Characteristics and Immunomodulating Functions of Adipose-Derived and Bone Marrow-Derived Mesenchymal Stem Cells Across Defined Human Leukocyte Antigen Barriers

Autor: Matthias Waldner, Wensheng Zhang, Isaac B. James, Kassandra Allbright, Emmanuelle Havis, Jacqueline M. Bliley, Aurora Almadori, Riccardo Schweizer, Jan A. Plock, Kia M. Washington, Vijay S. Gorantla, Mario G. Solari, Kacey G. Marra, J. Peter Rubin

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

BackgroundVascularized composite allotransplantation opens new possibilities in reconstructive transplantation such as hand or face transplants. Lifelong immunosuppression and its side-effects are the main drawbacks of this procedure. Mesenchymal ste

Externí odkaz: https://doaj.org/article/eb8f1bc5e8494cd6a9a97ab9a01dd468

TMEM8C-mediated fusion is regionalized and regulated by NOTCH signalling during foetal myogenesis

Autor: Joana Esteves de Lima, Cédrine Blavet, Marie-Ange Bonnin, Estelle Hirsinger, Emmanuelle Havis, Frédéric Relaix, Delphine Duprez

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2022, 149 (2), pp.dev199928. ⟨10.1242/dev.199928⟩

The location and regulation of fusion events within skeletal muscles during development remain unknown. Using the fusion marker myomaker (Mymk), named TMEM8C in chicken, as a readout of fusion, we identified a co-segregation of TMEM8C-positive cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aaec674653a62408bd8074d42ba123a
https://hal.sorbonne-universite.fr/hal-03545541

NOTCH inhibition promotes myoblast fusion by releasing HEYL repression on TMEM8C regulatory regions in foetal skeletal muscles

Autor: Marie-Ange Bonnin, Estelle Hirsinger, Cédrine Blavet, Delphine Duprez, Emmanuelle Havis, Joana Esteves de Lima

Differentiation and fusion are two intricate processes involved in skeletal muscle development. The close association of differentiation and fusion makes it difficult to address the process of fusion independently of differentiation. Using the fusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de28af0ab271eb495e86f32de9d647a
https://hal.archives-ouvertes.fr/hal-03002440

EGR1 Transcription Factor is a Multifaceted Regulator of Matrix Production in Tendons and Other Connective Tissues

Autor: Delphine Duprez, Emmanuelle Havis

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21, ⟨10.3390/ijms21051664⟩
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1664 (2020)

Although the transcription factor EGR1 is known as NGF1-A, TIS8, Krox24, zif/268, and ZENK, it still has many fewer names than biological functions. A broad range of signals induce Egr1 gene expression via numerous regulatory elements identified in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae4560a68c132db4932f8e87b16fe92
https://pubmed.ncbi.nlm.nih.gov/32121305

Adipose stem cells enhance excisional wound healing in a porcine model

Autor: Gabriella DiBernardo, Kacey G. Marra, Latha Satish, Aurora Almadori, Debra A. Bourne, Liyong Zhang, Nataliya Kostereva, Isaac B. James, Mayara Mytzi de Aquino Silva, Emmanuelle Havis, J. Peter Rubin, Rachel Ann Guest, Jenny Lei, Kassandra Albright, Sheri Wang

Publikováno v: Journal of Surgical Research. 229:243-253

Background Adipose-derived stem cells (ASCs) are capable of secreting regenerative growth factors and replacing multiple tissue types. Although current literature suggests that ASCs accelerate wound healing and reduce scarring, the dose-response rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4016f7dc0133c63d235eb8882d791ae0
https://doi.org/10.1016/j.jss.2018.03.068