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pro vyhledávání: '"Emmanuel Sabalan"'
Autor:
Jason Duquette, Emmanuel Sabalan, Ji Ma, Xiaoqi Chen, Shichang Miao, Julio C. Medina, Darin J. Gustin, Zhulun Wang, Lawrence R. McGee, Kirk Henne, Tassie L. Collins, George Tonn, Karen Ebsworth, Tim Sullivan, Xiaohui Du, Bryan Lemon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5200-5204
A general way of improving the potency of CXCR3 antagonists with fused hetero-bicyclic cores was identified. Optimization efforts led to the discovery of a series of imidazo-pyrazine derivatives with improved pharmacokinetic properties in addition to