Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Emmanuel Y Dotsey"'
Autor:
Johannes S Gach, Andrea Gorlani, Emmanuel Y Dotsey, Juan C Becerra, Chase T M Anderson, Baiba Berzins, Philip L Felgner, Donald N Forthal, Steven G Deeks, Timothy J Wilkin, Joseph P Casazza, Richard A Koup, Christine Katlama, Brigitte Autran, Robert L Murphy, Chad J Achenbach
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160341 (2016)
Little is known about the humoral immune response against DNA prime-recombinant adenovirus 5 (rAd5) boost HIV vaccine among HIV-infected patients on long-term suppressive antiretroviral therapy (ART). Previous studies emphasized cellular immune respo
Externí odkaz:
https://doaj.org/article/05060ed186404214b00da813729017ee
Autor:
Emmanuel Y Dotsey, Andrea Gorlani, Sampat Ingale, Chad J Achenbach, Donald N Forthal, Philip L Felgner, Johannes S Gach
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125581 (2015)
In recent years, high throughput discovery of human recombinant monoclonal antibodies (mAbs) has been applied to greatly advance our understanding of the specificity, and functional activity of antibodies against HIV. Thousands of antibodies have bee
Externí odkaz:
https://doaj.org/article/25114a3849f94a04b1c16365d00d3290
Autor:
Kasper D. Rand, Marco Mor, Caterina Carmi, Michele Bassi, Ingvar R. Möller, Emmanuel Y. Dotsey, Daniele Piomelli, Alessio Lodola, Faizy Ahmed, Don Wei, Nephi Stella, Federica Vacondio, Jennifer Daglian, Simar Singh, Riccardo Castelli, Silvia Rivara, Mattia Anselmi, Kwang-Mook Jung, Stefano Vezzosi, Laura Scalvini, Francesca Ferlenghi
Publikováno v:
Journal of Medicinal Chemistry. 63:1261-1280
We describe a set of benzisothiazolinone (BTZ) derivatives that are potent inhibitors of monoacylglycerol lipase (MGL), the primary degrading enzyme for the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Structure-activity relationship studies ev
Autor:
Shannon Takala-Harrison, Andrea A. Berry, Matthew B. Laurens, Jason A. Bailey, John C. Tan, Mahamadou A. Thera, Andrew Pike, Philip L. Felgner, Jigar Patel, Mark A. Travassos, Ogobara K. Doumbo, Christopher V. Plowe, Matthew Adams, Drissa Coulibaly, Bourema Kouriba, Kirsten E. Lyke, Sheetij Dutta, Amadou Niangaly, Amed Ouattara, Rie Nakajima, Algis Jasinskas, Christopher G Jacob, Jozelyn Pablo, Ryan M. Bannen, Emmanuel Y. Dotsey, Sarah Boudova
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific reports, vol 10, iss 1
Vaccines based on Plasmodium falciparum apical membrane antigen 1 (AMA1) have failed due to extensive polymorphism in AMA1. To assess the strain-specificity of antibody responses to malaria infection and AMA1 vaccination, we designed protein and pept
Autor:
Hollie Y. Wong, Aaron P. Esser-Kahn, Emmanuel Y. Dotsey, Lalisa Stutts, Philip L. Felgner, Janine K. Tom, Troy Moore, D. Huw Davies
Publikováno v:
ACS Central Science
ACS Central Science, Vol 1, Iss 8, Pp 439-448 (2015)
ACS Central Science, Vol 1, Iss 8, Pp 439-448 (2015)
We present the synthesis of novel adjuvants for vaccine development using multivalent scaffolds and bioconjugation chemistry to spatially manipulate Toll-like receptor (TLR) agonists. TLRs are primary receptors for activation of the innate immune sys
Autor:
Irina Ushach, Algis Jasinskas, Donovan A Argueta, Peter D. Crompton, Rie Nakajima, Egest J. Pone, Nicholas V. DiPatrizio, Philip L. Felgner, Huw Davies, Emmanuel Y. Dotsey, Albert Zlotnik, Andrea Dillon
Publikováno v:
Scientific reports, vol 7, iss 1
Scientific Reports
Scientific Reports
