Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Emmanuelle Cousin"'
Autor:
Julien Chapuis, Didier Hannequin, Florence Pasquier, Peter Bentham, Alexis Brice, Isabelle Leber, Thierry Frebourg, Jean-François Deleuze, Emmanuelle Cousin, Uma Thaker, Philippe Amouyel, David Mann, Corinne Lendon, Dominique Campion, Jean-Charles Lambert
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 1, Pp 103-106 (2008)
The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE ɛ4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in thre
Externí odkaz:
https://doaj.org/article/6055dd300d734c18aa0d4ae2dbebbdb7
Autor:
Sandrine Macé, Emmanuelle Cousin, Sylvain Ricard, Emmanuelle Génin, Emmanuel Spanakis, Carole Lafargue-Soubigou, Bérengère Génin, Raphaël Fournel, Sandrine Roche, Gilles Haussy, Florence Massey, Stéphane Soubigou, Georges Bréfort, Patrick Benoit, Alexis Brice, Dominique Campion, Melvyn Hollis, Laurent Pradier, Jésus Benavides, Jean-François Deleuze
Publikováno v:
Neurobiology of Disease, Vol 18, Iss 1, Pp 119-125 (2005)
Recent epidemiological, biological and genetic data indicate a relationship between cholesterol and Alzheimer's disease (AD) including the association of polymorphisms of ABCA1 (a gene that is known to participate in cholesterol and phospholipid tran
Externí odkaz:
https://doaj.org/article/c8e0e03b225243b1b5dda3f8c2d79066
Autor:
Sandrine Mace, Maria Del Zompo, Giovanni Severino, Raffaella Ardau, Dana J.H. Niehaus, Claudine Laurent, Emmanuelle Cousin, I. Murad, Esme Jordaan, Jacques Mallet, Murielle Derock, Liezl Koen, Caterina Chillotti, Nicole Faucon Biguet, Corinne Rocher, Rolando Meloni, Mustafa Mujahed, Richard P. Ebstein, Jean-François Deleuze, Issam Bannoura, Louise Warnich, Colette Dib, Stéphane Soubigou
Publikováno v:
Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, Wiley Periodicals, Inc. 2014, 2 (2), pp.152-159. ⟨10.1002/mgg3.54⟩
Molecular Genetics & Genomic Medicine, Wiley Periodicals, Inc. 2014, 2 (2), pp.152-159. ⟨10.1002/mgg3.54⟩
GPR88, coding for a G protein-coupled orphan receptor that is highly represented in the striatum, is a strong functional candidate gene for neuropsychiatric disorders and is located at 1p22-p21, a chromosomal region that we have previously linked to
Autor:
Sandrine Mace, Dominique Campion, Alexis Brice, Laurent Pradier, Didier Hannequin, Jean-François Deleuze, Colette Dib, Emmanuelle Cousin, Corinne Rocher, Emmanuelle Génin, Gaëlle Muzard
Publikováno v:
Neurobiology of Aging. 32:1443-1451
Alzheimer's disease is a genetically complex disorder, for which new putative susceptibility genes are constantly proposed in the literature. We selected 16 candidate genes involved in biological pathways closely related to the pathology, and for whi
Autor:
Jesus Benavides, Emmanuelle Cousin, Carole Lafargue-Soubigou, Georges Bréfort, Laurent Pradier, Dominique Campion, Stéphane Soubigou, Melvyn Hollis, Sandrine Roche, Emmanuel Spanakis, Bérengère Génin, Emmanuelle Génin, Raphaël Fournel, Gilles Haussy, Sylvain Ricard, Sandrine Mace, Florence Massey, Jean-Francois Deleuze, Patrick Benoit, Alexis Brice
Publikováno v:
Neurobiology of Disease, Vol 18, Iss 1, Pp 119-125 (2005)
Recent epidemiological, biological and genetic data indicate a relationship between cholesterol and Alzheimer's disease (AD) including the association of polymorphisms of ABCA1 (a gene that is known to participate in cholesterol and phospholipid tran
Autor:
Laurent Pradier, Emmanuelle Génin, Jesus Benavides, Emmanuelle Cousin, Dominique Campion, Luc Mercken, Thierry Frebourg, Didier Hannequin, Alexis Brice, Sylvain Ricard, Bruno Dubois, Jean-Francois Deleuze, C. Chansac, Sandrine Mace
Publikováno v:
Neuroscience Letters. 342:5-8
Alzheimer's disease (AD) is a genetically complex neurodegenerative disorder and the leading cause of dementia of the elderly. Recently, Hu et al. suggested that a trinucleotide deletion in intron 13 of the APBB1 gene was a factor protecting against
Autor:
Emmanuelle Génin, Emmanuelle Cousin, M. Del Zompo, Sylvain Ricard, Sandrine Mace, J.F. Deleuze, C. Chansac
Publikováno v:
Human Heredity. 56:151-159
Objective: When numerous single nucleotide polymorphisms (SNPs) have been identified in a candidate gene, a relevant and still unanswered question is to determine how many and which of these SNPs should be optimally tested to detect an association wi
Autor:
Thierry Frebourg, Alexis Brice, Emmanuelle Génin, Emmanuelle Cousin, Christophe Brun, Bruno Dubois, C. Chansac, Sandrine Mace, Dominique Campion, Jean-Francois Deleuze, Didier Hannequin, Laurent Pradier, Sylvain Ricard
Publikováno v:
Neuroscience Letters. 353:153-155
Polymorphisms in the Nicastrin (NCSTN) gene have recently been associated with familial early-onset Alzheimer's disease (AD). The authors genotyped four NCTSN polymorphisms in a large cohort of 489 AD cases (including 158 sporadic early-onset AD case
Autor:
Yves Vaubien, Rolando Meloni, Maria Del Zompo, Mariapaola Piccardi, Stéphane Soubigou, Emmanuelle Génin, Jean-Francois Deleuze, Raffaella Ardau, Colette Dib, Emmanuelle Cousin, Sandrine Roche, Raphaël Fournel, Jacques Mallet, Nicole Faucon Biguet, Gaëlle Muzard, Murielle Derock, Caterina Chillotti, Giovanni Severino, Laurent Bowen-Squires
Publikováno v:
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. (6)
The discovery of the genetic factors implicated in the predisposition to complex diseases may greatly profit from genetic studies in isolated populations. In this perspective, we performed a genome-wide scan using 507 microsatellite markers, with an
Autor:
Detlef Kozian, Jean-François Deleuze, Sandrine Mace, Martin Lorenz, Winfried März, Emmanuelle Cousin
Publikováno v:
Thrombosis and haemostasis. 103(5)
SummaryThe thrombin-activatable fibrinolysis inhibitor (TAFI) is a key mediator in the regulation of endogenous fibrinolysis, down-regulating clot lysis by degrading the C-terminal lysine residues from fibrin, which are important for binding and acti