause toxic shock by hyperinducing inflammatory cytokines. Effective T-cell activation requires interaction between the principal costimulatory receptor CD28 and its two coliga
Autor:
Anneliese O. Speak, Marcela Sjoberg, van Dongen S, Nicholas K. Hayward, Jyoti S. Choudhary, Clara Alsinet, Graham R. Bignell, Kim Wong, Antonia L. Pritchard, Theodoros I. Roumeliotis, Mamunur Rashid, David J. Adams, David Tamborero, Velasco-Herrera Mdc, Nicola A. Thompson, Julia Newton-Bishop, Fiona M. Behan, Sofia Y. Chen, Emmanuelle Supper, Kosuke Yusa, Ultan McDermott, Chi C. Wong, L. Wessels, Anton J. Enright, Aida Shahrabi, Nanne Aben, Oscar Krijgsman, Marco Ranzani, Daniel S. Peeper, Magali Michaut, Kristel Kemper, Grinkevich, Ken Dutton-Regester, Mathew J. Garnett, Jérémie Nsengimana, Iyer, Francesco Iorio, Gemma Turner
Despite recent therapeutic advances in the management ofBRAFV600-mutant melanoma, there is still a compelling need for more effective treatments for patients who developedBRAF/NRASwild type disease. Since the activity of single targeted agents is lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f96e636071c9cde8ad0883e2073c4d
https://doi.org/10.1101/195354
https://doi.org/10.1101/195354
Autor:
Emmanuelle Supper, Ziv Rotfogel, Dalia Hillman, Revital Levy, Farhat Osman, Gila Arad, Andrey Popugailo, Raymond Kaempfer
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Full T-cell activation requires interaction between the costimulatory receptors B7-2 and CD28. By binding CD28, bacterial superantigens elicit harmful inflammatory cytokine overexpression through an unknown mechanism. We show that, by engaging not on
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 7, p e0134026 (2015)
PLoS ONE, Vol 10, Iss 7, p e0134026 (2015)
Expression of the Bcr-Abl fusion gene in hematopoietic progenitor cells (HPCs) results in the development of chronic myelogenous leukemia (CML), for which hematopoietic microenvironment plays an important role. We investigated the specific effects of