Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Emmanuelle M. Blanc"'
Publikováno v:
Journal of Neurochemistry. 68:1870-1881
Amyloid beta-peptide (A beta) is deposited as insoluble fibrils in the brain parenchyma and cerebral blood vessels in Alzheimer's disease (AD). In addition to neuronal degeneration, cerebral vascular alterations indicative of damage to vascular endot
Publikováno v:
Journal of Neurochemistry. 69:570-580
Considerable data indicate that oxidative stress and membrane lipid peroxidation contribute to neuronal degeneration in an array of age-related neurodegenerative disorders. In contrast, the impact of subtoxic levels of membrane lipid peroxidation on
Publikováno v:
Journal of Neurochemistry. 70:958-970
We investigated the effect of uncoupling astrocytic gap junctions on neuronal vulnerability to oxidative injury in embryonic rat hippocampal cell cultures. Mixed cultures (neurons growing on an astrocyte monolayer) treated with 18-alpha-glycyrrhetini
Autor:
Graham S. Baldwin, Emmanuelle M. Blanc, Armelle Choquet, Debra J. Lee, Jean-Pierre Bali, Frédéric Hollande
Publikováno v:
Journal of Biological Chemistry. 276:40402-40410
The various molecular forms of gastrin can act as promoters of proliferation and differentiation in different regions of the gastrointestinal tract. We report a novel stimulatory effect of glycine-extended gastrin(17) only on cell/cell dissociation a
Autor:
Jean Pierre Bali, Frédéric Hollande, André Pèlegrin, Armelle Choquet, Emmanuelle M. Blanc, Graham S. Baldwin, Robert H. Whitehead
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 280:G910-G921
The regulation of intercellular adhesion by hepatocyte growth factor (HGF) was examined on a novel nontumorigenic gastric epithelial cell line (IMGE-5) derived from H-2Kb-tsA58 transgenic mice. IMGE-5 cells constitutively expressed cytokeratin 18 and
Publikováno v:
European Journal of Neuroscience. 11:3377-3386
We investigated the modulation by growth factors of phospholipase C (PLC)-linked glutamate receptors during in vitro development of hippocampal cultures. In defined medium, glial cells represent between 3 and 14% of total cell number. When we added b
Publikováno v:
Glia. 22:149-160
Astrocytes possess plasma membrane glutamate transporters that rapidly remove glutamate from the extracellular milieu and thereby prevent excitotoxic injury to neurons. Cellular oxidative stress is increased in neural tissues in a variety of acute an
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 10, Pp 2155-2167 (1997)
Diet-derived lipids may influence cytokine-mediated endothelial cell dysfunction, including TNF-induced apoptosis. To test this hypothesis, oxidative stress, intracellular calcium levels, endothelial barrier function, cell viability, and apoptosis we
Autor:
Koji Uchida, Mark P. Mattson, Jeffrey N. Keller, Georg Waeg, Robert J. Mark, Jeffrey D. Rothstein, Annadora J. Bruce, Emmanuelle M. Blanc
Publikováno v:
Neuroscience. 80:685-696
Removal of extracellular glutamate at synapses, by specific high-affinity glutamate transporters, is critical to prevent excitotoxic injury to neurons. Oxidative stress has been implicated in the pathogenesis of an array of prominent neurodegenerativ
Autor:
Mohan R. Rengen, Jeremiah F. Kelly, George S. Roth, Steven W. Barger, Emmanuelle M. Blanc, Robert J. Mark, Mark P. Mattson, Katsutoshi Furukawa
Publikováno v:
Proceedings of the National Academy of Sciences. 93:6753-6758
Cholinergic pathways serve important functions in learning and memory processes, and deficits in cholinergic transmission occur in Alzheimer disease (AD). A subset of muscarinic cholinergic receptors are linked to G-proteins that activate phospholipa