Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Emmanuelle Saint-Germain"'
Autor:
Gerardo Ferbeyre, Frédéric Lessard, Subburaj Ilangumaran, Marie-Camille Rowell, Véronique Bourdeau, Viviane Calabrese, Karine Moineau-Vallée, Mariana Acevedo, Geneviève Huot, Lian Mignacca, Emmanuelle Saint-Germain
Expression of the suppressor of cytokine signaling-1 (SOCS1) is inactivated in hematopoietic and solid cancers by promoter methylation, miRNA-mediated silencing, and mutations. Paradoxically, SOCS1 is also overexpressed in many human cancers. We repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c32dad5852852b3d66ab965c8d549e
https://doi.org/10.1158/0008-5472.c.6510758
https://doi.org/10.1158/0008-5472.c.6510758
Autor:
Xavier Deschênes-Simard, Marlene Oeffinger, Cornelia E. Zorca, Sebastian Igelmann, Léa Brakier-Gingras, Daniel Zenklusen, Emmanuelle Saint-Germain, Olga Moiseeva, Geneviève Huot, Neylen Del Toro, Lian Mignacca, Benjamin Le Calvé, Marinieve Montero, Marie-Camille Rowell, Frédéric Lessard, Véronique Bourdeau, Gerardo Ferbeyre, Christian Trahan, Marina Bury, Stéphane Lopes-Paciencia
Publikováno v:
Nature Cell Biology. 20:789-799
Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle arrest. Here we report that cellular senescence triggered by a variety of stimuli leads to diminished ribosome biogenesis and the accumulation of both rRNA prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73568848198ad7a458ebe043b524f17e
https://doi.org/10.1038/s41556-018-0127-y
https://doi.org/10.1038/s41556-018-0127-y
Autor:
Subburaj Ilangumaran, Mathieu Vernier, Emmanuelle Saint-Germain, Diwakar Bobbala, Gerardo Ferbeyre, Lian Mignacca
Publikováno v:
Aging
Aging, Impact Journals, 2017, 9 (10), pp.2137-2162. ⟨10.18632/aging.101306⟩
Aging (Albany NY)
Aging, Impact Journals, 2017, 9 (10), pp.2137-2162. ⟨10.18632/aging.101306⟩
Aging (Albany NY)
The mechanism by which p53 suppresses tumorigenesis remains poorly understood. In the context of aberrant activation of the JAK/STAT5 pathway, SOCS1 is required for p53 activation and the regulation of cellular senescence. In order to identify p53 ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4544349f143fde92b46bf8ffbc69bf22
https://doi.org/10.18632/aging.101306
https://doi.org/10.18632/aging.101306
Publikováno v:
Oncoscience
Suppressor of cytokine signaling (SOCS) family members are upregulated following JAK-STAT pathway activation by cytokines. SOCS proteins are recognized inhibitors of cytokine signaling playing roles in cell growth and differentiation. Moreover, SOCS1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425f6b6e59b01d6ea4a364f6e0666209
https://pubmed.ncbi.nlm.nih.gov/31984217
https://pubmed.ncbi.nlm.nih.gov/31984217
Autor:
Gerardo Ferbeyre, Paloma Kalegari, Léa Brakier-Gingras, Emmanuelle Saint-Germain, Sebastian Igelmann, Mehdi Benfdil, Lian Mignacca, Véronique Bourdeau, Marie-Camille Rowell, Neylen Del Toro, Ana Fernandez-Ruiz, Frédéric Lessard, Stéphane Lopes-Paciencia
Senescence is a tumor suppressor program characterized by a stable growth arrest while maintaining cell viability. Senescence-associated ribogenesis defects (SARD) have been shown to regulate senescence through the ability of the ribosomal protein S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba23de22e1eda67ba431f1b1cd846602
https://europepmc.org/articles/PMC6464582/
https://europepmc.org/articles/PMC6464582/
Autor:
