The 26RFa (QRFP)/GPR103 neuropeptidergic system in mice relays insulin signalling into the brain to regulate glucose homeostasis

Autor: Mouna El Mehdi, Saloua Takhlidjt, Mélodie Devère, Arnaud Arabo, Marie-Anne Le Solliec, Julie Maucotel, Alexandre Bénani, Emmanuelle Nedelec, Céline Duparc, Benjamin Lefranc, Jérôme Leprince, Youssef Anouar, Gaëtan Prévost, Nicolas Chartrel, Marie Picot

Publikováno v: Diabetologia. 65:1198-1211

26RFa (pyroglutamilated RFamide peptide [QRFP]) is a biologically active peptide that regulates glucose homeostasis by acting as an incretin and by increasing insulin sensitivity at the periphery. 26RFa is also produced by a neuronal population local

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9509fc25aae09a01db660f73dc0114
https://doi.org/10.1007/s00125-022-05706-5

Interactions between the regulatory peptide 26RFa (QRFP) and insulin in the regulation of glucose homeostasis in two complementary models: The high fat 26RFa-deficient mice and the streptozotocin insulin-deficient mice

Autor: Marie-Anne Le Solliec, Arnaud Arabo, Saloua Takhlidjt, Julie Maucotel, Mélodie Devère, Hind Berrahmoune, Alexandre Bénani, Emmanuelle Nedelec, Benjamin Lefranc, Jérôme Leprince, Marie Picot, Nicolas Chartrel, Gaëtan Prévost

Publikováno v: Neuropeptides
Neuropeptides, 2023, 98, pp.102326. ⟨10.1016/j.npep.2023.102326⟩

International audience; The regulatory peptide 26RFa (QRFP) is involved in the control of glucose homeostasis at the periphery by acting as an incretin, and in the brain by mediating the central antihyperglycemic effect of insulin, indicating the occ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fd2f718363a956f4733e4c89cfdc97
https://doi.org/10.1016/j.npep.2023.102326

Glucose homeostasis is impaired in mice deficient for the neuropeptide 26RFa (QRFP)

Autor: Mouna El Mehdi, Saloua Takhlidjt, Fayrouz Khiar, Gaëtan Prévost, Jean-Luc do Rego, Jean-Claude do Rego, Alexandre Bénani, Emmanuelle Nedelec, David Godefroy, Arnaud Arabo, Benjamin Lefranc, Jérôme Leprince, Youssef Anouar, Nicolas Chartrel, Marie Picot

Introduction26RFa (QRFP) is a biologically active peptide that has been found to control feeding behaviour by stimulating food intake, and to regulate glucose homeostasis by acting as an incretin. The aim of the present study was thus to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23d3ae5bd5fa3110e9b7471af06afdb

Crosstalk between hypothalamic neurons and olfactory system: a tracing and anatomo-fuctional investigation in mouse

Autor: Sylvia Ortega Martinez, Sylvie Chaudy, Aleth Lemoine, Emmanuelle Nedelec, Kheira Bettayeb, Caroline Rigault, Alexandre Benani, Luc Pénicaud, Jean Gascuel, Frédérique Datiche

Publikováno v: Chemical Senses
Proceedings of the Annual Meeting of the European-Chemoreception-Research-Organization (ECRO)
24. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO)
24. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Sep 2014, Dijon, France. 2 p
24. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Sep 2014, Dijon, France. Oxford University Press, 40 (3), 2 p., 2015, Chemical Senses
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::69b56893710d0672fb8b7cc693c7c337
https://hal.archives-ouvertes.fr/hal-01234399

Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal

Autor: Danaé Nuzzaci, Céline Cansell, Fabienne Liénard, Emmanuelle Nédélec, Selma Ben Fradj, Julien Castel, Ewout Foppen, Raphael Denis, Dominique Grouselle, Amélie Laderrière, Aleth Lemoine, Alexia Mathou, Virginie Tolle, Tony Heurtaux, Xavier Fioramonti, Etienne Audinat, Luc Pénicaud, Jean-Louis Nahon, Carole Rovère, Alexandre Benani

Publikováno v: Cell Reports, Vol 30, Iss 9, Pp 3067-3078.e5 (2020)

Summary: Mechanistic studies in rodents evidenced synaptic remodeling in neuronal circuits that control food intake. However, the physiological relevance of this process is not well defined. Here, we show that the firing activity of anorexigenic POMC

Externí odkaz: https://doaj.org/article/d5284aaafefd4a588b4cedece0e6efec