Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Emmanuel Twumasi Osei"'
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract IPF is a fatal lung disease characterized by intensive remodeling of lung tissue leading to respiratory failure. The remodeling in IPF lungs is largely characterized by uncontrolled fibrosis. Fibroblasts and their contractile phenotype the m
Externí odkaz:
https://doaj.org/article/123a0de2908b475bb6ca6238b059800a
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract The pulmonary extracellular matrix (ECM) is a macromolecular structure that provides mechanical support, stability and elastic recoil for different pulmonary cells including the lung fibroblasts. The ECM plays an important role in lung devel
Externí odkaz:
https://doaj.org/article/b7a06b71ce6d4cef86792a987faef788
Autor:
Aileen Hsieh, Chen Xi Yang, May Al-Fouadi, Kingsley Okechukwu Nwozor, Emmanuel Twumasi Osei, Tillie-Louise Hackett
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
RationaleIn the healthy lung, the pseudostratified conducting airway epithelium is anchored to the reticular basement membrane (RBM) via hemidesmosome junction complexes formed between basal cells and the extracellular matrix (ECM). The RBM within th
Externí odkaz:
https://doaj.org/article/336e65a22e774fd9bb48ea9cf5017559
Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma
Autor:
Anthony Tam, Emmanuel Twumasi Osei, Chung Y. Cheung, Michael Hughes, Chen X. Yang, Kelly M. McNagny, Delbert R. Dorscheid, Gurpreet K. Singhera, Teal S. Hallstrand, Stephanie Warner, James C. Hogg, Tillie L. Hackett, Chinten J. Lim, Don D. Sin
Publikováno v:
Cells, Vol 11, Iss 19, p 3016 (2022)
Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (PTCH1) are associated with lung function abnormalities in the general population. It has also been shown that sonic hedgehog (SHH), an important ligand for PTCH1, i
Externí odkaz:
https://doaj.org/article/dd1914f393004b81bde0752df491967b
Publikováno v:
Cells, Vol 10, Iss 8, p 2145 (2021)
The lung extracellular matrix (ECM) is a complex and dynamic mixture of fibrous proteins (collagen, elastin), glycoproteins (fibronectin, laminin), glycosaminoglycans (heparin, hyaluronic acid) and proteoglycans (perlecan, versican), that are essenti
Externí odkaz:
https://doaj.org/article/33551f3df918435e8920411a4a329f3c
Publikováno v:
Cells, Vol 9, Iss 7, p 1694 (2020)
As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU).
Externí odkaz:
https://doaj.org/article/89bbcc05b6a641798e17529b0f923ca2