The hallmark of vaccines is their ability to prevent the spread of infectious pathogens and thereby serve as invaluable public health tool. Despite their medical relevance, there is a gap in our understanding of the physiological factors that mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d2f49453fb698662df88231c0afb8b
https://escholarship.org/uc/item/2661n71c
https://escholarship.org/uc/item/2661n71c
Autor:
Nur Haq Alam, Stephen B. Calderwood, Jens Wrammert, Mohammad Rubel Hoq, Rie Nakajima, Firdausi Qadri, Rasheduzzaman Rashu, Meagan Kelly, Justin T. O’Neal, Pavol Kováč, Atiqur Rahman, Jason B. Harris, Edward T. Ryan, Siddhartha Kumar Bhaumik, Peng Xu, Algis Jasinskas, Leslie M. Mayo-Smith, Ashraful Islam Khan, Fahima Chowdhury, Taufiqur Rahman Bhuiyan, Emmanuel Y. Dotsey, Levelle D. Harris, Richelle C. Charles, Robert C. Kauffman, Phillip L. Felgner, Jessica F. Trost
Publikováno v:
mBio
mBio, vol 7, iss 6
mBio, Vol 7, Iss 6, p e02021-16 (2016)
mBio, Vol 7, Iss 6 (2016)
mBio, vol 7, iss 6
mBio, Vol 7, Iss 6, p e02021-16 (2016)
mBio, Vol 7, Iss 6 (2016)
We characterized the acute B cell response in adults with cholera by analyzing the repertoire, specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) generated from single-cell-sorted plasmablasts. We found that the cholera-i
Autor:
Chad Greef, D. Huw Davies, Jennipher Grudzien, Aarti Jain, Florian G. Bell, Philip L. Felgner, Abraham P. Lee, Dan Schwartz, Emmanuel Y. Dotsey, Derek Vallejo, Li Liang, Omid Taghavian
Publikováno v:
Jain, Aarti; Taghavian, Omid; Vallejo, Derek; Dotsey, Emmanuel; Schwartz, Dan; Bell, Florian G; et al.(2016). Evaluation of quantum dot immunofluorescence and a digital CMOS imaging system as an alternative to conventional organic fluorescence dyes and laser scanning for quantifying protein microarrays. PROTEOMICS, 16(8), 1271-1279. doi: 10.1002/pmic.201500375. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/6zq1k690
Organic fluorescent dyes are widely used for the visualization of bound antibody in a variety of immunofluorescence assays. However, the detection equipment is often expensive, fragile, and hard to deploy widely. Quantum dots (Qdot) are nanocrystals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3a21cf8fcc9ad2d9b4dc49e5fa1ced
http://www.escholarship.org/uc/item/6zq1k690
http://www.escholarship.org/uc/item/6zq1k690
Autor:
Mary Lopez-Perez, Aarti Jain, Emmanuel Y. Dotsey, D. Huw Davies, Philip L. Felgner, Sócrates Herrera, Kelly Rubiano, Myriam Arévalo-Herrera
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004563 (2016)
PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004563 (2016)
Background Acquisition of malaria immunity in low transmission areas usually occurs after relatively few exposures to the parasite. A recent Plasmodium vivax experimental challenge trial in malaria naïve and semi-immune volunteers from Colombia show
Autor:
Timothy J. Wilkin, Philip L. Felgner, Johannes S. Gach, Chase T. M. Anderson, Steven G. Deeks, Christine Katlama, Donald N. Forthal, Andrea Gorlani, Chad J. Achenbach, Brigitte Autran, Richard A. Koup, Emmanuel Y. Dotsey, Joseph P. Casazza, Baiba Berzins, Juan C. Becerra, Robert L. Murphy
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160341 (2016)
PLoS ONE
PloS one, vol 11, iss 8
PLoS ONE
PloS one, vol 11, iss 8
Little is known about the humoral immune response against DNA prime-recombinant adenovirus 5 (rAd5) boost HIV vaccine among HIV-infected patients on long-term suppressive antiretroviral therapy (ART). Previous studies emphasized cellular immune respo