Editorial: Next generation in vitro models to study chronic pulmonary diseases

Autor: Fama Thiam, Alen Faiz, Simon D. Pouwels, Emmanuel T. Osei

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

Externí odkaz: https://doaj.org/article/983cac8adf2e4730bb699b225ae7e952

The Role of the Dynamic Lung Extracellular Matrix Environment on Fibroblast Morphology and Inflammation

Autor: Tillie-Louise Hackett, Noamie R. T. F. Vriesde, May AL-Fouadi, Leila Mostaco-Guidolin, Delaram Maftoun, Aileen Hsieh, Nicole Coxson, Kauna Usman, Don D. Sin, Steve Booth, Emmanuel T. Osei

Publikováno v: Cells, Vol 11, Iss 2, p 185 (2022)

The extracellular matrix (ECM) supports lung tissue architecture and physiology by providing mechanical stability and elastic recoil. Over the last several decades, it has become increasingly clear that the stiffness of the ECM governs many cellular

Externí odkaz: https://doaj.org/article/1ef2390667924e9cb87f3f36385cfc26

Second harmonic generation imaging of collagen scaffolds within the alveolar ducts of healthy and emphysematous mouse lungs

Autor: Aileen Hsieh, May Fouadi, Dragoș șM Vasilescu, Emmanuel T. Osei, Alan L. Scott, Leila B. Mostaço-Guidolin, Jeffrey Loube, Christine Young, Wayne Mitzner, Tillie L. Hackett, Aaron M. Barlow

Publikováno v: Histochemistry and Cell Biology. 155:279-289

The alveolar ducts are connected to peripheral septal fibers which extend from the visceral pleura into interlobular septa, and are anchored to axial fibers in the small airways. Together these axial and septal fibers constitute a fiber continuum tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bad60c945f7334b7860df2f85f33e00
https://doi.org/10.1007/s00418-020-01959-6

Defective Fibrillar Collagen Organization by Fibroblasts Contributes to Airway Remodeling in Asthma

Autor: Emmanuel T. Osei, Irene H. Heijink, Xian Li, Darren J. Cole, Corry-Anke Brandsma, Chen Xi Yang, Tillie-Louise Hackett, Leila B. Mostaço-Guidolin, Vicky Li, May Fouadi, Soheil M. Hajimohammadi, Geoffrey N. Maksym, David C. Walker, Fanny Chu, Furquan Shaheen, Jari Ullah

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 200(4), 431-443. AMER THORACIC SOC

RATIONALE: Histological stains have been used as the gold standard to visualize extracellular matrix (ECM) changes associated with airway remodeling in asthma, yet they provide no information on the biochemical and structural characteristics of the E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b247549d72b9270aff385eb29f8117
https://doi.org/10.1164/rccm.201810-1855oc

Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts

Autor: Mary Wang, Darren J. Cole, Teal S Hallstrand, Tillie-Louise Hackett, Leila B. Mostaço-Guidolin, Emmanuel T. Osei, Wim Timens, Aileen Hsieh, Stephanie M. Warner, May Al-Fouadi, Geoffrey N. Maksym, Corry-Anke Brandsma, Irene H. Heijink

Publikováno v: Scientific Reports, 10(1):8721. Nature Publishing Group
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

In asthma, the airway epithelium has an impaired capacity to differentiate and plays a key role in the development of airway inflammation and remodeling through mediator release. The study objective was to investigate the release of (IL)-1 family mem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7959401153c2d1137fbcf2d740577115
https://hdl.handle.net/11370/cf3098c9-9aa4-491e-9584-84efa035f37a