Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Emmanuele Crespan"'
Autor:
Valentina Pirota, Angela Dello Stritto, Lisa Rita Magnaghi, Raffaela Biesuz, Filippo Doria, Mariella Mella, Mauro Freccero, Emmanuele Crespan
Publikováno v:
ACS Omega, Vol 9, Iss 45, Pp 45203-45213 (2024)
Externí odkaz:
https://doaj.org/article/1a61e304075048f5882e7242703e0d4b
Autor:
Salvatore Princiotto, Loana Musso, Fabrizio Manetti, Valentina Marcellini, Giovanni Maga, Emmanuele Crespan, Cecilia Perini, Nadia Zaffaroni, Giovanni Luca Beretta, Sabrina Dallavalle
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2382-2394 (2022)
Inhibition of c-Src is considered one of the most studied approaches to cancer treatment, with several heterocyclic compounds approved during the last 15 years as chemotherapeutic agents. Starting from the biological evaluation of an in-house collect
Externí odkaz:
https://doaj.org/article/95aeb38bd14c4805af558781c3254a39
Autor:
Claudia Contadini, Claudia Cirotti, Anna Carbone, Mehrdad Norouzi, Annarita Cianciusi, Emmanuele Crespan, Cecilia Perini, Giovanni Maga, Daniela Barilà, Francesca Musumeci, Silvia Schenone
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 958 (2023)
Src is a non-receptor tyrosine kinase (TK) whose involvement in cancer, including glioblastoma (GBM), has been extensively demonstrated. In this context, we started from our in-house library of pyrazolo[3,4-d]pyrimidines that are active as Src and/or
Externí odkaz:
https://doaj.org/article/cb6c5b3f3a3c4429a456fa6d37613bc6
Autor:
Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Claudia Pasqualini, Emmanuele Crespan, Giovanni Maga, Cecilia Perini, Noemi Cabella, Lorenzo Botta, Francesca Musumeci, Maria Frosini, Silvia Schenone, Elena Dreassi
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 453 (2023)
The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies for the treatment of glioblastoma (GBM). Pyrazolo[3,4-d]pyrimidines have already been reported as promising small molecules active as c-Src/Abl dual
Externí odkaz:
https://doaj.org/article/ccd671932b5b41839203be632d83a138
Autor:
Enrico Rango, Salvatore Di Maria, Claudio Zamperini, Federica Poggialini, Emmanuele Crespan, Cecilia Perini, Samantha Sabetta, Simona Saponara, Fabio Fusi, Giovanni Maga, Adriano Angelucci, Eugenio Gaudio, Francesco Berton, Silvia Schenone, Lorenzo Botta, Elena Dreassi, Maurizio Botta
Publikováno v:
Pharmaceutical Chemistry Journal. 56:1616-1626
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::234f0006daf6b3240551930e53465813
https://doi.org/10.1007/s11094-023-02836-x
https://doi.org/10.1007/s11094-023-02836-x
Autor:
Schenone, Claudia Contadini, Claudia Cirotti, Anna Carbone, Mehrdad Norouzi, Annarita Cianciusi, Emmanuele Crespan, Cecilia Perini, Giovanni Maga, Daniela Barilà, Francesca Musumeci, Silvia
Publikováno v:
Pharmaceuticals; Volume 16; Issue 7; Pages: 958
Src is a non-receptor tyrosine kinase (TK) whose involvement in cancer, including glioblastoma (GBM), has been extensively demonstrated. In this context, we started from our in-house library of pyrazolo[3,4-d]pyrimidines that are active as Src and/or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::43d6f80167150a87d487441daa4aef0d
Autor:
Valentina Pirota, Enrico Lunghi, Alessandra Benassi, Emmanuele Crespan, Mauro Freccero, Filippo Doria
Publikováno v:
Molecules, Vol 26, Iss 16, p 5025 (2021)
G-quadruplexes (G4s) are higher-order supramolecular structures, biologically important in the regulation of many key processes. Among all, the recent discoveries relating to RNA-G4s, including their potential involvement as antiviral targets against
Externí odkaz:
https://doaj.org/article/c8a0fe8cd7f548619ee1dc9f9ca1239b
Autor:
Emmanuele Crespan, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon, Giovanni Maga
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides
Externí odkaz:
https://doaj.org/article/763387984e1f4e0ab862ad33d073b020
Autor:
Maria Grazia Martina, Filomena Sannio, Emmanuele Crespan, Marialaura Pavone, Alice Simoncini, Francesca Barbieri, Cecilia Perini, Emanuela Pesce, Giovanni Maga, Nicoletta Pedemonte, Jean‐Denis Docquier, Marco Radi
Publikováno v:
ChemMedChem. 17
Cystic fibrosis (CF) is a genetic disease caused by loss-of-function mutations in the CFTR gene, which codes for a defective ion channel. This causes an electrolyte imbalance and results in a spiral of negative effects on multiple organs, most notabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2165ffa1d1aab82175e98e247e744b5
https://doi.org/10.1002/cmdc.202200277
https://doi.org/10.1002/cmdc.202200277
Autor:
Riccardo, Ronco, Cecilia, Perini, Riccardo, Currò, Natalia, Dominik, Stefano, Facchini, Alice, Gennari, Roberto, Simone, Skye, Stuart, Sara, Nagy, Elisa, Vegezzi, Ilaria, Quartesan, Amar, El-Saddig, Timothy, Lavin, Arianna, Tucci, Agnieszka, Szymura, Luiz Eduardo, Novis De Farias, Alexander, Gary, Megan, Delfeld, Priscilla, Kandikatla, Nifang, Niu, Sanjukta, Tawde, Joseph, Shaw, James, Polke, Mary M, Reilly, Nick W, Wood, Emmanuele, Crespan, Christopher, Gomez, Jin Yun, Helen Chen, Jeremy Dan, Schmahmann, David, Gosal, Henry, Houlden, Soma, Das, Andrea, Cortese
Publikováno v:
Neurology.
Cerebellar Ataxia, Neuropathy and Vestibular Areflexia Syndrome (CANVAS) is an autosomal recessive neurodegenerative disease characterized by adult onset and slowly progressive sensory neuropathy, cerebellar dysfunction, and vestibular impairment. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99c5c9bef884747d0fc17c5c8b62c065
https://pubmed.ncbi.nlm.nih.gov/36289003
https://pubmed.ncbi.nlm.nih.gov/36289003