Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Emmanuelle Hodara"'
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Akademický článek
Bladder cancer cells shift rapidly and spontaneously to cisplatin-resistant oxidative phosphorylation that is trackable in real time
Autor: Tong Xu, Jason A. Junge, Alireza Delfarah, Yi-Tsung Lu, Cosimo Arnesano, Maheen Iqbal, Kevin Delijani, Tien-Chan Hsieh, Emmanuelle Hodara, Hemal H. Mehta, Pinchas Cohen, Nicholas A. Graham, Scott E. Fraser, Amir Goldkorn
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Genetic mutations have long been recognized as drivers of cancer drug resistance, but recent work has defined additional non-genetic mechanisms of plasticity, wherein cancer cells assume a drug resistant phenotype marked by altered epigeneti
Externí odkaz: https://doaj.org/article/61124d6369024ac5a8162156b065d51c
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2
Akademický článek
The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division
Autor: Ankur A. Gholkar, Silvia Senese, Yu-Chen Lo, Edmundo Vides, Ely Contreras, Emmanuelle Hodara, Joseph Capri, Julian P. Whitelegge, Jorge Z. Torres
Publikováno v: Cell Reports, Vol 14, Iss 2, Pp 180-188 (2016)
Mid1 and Mid2 are ubiquitin ligases that regulate microtubule dynamics and whose mutation is associated with X-linked developmental disorders. We show that astrin, a microtubule-organizing protein, co-purifies with Mid1 and Mid2, has an overlapping l
Externí odkaz: https://doaj.org/article/d051a52e9f6c479d8de763092984610e
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3
Abstract 3908: M6A RNA modifications regulate expression of transcripts that promote transition to cisplatin resistance in bladder cancer
Autor: Emmanuelle Hodara, Aubree Mades, Tong Xu, Amir Goldkorn, Suhn Rhie
Publikováno v: Cancer Research. 83:3908-3908
BACKGROUND: Chemotherapy resistance is recognized to occur not only through selection of pre-existing genetically resistant clones, but also through rapid phenotypic plasticity mechanisms. We previously reported that bladder cancer cells can rapidly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::440f95ee5493166e24795098bd0cdde5
https://doi.org/10.1158/1538-7445.am2023-3908
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4
Epigenetic plasticity potentiates a rapid cyclical shift to and from an aggressive cancer phenotype
Autor: Rong Xu, Suhn K. Rhie, Hemant Gujar, Amir Goldkorn, Gareth Morrison, Kimberly D. Siegmund, Jenny Wei, Meng Li, Emmanuelle Hodara, Tong Xu, Gangning Liang, Tien‐Chan Hsieh, Hong-Tao Li, Ranjani Lakshminarasimhan, Yi-Tsung Lu
Publikováno v: Int J Cancer
Highly tumorigenic, drug-resistant cancer stem-like cells drive cancer progression. These aggressive cells can arise repeatedly from bulk tumor cells independently of mutational events, suggesting an epigenetic mechanism. To test this possibility, we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fcb2ce0e4b0bd438ce60c6e305799e7
https://pubmed.ncbi.nlm.nih.gov/32017074
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6
Abstract 5282: Transition to and from a cancer stem-like state is marked by rapid metabolic shifts that are observable in real time using fluorescence lifetime imaging microscopy (FLIM)
Autor: Amir Goldkorn, Scott E. Fraser, Tong Xu, Nicholas A. Graham, Peggy J. Farnham, Alireza Delfarah, Kevin Delijani, Cosimo Arnesano, Zhifei Luo, Emmanuelle Hodara
Publikováno v: Cancer Research. 79:5282-5282
Introduction: Highly tumorigenic, drug resistant cancer stem-like cells play a key role in therapy resistance and disease progression. We and others have previously shown that cancer cells can transition cyclically in and out of this aggressive pheno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5774461ff6461ff53fa6e99a7425b6a0
https://doi.org/10.1158/1538-7445.am2019-5282
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8
The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division
Autor: Ely Contreras, Silvia Senese, Julian P. Whitelegge, Yu-Chen Lo, Joseph Capri, Emmanuelle Hodara, Edmundo Vides, Jorge Z. Torres, Ankur A. Gholkar
Publikováno v: Cell Reports, Vol 14, Iss 2, Pp 180-188 (2016)
Cell reports, vol 14, iss 2
SummaryMid1 and Mid2 are ubiquitin ligases that regulate microtubule dynamics and whose mutation is associated with X-linked developmental disorders. We show that astrin, a microtubule-organizing protein, co-purifies with Mid1 and Mid2, has an overla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42f1ed093402c75455e3f6cc1f9b563
https://pubmed.ncbi.nlm.nih.gov/26748699
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9
Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis
Autor: Julian P. Whitelegge, Harish Dharmarajan, Ankur A. Gholkar, Yu-Chen Lo, Ely Contreras, Joseph Capri, William J Deardorff, Jorge Z. Torres, Silvia Senese, Emmanuelle Hodara, Peter K. Jackson
Publikováno v: Cell cycle (Georgetown, Tex.), vol 14, iss 7
Cell Cycle
Short-rib polydactyly syndromes (SRPS) arise from mutations in genes involved in retrograde intraflagellar transport (IFT) and basal body homeostasis, which are critical for cilia assembly and function. Recently, mutations in WDR34 or WDR60 (candidat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4461410127f0c8a131c2c674dd31169
https://escholarship.org/uc/item/5rc1v0gq
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