Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Emmanuel Zazopoulos"'
Autor:
Ming Ma, Hui Jiang, Jeremy R. Lohman, Jeong-Woo Seo, Chris M. Farnet, Chunying Yang, Emmanuel Zazopoulos, John L. Cleveland, Jianhua Ju, Si-Kyu Lim, Thomas Kwong, Ben Shen
Publikováno v:
Biochemistry
Lactimidomycin (LTM, 1) and iso-migrastatin (iso-MGS, 2) belong to the glutarimide-containing polyketide family of natural products. We previously cloned and characterized the mgs biosynthetic gene cluster from Streptomyces platensis NRRL 18993. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e910f034bbc4680c667a8baf6d770f
http://europepmc.org/articles/PMC4270375
http://europepmc.org/articles/PMC4270375
Autor:
Anne Marie Alarco, Dan Sørensen, Arjun H. Banskota, Emmanuel Zazopoulos, Mahmood Piraee, Christophe Mellon, Chris M. Farnet, Henriette Gourdeau, Ashraf S. Ibrahim, Mustapha Aouidate, James B. McAlpine, Pierre Falardeau
Publikováno v:
The Journal of Antibiotics. 62:565-570
The deposited strain of the hazimicin producer, Micromonospora echinospora ssp. challisensis NRRL 12255 has considerable biosynthetic capabilities as revealed by genome scanning. Among these is a locus containing both type I and type II PKS genes. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79a0d9e16cc2bed0225f57ac9043aaf
https://doi.org/10.1038/ja.2009.77
https://doi.org/10.1038/ja.2009.77
Autor:
Jaclyn M. Winter, Michelle C. Moffitt, Pieter C. Dorrestein, James B. McAlpine, Bradley S. Moore, Emmanuel Zazopoulos
Publikováno v:
Journal of Biological Chemistry. 282:16362-16368
Structural inspection of the bacterial meroterpenoid antibiotics belonging to the napyradiomycin family of chlorinated dihydroquinones suggests that the biosynthetic cyclization of their terpenoid subunits is initiated via a chloronium ion. The vanad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d5ea15d96c896c59581965949e160be
https://doi.org/10.1074/jbc.m611046200
https://doi.org/10.1074/jbc.m611046200
Autor:
Mustapha Aouidate, Ashraf S. Ibrahim, Dan Sørensen, Chris M. Farnet, James B. McAlpine, Emmanuel Zazopoulos, Arjun H. Banskota, Anne Marie Alarco, Mahmood Piraee
Publikováno v:
The Journal of Antibiotics. 59:533-542
Genomic analyses of Amycolatopsis orientalis ATCC 43491 strain, deposited as a vancomycin producer, revealed the presence of genetic loci for the production of at least 10 secondary metabolites other than vancomycin. One of these gene clusters, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e185de53d27a0e5d02b17ba01dc81b4f
https://doi.org/10.1038/ja.2006.74
https://doi.org/10.1038/ja.2006.74
Autor:
Alfredo Staffa, Ben Shen, Koichi Nonaka, Wen Liu, Jon S. Thorson, Joachim Ahlert, Kexue Huang, Chris M. Farnet, Emmanuel Zazopoulos, Brian O. Bachmann
Publikováno v:
Nature Biotechnology. 21:187-190
Genome analysis of actinomycetes has revealed the presence of numerous cryptic gene clusters encoding putative natural products. These loci remain dormant until appropriate chemical or physical signals induce their expression. Here we demonstrate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbb4a91ea3d26e2c74f2584faa44ccd5
https://doi.org/10.1038/nbt784
https://doi.org/10.1038/nbt784
Autor:
Enzo Lalli, Emmanuel Zazopoulos, Dino Moras, Tim M. Strom, Paolo Sassone-Corsi, Barbara Bardoni, Jean-Marie Wurtz
Publikováno v:
Molecular Endocrinology. 11:1950-1960
The DAX-1 gene encodes an unusual member of the nuclear hormone receptor superfamily. Mutations in the human DAX-1 gene cause X-linked adrenal hypoplasia congenita associated with hypogonadotropic hypogonadism. We have shown that DAX-1 binds to hairp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb19e0cbb2caff9c36b42224ab95be1
https://doi.org/10.1210/mend.11.13.0038
https://doi.org/10.1210/mend.11.13.0038
Autor:
Paolo Sassone-Corsi, Katherine Tamai, Janet S. Lee, Nicholas S. Foulkes, Lucia Penna, Enzo Lalli, Mónica Lamas, Francois Nantel, Emmanuel Zazopoulos
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 351:201-209
In eukaryotes, transcriptional regulation upon stimulation of the adenylate cyclase signalling pathway is mediated by a family of cAMP-responsive nuclear factors. This family consists of a large number of members which may act as activators or repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9c71979a1ca06070fc469323a972e6
https://doi.org/10.1098/rstb.1996.0017
https://doi.org/10.1098/rstb.1996.0017
Publikováno v:
Virology. 194:20-27
The effect of multiple alleles of nef of the human immunodeficieney virus type 1 (HIV-1) on virus replication was examined. Nef alleles used include some derived from isolates of virus passaged in tissue culture as well as others obtained by direct c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a117ccac8588d839dcc1ce21530a72f9
https://doi.org/10.1006/viro.1993.1230
https://doi.org/10.1006/viro.1993.1230
Autor:
Jianhua Ju, Zhiyang Feng, Chris M. Farnet, Ben Shen, Scott R. Rajski, Hui Jiang, Jeong-Woo Seo, Si-Kyu Lim, Emmanuel Zazopoulos, Yihua Chen
Publikováno v:
The Journal of biological chemistry. 284(43)
iso-Migrastatin and related glutarimide-containing polyketides are potent inhibitors of tumor cell migration and their implied potential as antimetastatic agents for human cancers has garnered significant attention. Genome scanning of Streptomyces pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e593b84ddb2dafbe4f896234789b92f9
https://pubmed.ncbi.nlm.nih.gov/19726666
https://pubmed.ncbi.nlm.nih.gov/19726666
Autor:
Arjun H. Banskota, James B. McAlpine, Jeffrey E. Janso, Mustapha Aouidate, Zhizi Zhao, Romila D. Charan, Xidong Feng, Valerie S. Bernan, Guy T. Carter, Gerhard Schlingmann, Mahmood Piraee, Chris M. Farnet, Emmanuel Zazopoulos
The novel microbial metabolite diazepinomicin/ECO-4601 (1) has a unique tricyclic dibenzodiazepinone core, which was unprecedented among microbial metabolites. Labeled feeding experiments indicated that the carbocyclic ring and the ring nitrogen of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab1691fe1b699e3056677a818e68126
https://doi.org/10.1021/np800376n
https://doi.org/10.1021/np800376n