Geneviève Huot, Marie-Camille Rowell, Subburaj Ilangumaran, Viviane Calabrese, Mariana Acevedo, Emmanuelle Saint-Germain, Frédéric Lessard, Lian Mignacca, Gerardo Ferbeyre, Véronique Bourdeau, Karine Moineau-Vallée
Publikováno v:
Cancer research. 79(13)
Expression of the suppressor of cytokine signaling-1 (SOCS1) is inactivated in hematopoietic and solid cancers by promoter methylation, miRNA-mediated silencing, and mutations. Paradoxically, SOCS1 is also overexpressed in many human cancers. We repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a3af8d092a45da1a6195da80e0a26e
https://pubmed.ncbi.nlm.nih.gov/31101761
https://pubmed.ncbi.nlm.nih.gov/31101761
Autor:
Marie-France Gaumont-Leclerc, Laurent Doucet, Gerardo Ferbeyre, Véronique Bourdeau, Alejandro Moro, Emmanuelle Saint-Germain, Mathieu Vernier, Geneviève Huot
Publikováno v:
Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2014, 25 (5), pp.554-565. ⟨10.1091/mbc.E13-02-0110⟩
Molecular Biology of the Cell, American Society for Cell Biology, 2014, 25 (5), pp.554-565. ⟨10.1091/mbc.E13-02-0110⟩
CHES1/FOXN3 inhibits cell proliferation and protein biosynthesis in tumor cell lines but not in normal fibroblasts. CHES1 directly represses the expression of the gene coding for the protein kinase PIM2, and PIM2 or eIF4E counteracts the antiprolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af58b6a36108d5d1797ccb0e33c782e0
https://doi.org/10.1091/mbc.e13-02-0110
https://doi.org/10.1091/mbc.e13-02-0110
Autor:
Xavier Deschênes-Simard, Marie Camille Rowell, Karine Moineau-Vallée, Benjamin Le Calvé, Nabeel Bardeesy, Sebastian Igelmann, Filippos Kottakis, Maxime Parisotto, Gerardo Ferbeyre, Paloma Kalegari, Emmanuelle Saint-Germain, Véronique Bourdeau
Publikováno v:
Aging Cell
Most cancers arise in old individuals, which also accumulate senescent cells. Cellular senescence can be experimentally induced by expression of oncogenes or telomere shortening during serial passage in culture. In vivo, precursor lesions of several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6532e18d8588cf2346f581f9051742cc
https://researchportal.unamur.be/en/publications/14d1d7b6-7d66-4639-ae5e-8d3d21c3fe17
https://researchportal.unamur.be/en/publications/14d1d7b6-7d66-4639-ae5e-8d3d21c3fe17
Autor:
Gerardo Ferbeyre, Alexandre Benoit, Lian Mignacca, Véronique Bourdeau, Alejandro Moro, Emmanuelle Saint-Germain
Publikováno v:
Cytokine. 82
Normal cell proliferation is controlled by a balance between signals that promote or halt cell proliferation. Micro RNAs are emerging as key elements in providing fine signal balance in different physiological situations. Here we report that STAT5 si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317df8d7e571b56c588460b4f4155bde
https://pubmed.ncbi.nlm.nih.gov/26841929
https://pubmed.ncbi.nlm.nih.gov/26841929
Autor:
Frédéric Lessard, Véronique Bourdeau, Julien Fitamant, Filippos Kottakis, Karine Moineau-Vallée, Benjamin Le Calvé, Nabeel Bardeesy, Xavier Deschenes-Ximard, Gerardo Ferbeyre, Emmanuelle Saint-Germain, Rushika M. Perera
Publikováno v:
Cancer Research. 75:2154-2154
Reprogrammation of cancer cells into stem-like state is one the most important mechanisms implicated in tumor initiation, metastasis and resistance to chemotherapies. Acquisition of stem-like cell property is directly correlated with the level of act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a4bc4b8ab4349cf63020a1388cfdf27
https://doi.org/10.1158/1538-7445.am2015-2154
https://doi.org/10.1158/1538-7445.am2015-2154